Peds Onc Flashcards
1
Q
Acute lymphoblastic leukemia- Eti
A
- Most common childhood CA
- 4 = peak age
- Down syndrome increased risk
2
Q
Acute lymphoblastic leukemia- Sx
A
- Anemia
- Decreased platelets (petechiae, purpura)
- Bone pain (Limp, decreased walking, irritability)
- Neutropenia (fever & infection)
- Lymphadenopathy
- Hepatosplenomegaly
- Gingival hypertrophy
3
Q
Acute lymphoblastic leukemia- Dx
A
- BMB
- CBC- Increased WBC, + blasts in smear
- > 2 cytopenias
4
Q
Acute lymphoblastic leukemia- Tx
A
- Chemo- Prednisone/ dexamethasome
5
Q
Brain tumors- Eti
A
- 2nd most common type in children
- Astrocytoma most common
- Type depends on cell of origin
- 50% in posterior fossa
- 50% supratentorial
6
Q
Brain tumors- Sx
A
- > 8y/o
- Developmental delay, loss of milestones
- Endocrinopathy
- AM headache, AM vomiting, papilledema
- 6th nerve palsy
7
Q
Brain tumors- Eti
A
- 2nd most common type in children
- Type depends on cell of origin
- 50% in posterior fossa
- 50% supratentorial
8
Q
Brain tumors- Supratentorial- Sx
A
- > 8y/o
- Developmental delay, loss of milestones
- Endocrineopathy
9
Q
Hodgkin- Sx
A
- Painless lymphadenopathy
- Supraclavicular node
- Mediastinal mass
- Fever, night sweats & wt loss
- Superior mediastinal syndrome- orthopnea, SOB, stridor
- SVC- facial swelling, cyanosis
10
Q
Acute lymphoblastic leukemia-Prog
A
70% cured, cure rate increases with age
- Relapse in CNS or testes
11
Q
Acute myelogenous leukemia- Eti
A
Bone marrow malignancies, more common in adults
- Congenital risk factors
12
Q
Acute myelogenous leukemia- Sx
A
- Anemia
- Thrombocytopenia
- Hypoxia, hemorrhage, infarction, DIC
13
Q
Acute myelogenous leukemia- Dx
A
- BMB- Auer rods
14
Q
Acute myelogenous leukemia- Tx
A
- Chemo
- Stem cell transplant
15
Q
Acute myelogenous leukemia- Prog
A
- Up to 85% remission with aggressive tx
- 50-70% 5 yr survival
