Pediatric lymphoma and leukemia - Newman Flashcards
what is the MCC cancer among US children?
ALL
what is the MC cancer in adolescents?
lymphoma
what is the MC cancer in younger children?
leukemia
what is the MC malignancy in 15-19y/o’s?
HL
- transport of fat throughout the body
- transport of interstitial fluid back to circulatory system
- usually caused by EBV infection
- REED-STERNBERG CELLS (large cell with multiple/multilobulated nuclei = OWLS EYES)
what are the clinical B symptoms of HL?
- unexplained fever >39 C
- wt loss >10% total body wt over 6 months
- drenching night sweats
any pt with persistent, unexplained LAD unassociated with obvious underlying inflammatory or infectious process should undergo what test?
radiography
- to rule out mediastinal mass before undergoing LN bx
recurrent sino-pulmonary and ear infections (x-linked recessive)
- severe atopic dermatitis
- bleeding (secondary to significant thrombocytopenia)
wiscott-aldrich syndrome (x-linked recessive)
this form of NHL commonly manifests as abdominal (sporadic) or head and neck disease (endemic) with involvement of the bone marrow or CNS
burkitt lymphoma
what is prognosis of patients with localized NHL?
90-100% chance survival
what is the prognosis of advanced NHL?
60-95% chance survival
- depends on pathologic subtype, tumor burden at diagnosis as reflected in serum lactate DH (LDH), presence/absence of CNS disease, and specific sites of metastatic spread
what accounts for the greatest percentage of cases of childhood malignancies?
leukemia
results from malignant transformation and clonal expansion of hematopoietic cells at an early stage of differentiation that are then unable to undergo further maturation
leukemia
lymphoid lineage cell proliferation
lymphoblastic leukemia
granulocyte, monocyte, erythrocyte, or platelet lineage cell proliferation
myeloid leukemia
what type of leukemia is commonly seen with trisomy 21?
ALL and AML
