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FTM Biochem > PDH & TCA > Flashcards

PDH & TCA Flashcards

1
Q

Where does pyruvate oxidation happen in the cell?

A

the matrix of the mitochondria

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2
Q

Where does the TCA cycle take place?

A

The matrix of the mitochondria

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3
Q

Where does oxidative phosphorylation take place?

A

Inner membrane of the mitochondria

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4
Q

What is the main substrate for the TCA cycle?

A

Acetyl-CoA

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5
Q

Name the coenzymes for the PDH complex.

A 
CoASH
FAD
NAD+
Thiamine Pyrophasphate (TPP)
Lipoic Acid
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6
Q

What is CoA derived from?

A

Vitamin B5

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7
Q

What is NAD+ derived from?

A

Niacin (Vitamin B3)

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8
Q

What is FAD derived from?

A

Flavin Adenine Dinucleotided (FAD) is derived from riboflavin (vitamin B2)

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9
Q

What activates the PDH complex?

A.  Dephosphorylation
B.  Phosphorylation
C.  Insulin in adipocytes and liver
D.  Acetyl CoA
E.  Catecholamines in cardiac muscle
F.  ATP
G.  Calcium in skeletal muscle
H.  NADH
A

Dephosphorylation
Insulin in adipocytes and liver
Catecholamines in cardiac muscle
Calcium in skeletal muscle

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10
Q

What inhibits the PDH complex?

A.  Dephosphorylation
B.  Phosphorylation
C.  Insulin in adipocytes and liver
D.  Acetyl CoA
E.  Catecholamines in cardiac muscle
F.  ATP
G.  Calcium in skeletal muscle
H.  NADH
A

Phosphorylation
Acetyl CoA
ATP
NADH

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11
Q

What activates PDH phosphatase?

A

Ca++

Mg++

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12
Q

What activates PDH Kinase?

A

NADH
ATP
Acetyl-CoA

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13
Q

What are the products of the PDH complex?

A

Acetyl-CoA
NADH
CO2

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14
Q

What are the substrates for the PDH complex?

A

Pyruvate
CoASH
NAD

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15
Q

What inhibits the TCA?

A

NADH
Acetyl CoA
Succinyl CoA

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16
Q

What activates citrate synthase?

A

Ca2+, ADP and substrate availability

17
Q

What inhibits citrate synthase?

A

ATP, NADH, succinyl CoA Fatty Acyl CoA

18
Q

What activates isocitrate DH?

A

ADP, Ca2+

19
Q

What inhibits isocitrate DH?

A

ATP, NADH

20
Q

What activates alpha-KG dehydrogenase?

A

Ca2+

21
Q

What inhibits alpha-KG DH?

A

ATP, GTP, NADH, succinyl CoA

22
Q

What activates succinate DH?

A

ADP, Pi, Succinate

23
Q

What inhibits succinate DH?

A

OAA

24
Q

What produces NADH in the TCA?

A

produced from:
Isocitrate DH
Alpha-KG DH
Malate DH

25
Q

What produces GTP in the TCA?

A

Succinate DH

26
Q

What produces FADH2 in the TCA?

A

Succinate DH

27
Q

What produces CO2 in the TCA?

A

Isocitrate DH

Alpha-KG DH

FTM Biochem (3 decks)

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