Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

MSK 2 > Pediatric Rheumatology > Flashcards

Pediatric Rheumatology Flashcards

1
Q

Dx of JIA

A

Need arthritis for at least 6 weeks in a child less than 16 y/o when other causes ruled out

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

JIA complications

A

Persists into adult

Uveitis is serious

Uncontrolled leads to growht probs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

JIA pathogenesis

A

Iiodpathic

Genetic,

immunological (altered immunity or immune dysregulation)

environment (infection, trauma, stress, perinatal/prenatal exposures)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Genetic factors of JIA

A

PTPN22, IL2RA/CD25

HLA associations

Down syndrome (trisomey 21)
Turner syndrome (45,XO)
Velocardiofacial syndrome (del 22q11.2)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Uveitis and JIA

A

Young female (think toddler) oligo-JIA and patients who are ANA+ are most at risk

Sometimes prior to onset of arthritis

Usually asymptomatic

Can get postierior synechiae, cataracts, band keratopathy, glaucoma, loss of vision

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is uveitis?

A

Mostly in the anterior chamber in JIA

Get inflammation of anterior chamber…iris develops adhesions to the lens…can even have damage to ciliary body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Uveitis managment of JIA

A

Need regular slit lamp exams to screen…depends n subtype and other factors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How does JIA present

A

Joint swelling, pain (typically not in JIA), morning stiffness

Limp, revert to infantile movement patterns, refuse to perform activities, troulbe keeping up with peers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Exam on JIA

A

Inflammatory signs

Grwoth distrubance….increased growht of long bones and premature fusion of grwoth plates in small bones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Systemic JIA dx

A

DIagnosis is any number of joints with a fever more than 2 weeks that is daily for 3 days and accompanied by

Rash
LAD
Hepato/splenomegaly
Serositis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

sJIA epidemiolgy

A

Onset before 5y/o
Males and females equal
Autoinflammatory dz
Bloodwork with inflammation but ABs negative

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

sJIA complications

A

Rash is most common…migratory and transient and exhibits koebner phenoone…might look like urticaria and if you touch or scratch, rahs will appear

No uveitis normally

Growth retardation/macrophage activation syndrome…maybe amyloidosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Oligo-JIA dx

A

Arthrtis in less than 4 joints during the 6 mos of dz

Persistent - never more than 4 joints

Extended - more than 4 joints affected after the first 6 months of dz

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Oligo-JIA epi and other dx

A

More in females
Around 1-2 y/o

Usually lower extremity involvement

Most ANA positive

Uveitis in about 20%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

POly-JIA dx

A

Arthritis affecting more than 5 joints during first 6 mos of the disease

RF- neg

RF-pos - test is positive more than 2 times more than 3 months apart during 1st 6 months of the dz

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

POly-JIA epi

A

MOre in females…especially in RF positive

17
Q

PlyJIA neg onset and epi

A

1-3 y/o onset, or later childhood/adolescence

Mild systemic faetures

May be asymmetric

All RF neg, ANA+ on 50%

15% uveitis

18
Q

Poly-JIA RF positive onset and epi

A

9-11 y/o

Clinically similar to RA

Aggressive nad may be symmetric

All RF+, CCP+ in 75%, ANA+ in 75%

Uveitis uncmmon

19
Q

Infection diff dx

A

Viruses - parvo B19, EBV, CMV…tend to be more acute

Bacteria - septic arth, neisseria gonorrhoeae, TB

20
Q

Transient synovitis

A

Often preceded by an URI

More in boys 3-10 y/o

Pain can be sudden/gradual and lasts about 6 days

Unilateral hip pain is most common

21
Q

Transient synovitis dx

A

ESR and WBC normal

Joint fluid normal or slight increase in WBC

X-ray/US/MRI may show joint effusion…x-ray cannot rule out

Manage with NSAIDs and rest

22
Q

Systemic dz dx

A

Malignancy
IBD

SLE
Sarcoidosis
Vasculitis - look for HSP - palpable purpura, ab pain, renal dx, periarticular soft tissue swelling

23
Q

JIA management

A 
NSAIDs
Steroids
DMARDs
Biologics
PT/OT

Uveitis screening

24
Q

JIA outcomes in general

A

50% into adults

50% without diability

25
Q

sJIA outcomes

A

50% monocyclic

50% have a persistent disease course

Not much death

MSK 2 (24 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions