Pedigrees Flashcards
Q: What is Autosomal Recessive inheritance?
A: Trait appears only in individuals who inherit two copies of the mutant allele (one from each parent); often skips generations, unaffected carriers can have affected children
Q: What is a key feature of Autosomal Dominant inheritance?
A: Trait appears in every generation; affected individuals usually have at least one affected parent.
Q: What is X-Linked Recessive inheritance?
A: Mostly affects males; females can be carriers; no male-to-male transmission, can skip gens, males pass affected x to daughters
Q: What is X-Linked Dominant inheritance?
A: Affects both sexes; all daughters of an affected male are affected, but none of his sons, sons only affected if mother is affected, in every gen
Q: How do you identify Autosomal Recessive traits in a pedigree?
A: Unaffected parents can have affected children; often appears in siblings but not in parents.
Q: How do you identify Autosomal Dominant traits in a pedigree?
A: Trait does not skip generations; affected parent passes to about 50% of offspring.
Q: How do you identify an X-Linked Recessive trait in a pedigree?
A: Trait skips generations, males are more often affected, and carrier females can pass it to sons.
Q: How do you identify an X-Linked Dominant trait in a pedigree?
A: Affected fathers pass trait to all daughters, never sons; affected mothers pass to both sons and daughters.
