Peds Immuno Flashcards
1
Q
Chronic uritcaria-angioedema (CU)
A
characterized by raised, erythematous, markedly pruritic evanescent lesions and angioedema
- episodes last > 6 weeks
- H1 antagonists are corner stone of therapy - second generation preferred (cetirizine, levocetirizine, fexofenadine, loratadine, desloratadine)
- steroids can be used to attain temporary control of severe symptoms
2
Q
MCC of viral-induced wheezing in infants/children
A
- RSV
- previous infection w/ RSV does not confer complete protection
- infants who have been hospitalized with RSV LRTI have increased risk of wheezing episodes after hospitalization
- RSV infections viewed as potential contributor to dev of asthma
- 50% of pts respond to albuterol vs epinephrine if they have signs of lower respiratory airway obstruction
3
Q
which medication(s) should you d/c prior to allergic skin testing?
A
Antihistamines - d/c for atleast 7 days prior to testing
- first gen have a greater suppressive effect than second
- if a negative or weak response to histamin control obtained on patient who recently took anti-histamines, longer medication free period and repeat testing is recommended
- other meds to d/c:
- H2 receptor blockers (ranitidine, cimetidine) x 48 hours
- TCAs and phenothiazines x 2 weeks
- muscle relaxants and anti-emetic drugs
4
Q
Warning signs of humoral (B cell) immunodeficiency
A
- 4 or more new ear or sinus infections within 1 year
- 2 or more serious sinus infections within 1 year
- 2 or more months of antibiotics with no effect
- 2 or more episodes of pneumonia within 1 year
- failure to gain weight and grow normally
- need for intravenous antibiotics to clear infection
- a family history of primary immune diseases
5
Q
Patient who has recurrent sinusitis and otitis media with effusions, what are the steps in work-up
A
- allergy skin testing
- if allergic evaluation negative –> serum immunoglobulin levels and antibody titers to vaccine antigens
6
Q
Primary Ciliary Dyskinesia
A
- congenital impairment of mucociliary clearance
- CF: chronic cough, chronic rhinitis, chronic sinusitis, visual polyps
- Dx. ciliary biospy
7
Q
A
