PD vs HD - Motor

Question 1

Many hyperkinetic movement disorders can be caused by disturbances in the….

Answer 1

Basal ganglia

Question 2

What is the striatum?

Answer 2

The caudate nucleus and the putamen

Question 3

Where does the striatum receive most of its input from?

Answer 3

The glutamatergic fibres of the cerebral cortex

Specifically - motor cortex in frontal lobe (Brodmann 4 and 6)

Question 4

What are the two components of the striatum?

Answer 4

The patch and the extrastriosomal matrix

Question 5

In which disease does the striatum show damage/dysfunction?

Answer 5

HD
Cortico-basal degeneration
Multiple system atrophy
Wilsons disease

Question 6

Deep brain stimulation of the caudal intralaminar nuclei create symptoms of wat?

Answer 6

PD

Tourette’s syndrome

Question 7

Which other types of input does the striatum receive?

Answer 7

Dopaminergic from SN

Serotonergic from raphe nuclei

Question 8

How does input to the striatum differ in PD and HD?

Answer 8

HD - too much DA

PD - too little DA