Pediatrics Flashcards
At delivery, give newborns…
- 1% silver nitrate or 0.5 erythromycin ophthalmic ointment
- 1mg of Vitamin K to prevent hemorrhagic disease
Before discharge, one should do the following:
- Perform hearing tests to r/o congenital sensorineural hearing loss
- Order neonatal screening tests
Neonatal screening tests
- Phenylketonuria
- Galactosemia
- Hypothyroidism
- best done after 48 hrs
APGAR Score
- measure of the need and effectiveness of resuscitation
- 1 minute score gives idea of what was going on during labor and delivery
- 5 minute score gives an idea of response to therapy
Mongolian Spots
- blue/gray macules on presacral back/posterior thighs
- usually fade in first few years
- must r/o child abuse
Erythema toxicum
- firm, yellow white papules/pustules with erythematous base, which peak on 2nd day of life
- usually self limited
Port wine stain (Nevus flamus)
- permament, unilateral vascular malformation on head and neck
- associated with Sturge Weber syndrome (AV malformation results in seizures, mental retardation and glaucoma
- can give pulsed labor therapy
- If Sturge Webser, evaluate for glaucoma and give anticonvulsives
Hemangioma
- red sharply demarcated raised lesions appearing in first 2 months, rapidly expanding then involuting by 5-9 yrs
- consider underlying organ involvement with deep hemangiomas
- if it involves larynx, can cause obstruction
- may cause high cardiac output when large
Tx of hemangioma
- treat with steroids or pulsed laser therapy if large or intereferes with organ function
Periauricular tags/pits
- associated with hearing loss
- genitourinary abnormalities
- further evaluate with hearing test and U/S of kidneys
Coloboma of the iris
- defect in the iris
- associated with CHARGE syndrome
- make sure to screen for CHARGE syndrome
CHARGE syndrome
- Colonoma
- Heart defects
- Atresia of the nasal choanae, growth
- Retardation
- Genitourinary abnormalities
- Ear abnormalties
Aniridia
- absence of the iris
- associated with Wilms’ tumor
- screen for Wilms’ tumor with abdominal U/S q3 months until age 8
Branchial cleft cyst
- mass lateral to midline
- remnnt of embryonic development associated with infxns
- tx with surgical removal
Thyroglossal duct cyst
- mass midline that moves with swallowing
- associated with infections
- may have thyroid ectopia
- tx with surgical removal
Omphalocele
- GI tract protrusion through umbilicus WITH sac
- caused by failure of GI sac to retract at 10-12 weeks
- associated with malformations and chromosomal disorders
- screen for trisomies 13, 18, and 21
Gastrochisis
- abdominal defect lateral to midline WITHOUT sac
- associated with intestinal atresia
Umbilical hernia
- congenital weakness where vessels of fetal and infant umbilical cord exited through rectus abdominal muscle
- associated with congenital hypothyroidism
- screen with TSH
- may close spontaneously (usually by 2)
Hydrocele
- scrotal swelling, transillumination
- associated with inguinal hernia
- must differentiate from inguinal hernia
Undescended testes
- unilateral absences in scrotal sac
- associated with malignancy if > 1 yr of age
- tx with surgical removal
Hypospadias
- urethral opening on ventral surface
- associated with other GU abnormalities (MCC is undescended testes and inguinal hernia)
- DO NOT CIRCUMCISE
Epispadias
- urethral opening on DORSAL side of penis
- associated with urinary incontinence (form of urinary exstrophy)
- tx with surgical evaluation for bladder exstrophy
Inguinal hernia
- usually indirect
- inguinal bulge or reducible scrotal swelling
- tx with surgery
Pt is 9.5lb newborn who is jittery. Pregnancy complicated by prolonged delivery w/ shoulder dystocia. PE shows large plethoric infant who is tremulous. Pan-systolic murmur is heard. What’s most appropriate diagnostic test?
Blood glucose
- Child is likely infant of diabetic mother
Newborns of diabetic mothers
- Look for macrosomia (enlarged organs)
- Hx of birth trauma and cardiac abnormalities
- tx with glucose and small, frequent meals
Lab abnormalities: infant of diabetic mother (IODM)
- Hypoglycemia (after birth)
- Hypocalcemia
- Hypomagnesmia
- Hyperbilirubinemia
- Polycythemia
IODM associated with which cardiac and GI abnormalities?
- ASD
- VSD
- Truncus arteriosus
- Small left colon syndrome (abdominal distention)
IODM is associated with what risks for child?
Increased risk of developing diabetes and childhood obesity
Newborn is in respiratory distress. Best initial therapy?
Chest X-ray
Other diagnositic tests to consider in newborn in resp distress?
- ABG
- Blood cx (r/o sepsis)
- Blood glucose (r/o hypoglycemia)
- CBC (r/o anemia or polycythemia)
- Cranial U/S (intracranial hemorrhage)
Best initial treatment for newborn in respiratory distress?
- Oxygen: keep SpO2 > 95%
- Give nasal CPAP if high oxygen requirements to prevent barotrauma and bronchopulmonary dysplasia
- Consider empiric abx for suspected sepsis
If newborn in respiratory distress is still hypoxic with oxygen therapy, next cause?
Evaluate for cardiac causes
Clinical fx of premature neonate in respiratory distress
- Tachypnea
- Nasal grunting
- Intercostal retraction within hours of birth
- HYPOXEMIA
- Eventually hypercarbia and respiratory acidosis develop
Best initial diagnositc test for newborns in respiratory distress?
CXR: ground glass appearance, atelectasisa, air bronchograms
Most accurate test for respiratory distress :
Lecithin-sphingomyelin (L/S) ration on amniotic fluid prior to birth
Best initial treatments for newborn in respiratory distress?
Oxygen and nasal CPAP
Most effective treatment for newborn in respiratory distress?
Exogenous surfactant adminitstration (proven to decrease mortality)
Primary prevention of newborn RDS
- Antenatal betamethasone: most effective if > 24 hrs before delivery and < 34 gestations
- Avoid prematurity: give tocolytics
- Postnatal corticosteroids do not help and are not indicated
Complications of newborn RDS
- Retinopathy of prematurity 2/2 hypoxemia
- Bronchopulmonary dysplasia 2/2 prolonged high-concentration oxygen
- Intraventricular hemorrhage
If fetus is in danger of preterm delivery < 34 weeks, next step?
Give corticosteroids
Transient Tachypnea of the Newborn (TTN)
- presents as tachypnea after a term birth of infant delivered by Cesarean section or rapid second stage of labor
Diagnostic test for TTN
Perform CXR to look for:
- air trapping
- fluid in fissurs
- perihilar streaking
Best initial treatment for TTN
Oxygen (minimal requirements need) results in rapid imporovement within hours to days
Birth weight
- normally doubles by 6 months
- triples by 1 year
Height percentile
- at 2 years of age normally correlates with final adult height
Best indicator for acute malnutrition
Weight/height < 5th percentile
Best indicator for under- or overweight
BMI
Skeletal maturity
- correlates with sexual maturity (less related to chronological age)
Most common cause of failure to thrive in all age groups
Psychosocial deprivation
Ddx: Low weight gain»_space; Low length/height
- Undernutririon
- Inadequate digestion
- Malabsorption (infxn, celiac disease, cystic fibrosis, disaccharide deficiency, protein-losing enteropathy)
Workup: low weight gain»_space; decreased length height
- Assess caloric intake
- Perform stool studies for fat
- Perform sweat chloride test
Ddx:
Normal weight Low length/height
- Growth hormone or thyroid hormone deficiency
- Excessive cortisol secretion
- Skeletal dysplasia
Workup: for normal weight, low length/height
-Growth hormone deficiency
- IGF-1 and IGF-binding protein
Thyroid hormone
- TSH, free T4, free T3
Cushings
- 24 hr urinary cortisol or free cortisol
Bone age (X-ray of hand and wrist)
- Skeletal dysplasia: no delay in bone age and disproportionate bone length on exam
Meconium aspiration
- severe respiratory distress and hypotexmia and TERM neonate with hypoxia or fetal distress in utero
Meconium aspiration: Diagnosis
Chest X Ray Look for: - patchy infiltrates - increased AP diameter - flattening of diaphragm
Meconium aspiration: treatment
- Positive pressure ventilation
- High frequency ventilation
- Nitric oxide therapy
- Extracorporeal membrane oxygenation
Meconium aspiration: prevention
Endotracheal intubation and airway suction for depressed infants
Possible complictations of meconium aspiration
- Pulmonary artery hypertension
- Air leak (pneumothorax, pneumomediastinum)
- Aspiration pneumonitis
Diaphragmatic Hernia
severe respiatory distress and scaphoid abdomen (distress related to pulmonary hypoplasia)
Diaphragmatic Hernia: Diagnostic Testing
Chest X-ray
- look for loops of bowel visible in the chest
Diagphramatic Hernia: Treatment
Immediate intubation (may require extramembrane corporeal oxygenation), followed by surgical correction
Meconium plugs
presents initially as intestial obstruction
Meconium plugs associated with the following conditions
- Small left colon in IODM
- Hirschsprung disease
- Cystic fibrosis
- Maternal drug abuse
Meconium ileus: associated w/ which conditions?
Cystic fibrosis
Best diagnotic test for meconium plug or meconium ileus
Abdominal X-ray
Meconium plug/ileus: treatment
Gastrografin enema
Newborn is born by normal vaginal delivery w/o complications. There is no RDS. Upon first feed, he is noted to have prominent drooling: he gags and develops RDS. CXR shows infiltrate on the lung. Which of the following best confirms the diagnosis?
Nasogastric tube placement
- Pt has tracheoesophageal fistula
Premature infant is born by normal vaginal delivery w/o complications. There is no RDS. Upon her first feed, she begins vomiting gastric and bilious material. CXR show “double bubble. Most likely diagnosis?
Duodenal atresia
- associated w/ Downs syndrome
- treat w/ nasogastric decompression and surgical correction
VACTERL abnormalities
Vertebral defects Anal atresia Cardiac abnormalities Tracheoesophageal fistula Radial and renal anomalities Limb Syndrome
Ddx: Double bouble seen on CXR
- Duodenal atresia
- Annular pancreas
- Malrotation
- Volvulus
Necrotizing Enterocolitis
- premature infant with low APGAR scores, bloody stools, apnea, and lethargy when feeding is started
- abdominal wall erythema and distention are signs of ischema
Best initial test for necrotizing enterocolitis?
Abdominal X-ray
** pneumatosis intestinalis is pathognomonic
Intial therapy for necrotizing enterocolitis
- Stop all feeds
- Decompress the gut
- Begin broad spectrum abx
- Evaluate for surgical resection
Best initial test if infant fails to pass meconium
Rectal exam
Newborn fails to pass meconium on own however with DRE, patient passes large volume of stool. Suspected dx?
Hirschsprung
If newborn fails to pass meconium. How should one proceed?q
- Digital rectal exam
- Barium enema (look for megacolon proximal to obstruction)
- Rectal biopsy
Best confirmatory test for Hirschsprung disease
Rectal biopsy ( tlook for absent ganglionic cells)
Hirschsprung disease: treatment
Surgical resection
If newborn fails to pass meconium and DRE shows absent anal opening. What’s the treatment?
Imperforate anus
- surgical treatment is best treatment
When is hyperbilirubinemia considered pathological ?
- On the first day of life
- Bilirubin > 5mg/dL/day
- Bilirubin > 12mg/dL in term infant
- Direct bilirubin > 2 mg/dL at any time
- Hyperbilirubinemia is present after 2nd week of life
Hyperbilirubinemia in 3 week old infant
- Total and direct bilirubin
- Blood type of infant and mother: Look for ABO or Rh incompatibility
- Direct Coombs’test
- CBC, reticulocyte count, and blood smears: Assess for hemolysis
- Urinalysis and UCx if elevated direct bilirubin: assess for sepsis
Most feared complication of jaundice (2/2 to elevated indirect bilirubin)
Kernicterus
- Indirect bilirubin can cross BBB, deposit in basal ganglia and brainstem nuclei
-
Kernicterus: Sx
- Jaundice
- Hypotonia
- Seizures
- Opisthotonos
- Delayed motor skills
- Choreaoathetosis
- Sensineural hearing loss
Kernicterus: Treatment
Immediate exchange transfusion
If prolonged jaundice (> 2 weeks) workup w/ no elevated of indirect bilirubin, consider the following diagnoses:
- UTI or other infxn
- Bilirubin conjugation syndromes (e.g. Gilbert, Crigler-Najjar)
- Hemolysis
- Intrinsic red cell membrane or enzyme defects (e.g. spherocytosis, G6PD deficiency)
If patient has prolonged jaundiced with elevation of conjugated bilirubinemia. What’s most likely diagnosis?
Cholestasis
Best initial test for suspected cholestasis
Liver function tests
Most specific test for cholestasis
Ultrasound and liver biopsy
Hyperbilirubinemia: Treatment
Phototherapy: when bilirubin > 10-12 mg/dL (normally decreases by 2 mg/dL every 4-6 hrs)
Exchange transfusion in any infant with suspected bilirubin encephalopathy or failure of phototherapy to reduce total bilirubin
5 week old infant is brought into the clinic with irritability, weight loss of 3 lbs over the past week and “grunting. PE reveals temperature of 102.5F. There is a bulging anterior fontanel delayed capillary refill. What is the next step of management?
Transfer patient to ER and initiate full sepsis workup
Most common cause of early onset sepsis (< 24 hrs) is..
Pneumonia
Organisms seen in early onset neonatal sepsis
Group B Strep
E.coli
H. influenxa
Listeria monocytogenes
Organisms seen late onset neonatal sepsis
S. aureus
E. coli
Klebsiella
Pseudomonas
Neonatal Sepsis: Treatment
If no evidence of meningitis, ampicillin and aminoglycoside until 48 to 72 hr cx are negative
If meningitis is possible, ampicillin and 3rd generation cephalosporin (NOT ceftriaxone)
General features of TORCH infections
- intrauterine growth retardation
- hepatosplenomegaly
- jaundice
- mental retardation
Diagnostic workup of TORCH infections
Elevated total cord blood IgM
Toxoplasmosis
hydrocephalus with generalized intracranial calcifications and chorioretinitis
Toxoplasmosis: Diagnostic Workup
IgM against toxoplasmosis
Rubella
- cataracts, deafness, and heart defects
- blueberry muffin spits (extramedullary hematopoeisis)
Rubella: Diagnostic Workup
Maternal rubella immune status negative or unknown – obtain IgM against rubella
CMV
microcephaly with periventricular calcifications
- petechiae with thrombocytopenia, sensorineural hearing loss
CMV: Diagnostic workup
Urine CMV Cx - if negative, excludes CMV
Herpes
First week: pneumonia/shock
Second week: skin vesicles, keratoconjunctivitis
Third to Fourth week: acute meningoencephalitis
Herpes: Diagnostic Workup
Best initial tests: Tzanck smear/ culture (doesn’t exclude disease if negative)
Most specific test: PCR
Syphillis
osteochondritis and periostitis
desquamating skin rash of palms and soles, snuffles (mucopurulent rhinitis)
Syphillis: Diagnostic Workup
Best initial test: VDRL screening
Most specific test: IgM-FTA-ABS
Varicella
Neonatal: pneumonia
Congenital: Limb hypoplasia, cutaneous scars
Varicella: Diagnostic workup
Best initial test: IgM serology
Most specific test: PCR of amniotic fluid
In newborn ICU, an infant is noted to be “jittery” and has repetitive sucking movements, tongue thrusting, and brief apneic spells. Blood counts and chemistries are within normal limits. What is the initial workup of this patient?
Ocular deviation and failure of jitteriness to subside with stimulus
This is a seizure (with subtle repetitive movements)
Seizure: Diagnostic Workup
- EKG
- CBC, electrolytes
- Amino assay and urine organic acids
- Look for infectious causes
- TORCH infection studies
- Blood and urine cx
- Lumbar puncture
- U/S of head in preterms
Seizures: Treatment
Phenobarbital (initial drug of choice)
If seizures persist, use phenytoin
Neonatal Withdrawal
Presents with
- hyperactivity, irritability
- diarrhea,
- poor feeding
- tachypnea
- high pitched crying
Withdrawal timing: heroin, amphetamine, cocaine, and alcohol
Presents within the first 48 hrs of life
Withdrawal timing: methadone
Presents within the first 96 hrs (up to 2 weeks). Drug associated with higher risk of seizures
Infants of addicted mother are at higher risk of following complications
- Low birth weight
- Intrauterine growth restriction (IUGR)
- Congenital anomalies (alcohol, cocaine)
- Sudden infant death syndrome (SIDS)
Complications of mother’s conditions
- Sexually transmitted diseases
- Toxemia
- Breech
- Abruption
- Intraventricular hemorrhage (cocaine use)
Neonatal withdrawal: Treatment
Best initial treatment: opioids (esp if specific prenatal opioid use was known) and phenobarbital
Why do you never give naloxone to an infant born from mother with known narcotics use?
It may precipitate sudden withdrawal, including seizures
Fetal defects: Anesthetics
Respiratory, CNS depression
Neonate: Barbituates
Respiratory, CNS depression