PBL 8

Question 1

where is the majority of serotonin produced?

Answer 1

raphe nuclei

Question 2

Where is the majority of Ach produced

Answer 2

pons

Question 3

Enzymes that destroy dopamine

Answer 3

MAO and COMT

Question 4

enzyme that converts tyrosine to DOPA

Answer 4

tyrosine hydroxylase

Question 5

enzyme that converts DOPA to dopamine

Answer 5

DOPA decarboxylase

Question 6

Neuro diseases with alpha synuclein

Answer 6

Parkinsons - selective loss of dopaminergic neurons in substantia nigra
Lewy Body dementia

Both involve misfoldings of alpha synuclein which results in aggregation and neuronal damage