PD mcq Flashcards
practice test
non motor PD symptoms
REM sleep behaviour disorder
anxiety
pain
motor symptoms of PD
tremor
bradykinesia
postural instability
drug side effects
dry mouth
dystonia
chorea
what does the 6-OHDA rat model least likely reflect
rapid DA neurons loss in SNc
what is true about mGlu4 receptors
present in glia and neurons
gi/go coupled
mGlu4 is group III
has an orthosteric and allosteric site
why choose PAM instead of a direct agonist
PAMs ensure mGlu4 activation only in regions where endogenous glutamate is release,
PAM requires glutamate to bind to orthosteric site
where does the glutamatergic pathway initiate
STN
why are animals tested twice
to obtain baseline score
what is tyrosine hydroxylase
rate-limiting enzyme in DA synthesis
why was there a lack of full inhibition with CPPG
not given a high enough dose
