PBL workshop (2nd)

Question 1

describe van der waals bonds

Answer 1

weak attractive force between molecules: electrons shift within molecule creating transient shifting charges

Question 2

describe hydrogen bonds

Answer 2

H+ on one molecule- electronegative region on other

Question 3

describe ionic bonds

Answer 3

between atoms of opposite charges

Question 4

describe covalent bonds

Answer 4

electrons shared between atoms

Question 5

what is the maximal response produced by the drug

Answer 5

efficacy

Question 6

what is the concentration at which the drug elicits 50% of its maximal response

Answer 6

potency

Question 7

what is the Bmax

Answer 7

number of receptor sites available to the drug for binding

Question 8

what is the propensity of a drug to bind to a receptor

Answer 8

affinity

Question 9

what is the drug’s ability to elicit response

Answer 9

intrinsic activity

Question 10

what does a noncompetitive antagonist do to the maximal response that the agonist can produce

Answer 10

reduces it

Question 11

what are quantal dose effect curves determined in

Answer 11

populations (not individuals)

Question 12

what is the median effective dose

Answer 12

the dose at which 50% of the individuals exhibit the specified quantal response

Question 13

what is the T.I. a relative indicator of

Answer 13

margin of safety of a drug

Question 14

what is the range of doses that are effective and safe

Answer 14

therapeutic window