Peds Quizlet Flashcards
Anatomical changes: head
larger occiput
Anatomical changes: respiration pattern
obligate nose breathers
Anatomical changes: Larynx. What vertebrae is it located at?
more cephalad - C3-C4
Anatomical changes: epiglottis
omega shaped and longer
Anatomical changes: vocal cords
slant caudally at arytenoid insertion
Anatomical changes: trachea
shorter, 4-5 cm
What is the (functionally) narrowest part of the pediatric airway?
Cricoid ring
Anatomical changes: right mainstem bronchus
acute angle at the carina
Pediatric patients have turbulent gas flow until the ______th (#) bronchial division
5
Resistance is inversely related to _________ to the _______ power
radius; 5th
A 50% reduction in the radius of the cricoid ring ___________(increases/decreases) pressure drop by ______ times, which increases work of breathing
decreases, 32
What is the ratio of alveolar ventilation: FRC in children compared to adults? Why?
5:1 vs. 1.5:1; because of their increased O2 consumption per kg
Anatomical changes: rib cage
increased compliance
anatomical changes: lung compliance. Why?
decreased - lack of elastin
anatomical changes: fibers in the diaphragm - what is the significance of this?
There are reduced type 1 fibers which are the “marathon runner fibers” - aka the longer acting fibers. Makes patient more likely to have fatigued muscles leading to respiratory failure
What is the most common problem leading to upper airway obstruction in pediatrics and how is it treated?
Laryngomalacia; positive pressure, usually resolves with age
Name that condition: Supraglottic structures converge on the glottic opening, leading to retractions, paradoxical chest movement, and exaggerated diaphragm excursion
Laryngomalacia
Name that condition: Micrognathia, airway distress, glossoptosis
Pierre Robin
Name that condition: airway becomes MORE difficult with age
Treacher collins
True or false: down syndrome patients, and those with Crouson and Apert disease are often difficult intubations?
False - they are difficult to mask but easy intubation
What is the airway finding associated with both down syndrome and beckwith syndrome?
large tongue
What is the airway finding associated with “please get that chin” (pierre robin, goldenhar, treacher collings, cri du chat)
Small mandible
What is the airway finding associated with the acronym “kids try gold” (Klippel-feli, trisomy 21, goldenhar)
cervical spine anomaly
True or false: trisomy 21 patients often have large tongues and cervical spine anomalies
T
True or false: goldenhar patients often have small jaws and cervical spine anomalies
T
Name that condition: small smouth, small mandible, choanal atresia, eye and ear anomalies
Treacher Collins
Name that condition: small mouth, large tongue, atlantoaxial instability, small subglottic diameter
Trisomy 21
Name that condition: small mandible/ micrognathia, tonge that falls back and downwards (glossoptosis)
pierre robin
Name that condition: small mandible, laryngomalacia, stridor
Cri du chat
Increase/ Decrease in Peds: atelectasis risk
increase
Increase/ Decrease in Peds: O2 reserve and FRC
decrease
Increase/ Decrease in Peds: PNS activity
relative increase
Increase/ Decrease in Peds: SV compensation/ SVR tone
decrease
Increase/ Decrease in Peds: CBF? What is normal?
increase - normal is 70-110ml/100g of brain/min
Increase/ Decrease in Peds: CMRO2? What is normal?
increase - 5.5ml/100g/min
Increase/ Decrease in Peds: Autoregulation
no change
Increase/ Decrease in Peds: pH of gastric juice
increase (less acidic)
Increase/ Decrease in Peds: Albumin and Alpha-1 Glycoprotein. Which one binds to basic drugs?
decrease - Alpha 1 binds to basic
Increase/ Decrease in Peds: GFR
decrease
Why is CO so heart rate dependent in pediatric patients?
There is reduced ability to compensate by increases stroke volume
Atropine increases CO in peds patients in 2 ways, what are they?
- increasing HR
- augmenting calcium force
Normal HR and BP: 0-3 months
HP: 100-150
BP: 60-85/ 45-55
Normal HR and BP: 3-6 months
HR: 90-120
BP: 70-90/ 50-65
Normal HR and BP: 6-12 months
HR: 80-120
BP: 80-100/ 55-65
Normal HR and BP: 1-3 years
HR: 70-110
BP: 90-105/ 55-70
Normal HR and BP: 3-6 years
HR: 65-110
BP: 95-110/60-75
Normal HR and BP: 6-12 years
HR: 60-95
BP: 100-120/60-75
Normal HR and BP: >12 years
HR: 55-85
BP: 110-135/ 65-85
Increase or decrease in peds: O2 consumption - what is normal?
increase - 5.5ml/100g/min
CBF in children is directed largely towards ________ matter
gray
Drugs that act on NMDA/GABA receptors cause _______ in children. What can help reduce these effects?
Apoptosis (programmed cell death)
Helps: melatonin, lithium, hypothermia, exercise
True or false: rectal drugs can undergo first-pass metabolism
True- if they are absorbed via rectal superior veins which drain into the portal venous system
The free fraction of lidocaine will be greater in __________ (younger/older) children. Why?
Younger - decreased Alpha 1 Glycoprotein which binds to basic drugs - increases with age
Phase 1 or Phase 2:
-Hydroxylation
-Oxidation
-Glucoronidation
Hydrox.: 1
Ox: 1
Gluco: 2
True or false: The liver does not metabolize drugs well at birth because it is lacking the CYP enzymes needed to do so?
False - enzymes are present but not mature enough (they have not been induced)
Which enzyme metabolizes 50% of drugs?
CYP450 3A4
4 reasons why inhalation induction is faster in pediatric patients?
- increased alveolar ventilation: FRC ratio
- Greater distribution of CO to vessel rich group
- Reduced tissue solubility
- Reduced blood solubility
Does this effect the wash-IN (lung delivery) or wash-OUT (anesthetic removal) of inhaled agents: Inspired concentation
wash-in
Does this effect the wash-IN (lung delivery) or wash-OUT (anesthetic removal) of inhaled agents: alveolar ventilation to FRC ratio
wash-in
Does this effect the wash-IN (lung delivery) or wash-OUT (anesthetic removal) of inhaled agents: Blood gas solubility
wash out
Does this effect the wash-IN (lung delivery) or wash-OUT (anesthetic removal) of inhaled agents: cardiac output
wash out
Does this effect the wash-IN (lung delivery) or wash-OUT (anesthetic removal) of inhaled agents: alveolar-venous partial pressure gradient
wash out
What is the inhaled agent of choice in pediatrics and why?
sevoflurane - less airway irritation
Changes in alveolar ventilation and cardiac output affect the wash-in of __________(less/more) soluble anesthetics to a greater extent?
more
(Nagelhout highway example - the slow cars are going to feel the speed-up more than the fast cars)
Wash-in of ______ solubility anesthetics (high/low) are similar between peds and adults?
low
Order these from least soluble to most soluble: Sevo, Iso, Halothane, Des
- Des
- Sevo
- Iso
- halothane
Spontaneous ventilation works to speed up inhaled induction via _______ feedback (negative/positive), whereas controlled ventilation works to speed up inhaled induction via __________ feedback (negative/positive).
Negative; positive
Explain the “negative feedback” of inhaled induction with spontaneous ventilation
Inhaled anesthetic washes in, and depth of anesthesia increases
As patient gets deeper, breathing is reduced, and therefore uptake of agent is reduced
As agent is redistributed from brain and depth of anesthesia decreases, then ventilation increases again, and uptake is resumed
Explain the “positive feedback” of inhaled induction with controlled ventilation?
Delivery of inhaled agent to the lungs continues which deepens anesthesia
Deeper anesthesia decreases cardiac output
Decreased cardiac output further increases speed of IA induction
A cardiac shunt in which direction greatly impacts wash-in of low solubility inhalation agents? how?
Right to left
Because blood is bypassing the lungs, therefore not interacting with the inhaled agent in the alveoli
At what age does MAC peak?
1-6 months
Is the effect of N2O on the patient’s MAC (when on sevo and des) increased or decreased in pediatric patients as compared to adults?
decreased - 60% O2 only contributes 25% to the MAC value
One degree drop in a child’s temperature will decrease his/her MAC by _______%
5
What does sevoflurane do to cardiac index?
Decreases is by 10% at 1 MAC, 20-30% at 2 MAC
What does IA’s do to tidal volume and respiratory rate? What about minute ventilation?
Decreased tidal volume
Increase RR
Decrease MV
What do IAs do to the response to CO2 and hypoxia?
Decrease it
Airway resistance __________(increases/decreases) with Des, and ___________ (increases/decreases) with Sevo.
Increases; decreaeses
What do do IAs do to QT interval?
Prolong it (>500 msec)
Patients with low values of what 4 labs are at increased risk for torsades?
- mag
- potassium
- calcium
- thyroid hormone (T3/T4)
True or false: Tachycardia puts the patient at increased risk for torsades with prolonged QT from IAs?
False; bradycardia
True or false: Male gender puts the patient at increased risk for torsades with prolonged QT from IAs?
False; female
Which IA uncouples CBF/CMRO2 the LEAST in children?
Sevo (followed by Iso, then Des)
BIS is not precise under the age of ______
5yr
True or false: Sevoflurane at 1 MAC impairs autoregulation in children
false - only > 1.5 MAC
How can the anesthetist help repair autoregulation that has been impaired by high concentrations of Iso or Sevo
hyperventilation
Vd and clearance of propofol _________(increase/decrease) during early childhood
decrease
True or false: propofol should be avoided in children with an egg allergy (per Barash)
True- kinda- only in egg ANAPHYLAXIS
What is an effective blood concentration of Ketamine for anesthesia?
3 mcg/mL
IV, IM, and PO doses of ketamine
IV: 1-2 mg/kg
IM: 2-5 mg/kg
PO: 5-6 mg/kg
How long does it take IM ketamine to onset? When does it peak?
Onset 3-5 min, peak 30-40
Appropriate dose of Etomidate in children?
0.3 mg/kg
What is the neonatal infant dose of succinycholine and why? What about children?
Neonate: 3-4 mg/kg due to larger Vd
Children: 2 mg/kg
What is the most common pediatric side effect of succinylcholine? Why? How can you prevent it?
bradycardia - ACh activation of vagal nerves
Pre-treat with 10/20 mcg/kg of atropine or 5-10 mcg/kg of glyco
How can you treat Hyperkalemia caused by succinylcholine and how does this work?
10mg/kg CaCl - raises threshold potential to prevent arrhythmias
How much does IOP increase with succinylcholine and when does it peak?
7-10 mm Hg, peaks in 1-2 min
What kind of children are at risk for muscle pain after succ and how can you prevent this?
Muscular adolescents - pre-treat with NDMB
What is the earliest sign of MH
increase in ETCO2 accompanied by and increase in RR and low SpO2
Dantrolene dose
2.5 mg/kg
repeated q5-10 min
True or false: Roc is exclusively eliminated by the liver
T
Potency of rocuronium is greatest in what age group and the least in what age group?
Greatest in infants, least in children?
What commonly used anesthetic agent potentiates the effect of rocuronium?
sevo
Rocuronium dose in infants vs. children
Infants: 0.25mg/kg
Children: 0.4-0.6 mg/kg
Increase or decrease in peds: dose of Neostigmine
decrease - dose is 30-40% of adult dose
20-40 mcg/kg up to 70 mcg/kg
Neostigmine dose of > _______ mcg/kg may cause ACh associated weakness
100
Fentanyl is ______ soluble (lipid/water), and primarily bound to ________(albumin/ AAG)
lipid, AAG
What is an IV dose of fentanyl appropriate for pediatric patients?
Minor: 1-3 mcg/kg
Major: 12-50 mcg/kg
What is an appropriate pediatric dose of Meperidine for shivering?
0.5-1 mg/kg
Black box warning for codeine is for what?
Respiratory depression
Ibuprofen vs. Acetaminophen dosing
Acetaminophen: 10-15 mg/kg PO; 20-40 mg/kg PR
Ibuprofen: 10-15mg/kg PO
Midazolam is ______ soluble (water/lipid)
water
IV vs. Nasal versed dosing
IV: 0.1-0.2 mg/kg
Nasal: 0.2-0.3 mg/kg
True or false: Precedex has hemodynamic manifestations via direct AND indirect action on the SNS
T