Peds 2 Flashcards
Esophageal Atresia
Blind esophageal pouch w/ out w/out fistulous connection between proximal or distal esophagus and trachea
Autism spectrum disorder
Includes autism, Asperger syndrome, pervasive developmental disorder
Lack of interest in others, delayed language, resistant to change, behavior disturbances
Red flags of Autism spectrum disorder
Parental concerns of: deficits in social/language/behavior skills, frequent tantrums, intolerance to change
Not meeting milestones (not babbling/knowing words etc)
Loss of language or social skills at any age
Social Attention vs Joint Attention
Social: absent/limited interest, no eye contact/spacial awareness
Joint: don’t show/bring things to parents, can play alone
Universal screening for ASD
18 and 24 months, or earlier if needed: MCHAT-R/F testing (identifies at risk, not a diagnosis, NO’s are significant) score over 8 refer
ASD Treatment
Early intervention; meds for targeted symptoms (anxiety, oct, etc), vitamins, diets, hyperbaric oxygen
Behavioral and educational interventions
Asperger Syndrome
Symptoms not including significant language or intellectual impairment “high functioning” autism
Treat with symptom reduction
ADD/ADHD categories (2)
Hyperactive/impulsive: apparent by 4, peak by 7-8, hyperactive wanes after 8 but impulsivity persists
Inattention: apparent around 8-9, persists into adulthood
ADHD Hyperactivity Symptoms
Fidgety, “perpetual motion”, excessive talking, interruption, acts without considering consequences, difficulty staying seated
ADHD Inattention Symptoms
Reduced ability to focus, decreased speed of cognitive processing (daydream, “off task”)
Common in premies
Seems to not listen, difficulty organizing, loses thing, forgetful, easily distracted
ADHD Diagnosis (DSM5)
At least 6 symptoms for 6 months that must impair function academically, socially or occupationally
Symptoms present before 12 years and don’t occur during psychosis
No exclusion criteria for pts with ASD
ADHD Assessment Tools
Conners comprehensive behavior rating
ADHD rating scale
Vanderbilt assessment scales (only >4 years)
ADHD Management (not medications)
Eating and sleeping patterns, cardiac exam (BP, HR, auscultation, Marfan check) BEFORE meds
<6: behavioral therapy +/- meds
>6: meds +/- behavioral therapy
ADHD Medications
First line: stimulants
Second line: atomoxetine (strattera), alpha-2-adrenergic agonists
Oppositional Defiant Disorder Categories (3)
1-angry/irritable mood
2- argumentative/defiant behavior
3-vindictiveness
Oppositional Defiant Disorder Diagnosis
At least 4 symptoms from any category occurs for at least 6 months, exhibited during interaction with at least one person thats NOT a sibling
Interferes with social or academic functioning, doesn’t occur during psychotic episode
Oppositional Defiant Disorder Symptoms
Loses temper often, argues with adults, actively defies, deliberately annoys, blames other for mistakes/behavior, angry, resentful, spiteful, vindictive
Oppositional Defiant Disorder Management
Refer to psych for psychometric testing
CBT, psychotherapy, family therapy, anger management, etc
Conduct Disorder Categories (4)
Aggressive (harm others)
Property loss/damage
Deceitful or theft
Violation of rule/laws
Conduct disorder Diagnosis
At least 3 occur in last year with one in last 6 months
Changes to antisocial anxiety disorder if >18
Conduct Disorder Management
Refer to psych
Psychotherapy, CBT, fam therapy, anger management
treat other disorders
Esophageal Atresia Presentation
Only symptomatic within hours of birth (excess saliva, choking, cyanosis and respiratory distress)
Presents slower with tracheoesophageal fistulas
Esophageal Atresia Diagnostics
Prenatal US>MRI
Post-natal: NG tube and chest xray-tube in blind pouch, if gas is present theres a TE fistula distal o esophagus
Esophageal Atresia Treatment
NG tube in proximal pouch w/ low suction
Elevate head of bed
IV glucose, fluids, O2
Surgery
Coin Ingestion Diagnostics/Treatment
see round coin if in esophagus, just edge if in trachea
Retrieve if button battery (emergency), multiple magnets, or if it doesn’t move to stomach
GER
if no secondary symptoms just GER, resolves spontaneously; supportive care, avoid overfeeding
GERD
If failure to thrive, pneumonia, GI bleed, etc is GERD, usually resolves by 12 months, can thicken food with cereal or milk free for 2 weeks
PPIs but can increase infection risk
Nissen fundoplication
Eosinophilic Esophagitis Symptoms and complications
Feeding dysfunction similar to Gerd, long meal times, avoidance of textured food, no response to Gerd treatment
Causes esophageal food impactions and strictures
Eosinophilic Esophagitis Diagnosis
EGD: esophagus sprinkled w/ pinpoint white exudates (eosinophils) like candida
thickening, mucosal fissures, strictures and rings
Eosinophilic Esophagitis Treatment
Elimination of food allergens
Steroids (2 puffs of fluticasone BID 30 mins before food, without rinsing after)
Pica
Eating feces, clay, dirt, hair, ice, etc for at least 1 month
Zinc and iron deficiencies, ^lead
Treat with behavioral therapy and address deficiencies/possible lead poisoning
Rumination
Repeated regurg and rechewing of food for at least 1 month, MC in young kids
Causes cavities, malnutrition, weight loss, failure to thrive
Malabsorption associated with cystic fibrosis
Carbs (lactase deficiency), fat and protein (milk protein allergy)
Presentation of malabsorption
weight loss, malnutrition, diarrhea/steatorrhea, N/V, abdominal pain
Diagnostics of malbsorption
stool sample, dietary testing (removals), celiac and cystic fibrosis workups
Phenylketonuria (PKU)
most common inborn error of amino acid metabolism, decreased activity of phenylalanine hydroxylase
PKU Presentation
Intellectual disability (MC), fair hair and skin, atopic dermatitis, hyperactive, seizures, musty/mousy body and urine odor, epilepsy
PKU Diagnosis and Treatment
Newborn screening
Dietary restriction of phenylalanine (<6mg/dL/day) and aspartame
(restrict starches, proteins; supplements aminos, vitamins and minerals)
Common food allergies
Cow milk, fruit (citrus, strawberry), veggies (tomato), egg, fish, nuts, cereals
Presentation of food allergies
urticaria and angioedema MC
Rhinitis, swelling, asthma, anaphylaxis, N/V, abdominal pain, cramping, diarrhea
Food allergy diagnosis and treatment
IgE testing
epinephrine and H1 blockers
Celiac Disease
malabsorption of gluten causing abd pain, diarrhea, vomiting, bloating, constipattion
associated w/ diabetes, thyroiditis, downs, turner syndrome
Non-GI Celiac disease manifestations
delayed puberty, short stature, iron deficiency anemia
Celiac disease diagnosis/treatment
serology, duodenal biopsy (villous atrophy)
Gluten restriction improves intestinal mucosa within 6-12 months
Gastroschisis and Omphalocele
Abdominal wall defect causing GERD, volvulus, malabsorption
Discovered prenatally on US and elevated alpha-veto protein
Delivered c-section with surgical correction
Omphalacele
Membrane covered herniation of abdominal contents into base of umbilical cord
Gastroschisis
Uncovered intestine through small abdominal wall defect to right of umbilical cord
Increasing incidence bc of meth, coke, young mothers and ibuprofen use
Diaphragmatic Hernia
usually left sided, diagnosed on prenatal ultrasound around 8-10weeks
Can be associated with chromosomal abnormalities and dysmorphisms (craniofacial and extremity)
Diaphragmatic hernia presentation
Respiratory distress in first minutes-hours of life, may require aggressive resuscitation; scaphoid abdomen, barrel-shaped chest, bowel loops in chest with mediastinal shift on xray
signs of pneumothorax with decreased breath sounds
Diaphragmatic hernia treatment/complications
mechanical ventilation and decompression of GI tract with OG tube or surgical reduction
Can cause pulmonary hypertension, GERD, behavior problems
Indirect inguinal hernia
Most common in kids, more common than direct
passes lateral to epigastric vessels through inguinal canal (into testicle)
M>F, mostly right sided
Direct inguinal hernia
Passes medial and inferior to epigastric vessels, goes through Hesselbach triangle (not inguinal canal)
More common in older men
Hesselbach Triangle Borders
Fascia surrounded by: rectus abdominis muscle, inferior epigastric artery and inguinal ligament
Femoral inguinal hernia
follows tract below inguinal ligament through femora canal, medial femoral vein lateral to lacunar ligament
Often incarcerated or strangulated
F>M
Umbilical Hernias
More common in full term black babies, regress spontaneously; repaired if still there at 4 years old
Pyloric Stenosis*
Postnatal muscular hypertrophy of pylorus causing progressive gastric outlet obstruction
M>F, common in first born kids, whites
Pyloric Stenosis Symptoms
Projectile postprandial vomiting, Olive mass in RUQ is hallmark* (esp after vomiting)
upper abdominal distention, visible gastric peristaltic waves
Usually starts at 3-6 weeks
Pyloric stenosis diagnosis
Pyloric ultrasound: hypo echoic muscle ring >4mm thick w/ hyper dense center and >15mm pyloric channel length
Barium swallow: String sign in long pyloric channel
Pyloric stenosis treatment
Surgical repair (pyloromyotomy), high risk of chronic abdominal pain in childhood
Duodenal Atresia
Associated with trisomy 21
Blind pouch or stenosis
“double-bubble sign” on abdominal xray (dilated stomach and proximal duodenum)
Bilious (green) vomiting hours after birth
Surgically corrected
Short bowel syndrome
reduced intestinal absorptive surface typically after resection of intestine
Leads to alternation in intestinal function
Symptoms of short bowel syndrome
Diarrhea, dehydration, electrolyte/micronutrient deficiency, excessive gas, foul smelling stool
Treatment of short bowel status
Diet, TPN (total parenteral nutrition), enteral nutrition (g-tube), antacids, PPIs, antibiotics, surgery
last resort-intestine transplant
Intussusception
Most common bowel obstruction in first 2 years of life, most commonly proximal to ileocecal valve
M>F
Causes of intussusception
85% idiopathic
viral (rotavirus), carcinoma (lymphoma MC >6), henoch-schonlein purpura
Symptoms of intussusception
Red currant jelly stools* (pathognomonic), healthy baby develops recurrent severe, crampy belly pain, vomiting, diarrhea
Palpable right-sided sausage shaped mass
Intussusception diagnostics
Barium + air enema-diagnostic and therapeutic
Ultrasound most sensitive/specific
Xray: target sign
Intussusception Treatment
Air enema is best if stable
Non-operative (contrast enema, hydrostatic or pneumatic pressure)
Successful reduction likelihood decreases after 24 hours
Hirschsprung Disease
Congenital aganglionic megacolon- no neurons in anal sphincter causing functional obstruction>dilation with gas and feces
MC chromosomal abnormality associated with hirschsprung disease?
Down syndrome
Presentation of Hirschsprung disease
Usually in infants: Failure to pass meconium followed by vomiting, abdominal distention and reluctance to feed, bilious emesis
Explosive expulsion of gas and stool after DRE
Hirschsprung disease in older kids
Constipation alone-foul smelling ribbonlike stools, no visible stool on anal and rectal exam
Hirschsprung diagnosis
Rectal biopsy: lack of neurons
X-ray-dilated proximal colon w/out gas in pelvic colon
Barium enema: dilated colon, narrow distal segment with sharp transition to normal colon
Hirschsprung treatment
Surgical removal of aganglionic bowel, reconstruction
Leads to fecal incontinence, retention, constipation and enterocolitis
Meckel’s Diverticulum
Bulge in small intestine containing cells from stomach and pancreas
rule of 2’s: 2 inches long, 2 feet from ileocecal valve, occurs after 2 years old
Whats the most common congenital anomaly of the GI tract?
Meckels diverticulum
Presentation of Meckels diverticulum
Usually asymptomatic
PAINLESS lower GI bleed, can mimic appendicitis, recurrent/atypical intussusception, obstruction
Diagnosis/treatment of Meckel’s Diverticulum
CT angio or arteriography
Meckel’s scan (radionuclide)
Surgical resection IF symptomatic
Newborn Jaundice complications/treatment
Brain injury if high bili persists (kernicterus)
Treat with phototherapy, may need transfusion
Gilbert’s Syndrome
Autosomal dominant hyperbilirubinemia
Jaundice without increased bili levels (usually <3-6), normal biopsy and LFTs
Diagnosis/Treatment of Gilberts syndrome
Increase of 1.4mg unconj bili after 2 day fast
No treatment
What 4 areas does cystic fibrosis affect?
Lung, pancreas, intestine and liver
Symptoms of cystic fibrosis
Pancreas: fat soluble vitamin deficiency, diarrhea, steatorrhea
Intestine: intussusception, carb intolerance
Liver: steatosis, cirrhosis, neonatal jaundice
When to suspect cystic fibrosis?
Any child with meconium ileus, cholestasis, recurrent URI/lung disease or malabsorption
Diagnosis/treatment of cystic fibrosis
Newborn screening, sweat chloride test
Oral supplement of pancreatic enzymes, ours for cholestasis
Biliary/choledochal cysts (presentation, diagnosis, treatment)
Recurrent RUQ pain, fever, vomiting, obstructive jaundice, pancreatitis or R abdominal mass
US or MRI to diagnose
Surgery once stable
Biliary atresia
Progressive fibroinflammatory obliteration of lumen of extra hepatic biliary tree
Presentation of biliary atresia
Urine stains diaper and stools pale yellow, gray or echoic
Firm hepatomegaly common
failure to thrive by 6 months
Asians, blacks, premies in 1st 3 months
Diagnosis and treatment of biliary atresia
Ultrasound to rule out choledochal cyst Kasai procedure (hepatoportoenterostomy)
Imperforate anus
Congenital defect when opening of anus is absent or blocked
develops within 5-7 weeks of pregnancy
Presentation and treatment of imperforate anus
Infant fails to pass meconium, greenish bulging membrane obstructing anal aperture
Surgery
Pilonidal Cyst risk factors/treatment
overweight, deep cleft
Surgical opening and draining of sinus, sitz bath
Enterobiasis (pinworms)
intense ana pruritis
Scotch tape test
Pyrantel pamoate for whole family
Encopresis
repeated pooping in inappropriate places for 3 months >4 years of age
Behavioral-educational therapy
If meds needed, miralax, laxatives
Causes of chronic constipation
dehydration, excessive milk intake, lack of fiber
meds (antihistamines, narcotics)
thyroid disease, cerebral palsy
Treat with P fruits, miralax
UTI Presentation
Newborns/infants: high fever, vomiting, jaundice, cloudy foul smelling urine
preschool kids: abd/flank pain, vomiting, fever, frequency, dysuria, enuresis; CVA tenderness unusual
School aged: frequency, dysuria and urgency; pyelonephritis with fever, vomiting, flank pain, CVA tenderness
UTI Diagnosis
Urine culture of midstream clean catch, may need catheter
UTI Treatment
<3 months, dehydrated or septic: admit for IV antibiotics
Older: empiric amoxicillin, bactrim, reflex for 7-10 days
Vesicoureteral reflux
reflux of urine from bladder into upper urinary tract
common in kids with febrile UTI <2 years old
Short ureters is MC form, then blockage