Peds 1 Flashcards
Viral Particles
Small virus particles with no viral DNA
Subunit Vaccine
Viral proteins only
Toxoid
Inactivated toxin stimulates antibody production
Vaccine Contraindications
mod-severe illness regardless of fever, egg or chicken allergy for influenza
Live vaccines: pregnancy and compromised immunity
If you don’t get live vaccines together, how long should you wait between?
28 days
Meningococcal Conjugate Vaccine (MCV4) Schedule
First dose: age 11-12
Booster: 16
Vaccinate ALL college students in dorms who don’t have it yet
Meningococcal Conjugate Vaccine (MCV4) Contraindications
Latex allergy, history of allergy to diphtheria, history of Guillain-Barre
Live-Attenuated Influenza vaccine (FluMist) Schedule
Yearly age 2-49 if healthy, better in 2-8 than inactivated
Given intranasally
FluMist Contraindications
Severe allergic reaction, taking aspirin and allergic to eggs, pregnant, immunosuppressed, kids 2-4 with asthma/wheezing in past 12 months, taken flu antivirals in last 48 hours
Synagis (RSV prophylaxis)
Only given to high risk babies <2
Given monthly through the fall, very expensive
Abnormal Vaccine Reactions
Inconsolable >3hours, high fever >104-105, seizure, neurological abnormalities, anahylaxis
Vaccine Side Effects (normal)
Fussiness <3 hours, tired, low fever <101.5, injection site pain, redness, swelling
Roseola infantum (erythema subitum) cause and treatment
Caused by herpes virus 6 or 7 Treated symptomatically (fever control, fluids)
Roseola Infantum Presentation
6 months-3 years with abrupt high fever for 3-7 days that stops abruptly followed by rosy-pink maculopapular rash that starts on trunk, not itchy and blanches
Adenopathy and URI findings
Erythema Infectiosum (fifth disease) Cause and Treatment
Caused by Human Parvo B-19 Treated symptomatically (fluids, antiemetics, etc)
Erythema Infectiosum Presentation
Mild-mod fever, headache, nausea, diarrhea followed in 2-5 days with “slapped cheeks” and lace-like rash on trunk and limbs
Oral Candidiasis (thrush) Casuative agent and treatment
Candida albicans
Treated with nystatin suspension, treat mom as needed (if breastfeeding)
Oral candidiasis Presentation
Adherent white plaques (thrush won’t brush) with underlying red mucosa that will bleed
Decreased feeding
Enterobiasis (pinworms) causative agent and treatment
Enterobus vermicularis
Treat whole family with 100mg Mebendazole once, repeat in 2 weeks, wash sheets in hot water
Enterobiasis Presentation
Can be asymptomatic
Anal itching esp at night
Enterbiasis Diagnosis/Prevention
Scotch tape test
Prevent with hand washing, short nails, avoid scratching anus
Molluscum Contagiosum Causative Agent and Treatment
Poxvirus
Treat with curettage, cryotherapy, cantharidin, podophyllotoxin, retinoids, salicylic acid, lasers
Molluscum Contagiosum Presentation
Flesh-colored dome-shaped papule with central umbilication
Bacterial Meningitis
Emergency, fatal if untreated
Bacterial Meningitis Pathogen in 1-3 month olds
Group B strep
Bacterial Meningitis Pathogen in 3 months-3 year olds
S pneumoniae
Bacterial Meningitis Pathogen in3-10 year olds
S. pneumoniae
Bacterial Meningitis Pathogen in 10-19 year olds
N. Meningitidis
Bacterial Meningitis Presentation
High fever, irritable, anorexia, headache, confusion, photophobia, back pain, nuchal rigidity
Petechial rash that does not blanch in N meningitides
Viral Meningitis
Presents similar to bacterial-it is bacterial until proven otherwise!
Humoral immunodeficiency
Impaired antibody(Ig) production
Presentation of immunodeficiency
Recurrent severe respiratory infection (OM, sinusitis, pneumonia), poor growth, failure to thrive, unexplained splenomegaly, chronic diarrhea
What is the most common immunodeficiency?
Selective IgA deficiency (w/ normal IgG and IgM in a child >4 years)
Presentation of IgA deficiency
Most are asymptomatic
Recurrent sinopulm infections, autoimmune disorders, GI infections (giardiasis), allergic disorders, anaphylactic transfusion reactions, celiac
Refer to immunology
Common Variable Immunodeficiency (CVID)
Impaired B-cell, T-cell and dendritic cell production leading to impaired Ig production
CVID Criteria
Reduced serum IgA, G and M
Poor response to vaccines, presence of B-cells, absence of other immunodeficiency
CVID Presentation
Usually presents around puberty
Chronic/recurrent rest infections, GI infections, Failure to thrive (diarrhea, malabsorption, weight loss), atopic triad
CVID Management
Refer to immunologist, IVIG
Severe Combined Immunodeficiency (SCID)
Severe defect in both T and B lymphocyte systems leading to early death from infection
X-linked (males only)
Part of newborn screen in all states
SCID Presentation
One or more severe infections in first few months of life, may become ill from live vaccines (varicella, MMR, OPV (polio) or RV (rotavirus))
May not have visible thymus on chest xray
SCID Manifestations and Therapy
Persistent thrush, P jirvecii infection, lymphoma, death from viral infections
Stem cell transplant, managed by immunology
DiGeorge Syndrome
Chromosomal deletion of 22q11.2 affecting multiple body systems
Most prevalent micro deletion syndrome in US
DiGeorge Syndrome Defects/Presentation
Cyanosis (tetralogy of fallout, ASD, VSD, interrupted aortic arch)
Immune dysfunction (Cell deficits, hypo plastic thymus)
Cleft palate
Hypocalcemia (parathyroid hypoplasia, tetany, seizure)
Wiskott-Aldrich Syndrome
X-linked disorder caused by mutation in WASp protein
Wiskott-Aldrich Presentation
Susceptibility to infections, thrombocytopenia, eczema
Can develop malignancy, autoimmune disease
Wiskott-Alsdrich Treatment
Stem cell transplant is only curative
Prophylactic antibiotic and antiviral (bactrim+acyclovir), platelet transfusions as needed, Ig if needed
Ataxia-Telangiectasia Presentation
Don’t develop fluidity of gait, telangiectasis of conjunctiva, face and neck, swallowing problems/aspiration, malignancy (lymphomas), nystagmus
Treat each manifestation individually
When are the recommended well visits?
birth, 1 month, 2mo, 4mo, 6mo, 9mo, 12mo, 15mo, 18mo, 2years and then annually
What percentiles are considered Overweight, obese and underweight?
overweight: 85-95%
Obese: >95%
Underweight: <5%
What are the head size percentiles?
Microcephaly: <3%
Macrocephaly: >97%
Birthweight classifications
Extremely low: <1000g/2.2lbs
Very low: <1500g/3.3lbs
Low: <2500g/5.5lbs
Normal: >2500g
Classification of gestational age
Preterm: <37 weeks
Term: 37-42 weeks
Postterm: >42 weeks
Apgar Score
Key newborn assessment immediately after birth. Retested every 5 minutes until score is >7
Newborn Screen
Heel stick before discharge and at 1-2 weeks to test for metabolic and genetic diseases
What is vernix caseosa?
Cheesy white covering made from fetal corneocytes and sebaceous gland activity and risk lipid matrix
Milia
Pinpoint white papule without surrounding erythema caused by blocked sebaceous glands, disappears on its own
Mongolian Spot
Congenital dermal melanocytes; blue patches of pigment seen over lumbar area, buttocks or extremities, fade with time
Common in Asian, both Indians, Mexicans and blacks
Erythema Toxicum
Yellow eosinophilic papule on red base that appear on trunk, face and forehead on day 2-4, disappear within 1 week
What can abnormal fontanelles indicate?
Bulging: increased ICP
Sunken: dehydration
Large: hypothyroidism
Raised bony ridge: craniosynostosis
Cephalohematoma
Swelling/collection of blood over one or both parietal bones, does not cross suture line, resolves in weeks-months
Caput Succedaneum
Edema of the scalp, can cross suture lines, resolves in days
Epstein’s pearls
Small, white benign inclusion cysts typically seen on palate between 2-4months
Bohn nodules seen on gingival ridge
Resolve spontaneously
Ankyloglossia
Congenital short lingual frenulum that can limit movement of tongue and pain with nursing
Usually see a puckering of the midline tongue tip
Treat with frenotomy/frenulotomy in neonatal period
Congenital Torticollis
head tilted with chin pointing in opposite direction, results from bleeding into sternocleidomastoid during stretching process of birth, appears as firm fibrous mass within the muscle, disappears over months
Pectus excavatum
sternal depression
M>F (x3)
Pectus carinatum
Chicken breast deformity or pigeon chest
M>F (x4)
Findings that may indicate cardiac disease
Poor feeding, failure to thrive, irritability, tachypnea, hepatomegaly, clubbing, poor overall appearance, weakness
What is the most common dysthymia?
Paroxysmal supra ventricular tachycardia (PSVT)
Hypospadias
Abnormal ventral urethral placement-check for this before circumcision
Epispadias
Abnormal dorsal urethral placement-check for this before circumcision
What can a sacral dimple indicate?
Spina bifida-need to ultra sound if you can’t see the base
What can a single palmar crease indicate?
AKA simian crease
associated with trisomy 21
Developmental Dysplasia of the Hips risk factors
Breach, 1st born white female, family history, prematurity
Developmental Dysplasia of the Hips evaluation/Treatment
Audible click heard with Barlow or Ortolani
Treat with Pavlik harness and ortho eval
Barlow Test
Test for ability to sublet or dislocate intact but unstable hip-bring bent leg medial
Ortolani Test
Tests for posteriorly dislocated hip-pull bent leg laterally
Age for Palmar Grasp
birth to 3-4 months
Age for plantar grasp reflex
Birth to 6-8 months
Moro Reflex (startle reflex)
“drop” baby while holding supine, arms should flail and legs flex
Birth-4 months
Moro Reflex abnormalities
Persistence beyond 4-6 months could be neuro disease
Asymmetric response could be fractured clavicle or brachial plexus injury
Asymmetric Tonic Neck Reflex
Baby supine, turn head to one side with jaw over shoulder-arms/legs on that side extend, opposite side flex
Birth-2 months
Asymmetric tonic neck reflex abnormalities
Persistence beyond 2 months could be asymmetric central nervous system development
Positive Support Reflex
Hold baby and touch feet to surface-hips knees and ankles extend and baby stands
Birth/2 months-6 months
Lack of reflex could be hypotonia or flaccidity
Rooting reflex
Stroke personal skin at corners of mouth, mouth will open and baby will turn toward that side
Birth-3/4 months
Trunk Incurvation (Galant’s reflex)
Hold baby prone and stroke one side of back from shoulder to butt, spine will curve toward that side
Birth-2 months
Absence could be transverse spinal cord lesion/injury
Placing and Stepping Reflexes
Hold baby and have one foot touch table, that hip/knee will flex and other will step forward-alternate stepping
Birth-variable age
What is the most common cause of childhood blindness
Amblyopia
When do we start checking BP
3 year well visit unless other risk factors (kidney disease, premie, CHD, recurrent UTIs, etc)
When/why to screen hemoglobin?
for iron deficiency: 9 or 12 months
When/why to test for lead?
Ages 1-2, it could cause learning and developmental delays
When do we screen for autism?
18 and 24 months
Fasting Lipid screening ages/recommendations
Between 2-10years if risk factors present (FH of hyperlipidemia, early CV, obesity, HTN, diabetes)
When should first dental visit be?
Between 12 months-3 years
How long should baby be rear facing in car seat?
until 2 years, booster until 4’9”
1 month Milestones
fix/follow, some head control, responds to noises spontaneous smile
2 month Milestones
Responsive smile, coos, lifts head when prone, follows to midline
4 month Milestones
Rolls from tummy to back, good head control, laughs, follows past midline, grasps object
6 month Milestones
Sits with support, bears weight on legs, reaches for toys, follows 180 degrees, separation anxiety
9 month Milestones
Crawls, says mama/dada, pincer grasp, responds to name, pulls up/walks on furniture
12 month Milestones
Can start walking, self feeds with fingers, waves, points
15 month Milestones
3-6 words, walks well, climbs stairs, imitates
18month Milestones
Some 2 word phrases, scribbles, follows simple commands, uses spoon/fork, runs/walk backwards
24 month Milestones
20-50 words, kicks ball, build with blocks, 50% speech understandable
Vaccines at 2 and 4 months
RV, Tdap, Hib, PCV13, IPV (polio)
Hep B Vaccine Schedule
3 doses: at birth, 1-2 months, 6-8 months
Hep B Vaccine Contraindications/AEs
Severe yeast allergy
Can cause fever, injection site pain
Rotavirus Vaccine Schedule
Live oral vaccine- 2, 4 and 6 months
Rotavirus Vaccine Contraindications/AEs
History of intussusception, infant with SCID, mod-severe gastro
AEs: increased risk of intussusception, vommiting and diarrhea, cough, runny nose
Tdap Vaccine Schedule
5 total-2, 4, 6, 15/18 months and 4 years
Tdap Vaccine Contraindications/AEs
Encephalopathy, unstable neurological disorders, high fever with previous vaccine
AEs: swelling and redness at sire, fever