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CRRAB Week 3 > PBL Drugs > Flashcards

PBL Drugs Flashcards

1
Q

What class is Nitro in?

A

Nitrate

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2
Q

What class is Furosemide in?

A

Loop Diuretics

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3
Q

What class does Enalapril belong to?

A

ACE Inhibitor

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4
Q

What class does Digoxin belong to?

A

Na+/K+ pump inhibitor

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5
Q

What class does Hydralazine belong to?

A

Nitrate

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6
Q

What class does Isosorbide dinitrate belong to?

A

Nitrate

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7
Q

What class does Metropolol belong to?

A

Beta1 Agonist

Inc. BP. Inc. HR & SV.

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8
Q

What class does Eplerenone belong to?

A

Mineralcoricoid Receptor Antagonist

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9
Q

What is the mechanism of Nitroglycerin?

A

Releases NO –> Inc. cyclic GMP in smooth muscle –> desphosphorylation of MLC –> Dilation of veins/arteries (more arteries) (1/2 life 1 to 4 minutes)

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10
Q

What is the mechanism of Furosemide?

A

Blocks NaCL (NKCC) reabsorption in thick ascending limb of loop of Henle

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11
Q

What is the mechanism of Enalapril/Lisinopril?

A

Competitive inhibitor of ACE (angiotensin-converting enzyme) prevents conversion of angiotensin I to angiotensin II –> Dec. Angiotensin II –> Inc. renin & Dec. aldosterone secretion

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12
Q

What is the mechanism of Digoxin?

A

Inhibits Na+/K+ ATPase pump in myocardial cells –> transient Na+ Inc. (intracellular) –> Ca2+ influx via Na+/Ca2+ exchange pump –> Inc. contractility

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13
Q

What is the mechanism of Hydrazine?

A

Release of NO from drug & endothelial cells –> arteriole dilation (not venous) (not well understood), Inc. CO & SV, direct relaxation of vascular smooth muscle, Dec. Diastolic more than systolic
*Only give with HTN

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14
Q

What is the mechanism of Isosorbide dinitrate?

A

NO –> Inc. cyclic GMP in smooth muscle –> Dephosphorylation of MLC –> Dilation of veins/arterioles (1/2 life 1+ hours)

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15
Q

What is the mechanism of metropolol?

A

Beta1 agonist, HR inc., SV inc., BP inc.

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16
Q

What is the mechanism of Eplerenone?

A

Selectively blocks mineralocorticoid receptors (in kidney, heart, blood vessels, brain) –> Dec. BP in dose-dependent manner [note: aldosterone is a mineralcorticoid]

CRRAB Week 3 (12 decks)

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