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PBM > PBM Lecture Exam 1 > Flashcards

PBM Lecture Exam 1 Flashcards

1
Q

Reserpine

A

inhibit syn/storage of NE in sym n endings

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2
Q

Guanethidine

A

block release of NE from sym endings

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3
Q

Phentolamine

Phenoxybenzamine

A

block sym alpha receptors

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4
Q

Propranolol

Metoprolol

A

block sym beta receptors
propranolol (beta 1 and 2)
metoprolol (mainly beta 1)

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5
Q

Hexamethonium

A

sym activity blocked by inhibiting n transmission through autonomic ganglia
Works on nic-receptor
(Decreases reflex tachycardia if you drop BP)

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6
Q

Muscarine

Nicotine

A

direct-acting parasympathomimetic (cholinergic drugs)

bind directly to and activate receptors

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7
Q

Edrophonium

A

quaternary alcohol

  • -REVERSIBLY bind active site of AchE, prevent Ach access
  • -indirect-acting cholinomimetrics
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8
Q

Neostigmine

Physostigmine

A

carbamates

  • -REVERSIBLY bind AchE to form carbamoylated enz which is slowly hydrolyzed – more prolonged
  • -indirect acting cholinomimetics
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9
Q

Parathion

Malathion

A 
organophosphates
--undergo initial binding and hydrolysis by enz resulting in phosphorylated active site, phosphorous-enz complex 
extremely stable 
--IRREVERSIBLE -- very slowly hydrolyzed
--insecticides that can kill you
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10
Q

Sympathomimetic (adrenergic) drugs

A 
act on adrenergic effector organs
Examples:
Phenylephrine (alpha 1 receptor)
Isoproterenol (beta receptor)
Albuterol (beta 2 receptor)

Drugs w/ indirect sympathomimetic action: cause release of NE from storage vesicles in sym n endings –> NE causes sym effects
Examples:
ephedrine
amphetamin

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11
Q

Hyperkalemic periodic paralysis

A

mutation in Na+ channel
Met–>Val
Thr –> Met

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12
Q

Paramyotonia congenita

A 
mutation in Na+ channel
Leu --> Arg
Arg --> His or Cys
Gly-->Val
Thr--> Met
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13
Q

Modulators of VG Ca channels

A 
Dihydropyridines:
--nitrendipine (inhibitor)
--Bay K8644 (agonist)
Verapmil (phenylalkylamines)
Ditiazem (benzothiazepines)
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14
Q

Curare

A

Ach receptor agonist

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15
Q

Botulinum toxin

A

dec Ach release by n terminals

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16
Q

TTX

STX

A

block neuronal Na channel in presynaptic neuron

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17
Q

w-Conotoxin

A

Ca2+ channel blocker on presynaptic neuron

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18
Q

TTX
SSX
u-Conotoxin

A

blocks muscle Na+ channel at NMJ

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19
Q

TEA

A

Blocks K+ current

20
Q

TTX and STX

A

Blocks Na+

21
Q

Dendrotoxin

A

blocks K+ channel at presynaptic neuron

22
Q

Tetanus

Botulinum toxin

A

blocks Ach release from presynaptic neuron

23
Q

Physostigmine

DFP

A

block acetylcholinesterase

24
Q

Acetylcholine and nicotine

A

activate Ach Receptor

25
Q

d-Tubocurarine

alpha-Bungarotoxin

A

block Ach channel

nicotinic

26
Q

Agonists of nicotinic receptors

A

Ach
Carbylcholine
Succinylcholine
Nicotine

27
Q

Antagonists of nicotinic receptors

A

D-Tubocurarine

Pancuronium

28
Q

Atropine

Pirenzepine

A

inhibit M1, M3, M4 receptors

29
Q

Atropine

Methoctramine

A

inhibits M2, M4 receptors

30
Q

Phentolamine

A

blocks alpha 1 adrenergic receptors

31
Q

Yohimbine

A

blocks alpha-2 adrenergic receptors

32
Q

Metoprolol

A

blocks beta 1 adrenergic receptors

33
Q

Butoxamine

A

blocks beta-2 adrenergic receptors

34
Q

Disease caused by failure of heart as a pump

A

Congestive heart failure

35
Q

Disease caused by failure of blood as an effective liq organ

A

Thrombosis

Embolism

36
Q

Disease caused by failure of vasculature as a competent container

A

Hemorrhage

37
Q

Disease caused by failure of efficient distribution system

A

Atherosclerosis

38
Q

Nucleotide gated channels

A

cAMP

cGMP

39
Q

K+channels

A

Shaker
Shal
Shan
Shaw

40
Q

Brain Na+channels

A

Na I
Na II
Na III

41
Q

Ca2+ channels

A

Ca skeletal
Ca heart
Ca brain

42
Q

Nervous stimulation for copious sweating

A

Sym stimulation BUT

Cholinergic (Ach) – MUSCARINIC

43
Q

Atropine

Scopolamine

A 
belladonna alkaloids (plant-based)
muscarinic receptor antagonists
44
Q

Succinylcholine

Tubocurarine

A

Nicotinic receptor agonists

45
Q

Ipratropium

Tropicamide

A

synthetic agents

muscarinic receptor antagonists

46
Q

Hexamethonium

A

ganglionic blocker

nicotinic

PBM (5 decks)

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