PCP Expansion - Respiratory (Corticosteroids) Flashcards
What are glucocorticoids?
Glucocorticoids are hormones that mimic cortisol. They play a crucial role in stress response, regulation of metabolism, and anti-inflammatory and immunosuppressive effects
List three key roles of glucocorticoids
- Stress response
- Anti-inflammatory and immunosuppressive effects
- Metabolism regulation
How does glucocorticoids affect stress response?
Glucocorticoids suppresses non-essential functions and support the body during times of crisis, such as trauma or severe illness. They provide energy and suppress non-essential functions (e.g. digestive, immune and/or reproductive functions) to support the body during times of crisis
How does glucocorticoids affect anti-inflammatory and immunosuppressive effects?
Glucocorticoids can manage allergic reactions and inflammatory conditions by reducing the production of inflammatory substances
How does glucocorticoids affect metabolism regulation?
Glucocorticoids influence blood glucose levels by promoting the production of glucose and reducing its uptake by peripheral tissues. They also play a role in protein and lipid metabolism
Describe mineralcorticoids
Mineralocorticoids mimic the body’s primary mineralocorticoid aldosterone, which regulates sodium and water transport in the body
How do mineralcorticoids regulate electrolyte and fluid balance?
- Mineralcorticoids, particularly aldosterone, help regulate sodium and water levels in the body
- Mineralcorticoids enhance the reabsorption of sodium and water by the kidneys and promote the excretion of potassium
How do mineralcorticoids regulate blood pressure?
Mineralcorticoids indirectly regulate blood volume and pressure by controlling sodium and water balance in the body
What are two key roles of mineralcorticoids?
- Electrolyte and fluid balance
- Blood pressure regulation
When is Dexamethasone indicated?
Croup and bronchospasm secondary to asthma or COPD
What is the duration of Dexamethasone?
36-54 hours
What is the preferred route of Dexamethasone?
Oral administration is preferred for these indications
When is Hydrocortisone indicated?
Adrenal crisis
What is the duration of Hydrocortisone?
8-12 hours
What is the preferred route of Hydrocortisone?
IV administration is preferred for this indication
