PBL 4 Flashcards

1
Q

MILD bilateral gynaecomastia

A

benign enlargement of male breast tissue, on both sides

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2
Q

Undescending right testicle

A

a testicle which hasn’t moved into the scrotum

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3
Q

Variegated consistency

A

 having streaks, marks, or patches of different colours

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4
Q

organomegaly

A

abnormal enlargement of organs

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5
Q

Homogenous intratesticular mass

A

a mass in the testicles which exhibits essentially the same physical properties at every point throughout the mass

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6
Q

Low echogenicity

A

unable to bounce an echo very well; i.e. a dense mass in an USS

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7
Q

retroperitoneal lymph node dissection

A

removal of the retroperitoneal lymph nodes

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8
Q

Non-seminomatous germ cell tumour

A

one of the main groups of germ cell tumours

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9
Q

what are the testicular cancer statistics

A

The most common cancer in men aged 25-49
Median age of diagnosis: 33
2,300 men diagnosed in 2015 in the UK
Testicular cancer is rare in non-caucasians
Incidence of testicular cancer has more than doubled from the mid-1970s
Survival rates are now >95%

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10
Q

incidence rates of testicular cancer in different ethnicity of men

A
White: 6.6 per 100,000
Hispanic: 4.8 per 100,000
Native American: 4.5 per 100,000
Asian/Pacific Islander: 1.9 per 100,000
African American: 1.4 per 100,000
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11
Q

risk factors of testicular cancer

A

Baby boys who are born with undescended testicles

  • This accounts for ~3-5% of boys born
  • They have a 4-10 times higher risk of developing testicular cancer

Baby boys born with an indirect inguinal hernia

  • Inguinal hernias are when abdominal cavity contents enter the inguinal canal
  • They are the most common type of hernia
  • two main types: direct or indirect

Family history of testicular cancer

Using marijuana

  • 70% higher risk of developing testicular cancer
  • Linked to more aggressive forms of the cancer

Smoking
- Twice as likely to develop testicular cancer if you have a 12 year history of smoking

Height

  • Men who are 190-194 cm (6’ 2” – 6’ 4”) tall are twice as likely to develop testicular cancer
  • Men who are above 194 cm are thrice as likely to develop testicular cancer
  • Men who are less than 170 cm (5’ 6”) have a 20% decreased chance of developing testicular cancer

Predispositionary genes and environmental factors
- These will have a joint effect on key signalling pathways in the body
- This causes impaired differentiation of primordial germ cells
Primordial germ cells which are common origins of spermatozoa and oocytes
- So the spermatozoa and oocytes cannot be formed

The genes which maintain the germ cell niche do not get deactivated

  • This leads to the development of testicular germ cell tumours
  • Since there is an ideal environment, the germ cells continue to grow indefinitely
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12
Q

what are the signs and symptoms of testicular cancer

A

Firm, often painless mass/lump on the testicle

  • 25-50% of lumps cause some pain
  • Growth or swelling of the testicle
  • Abnormality in shape or consistency of one testicle when compared to the other
  • Associated abdominal pain that occurs with the above symptoms
  • 10% of cases are asymptomatic
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13
Q

what is the function of the testicles

A
  • production of spermatozoa

- production of the sex hormone testosterone

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14
Q

what are spermatozoa

A

The male gamete
Gametes are haploid cells which carry one copy of each chromosome
These are reproductive cells produced through meiosis
It is the mature motile male sex cell

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15
Q

what do spermatozoa do

A

fertilises the ovum

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16
Q

what does testosterone do

A

Stimulates the accessory male sexual organs

Causes the development of the masculine extra-genital sex characteristics

17
Q

describe the anatomy of the testicle

A
  • There are two testicles
  • They are covered by a sac of skin called the scrotum
  • This hangs below the penis, between the legs
  • Each testicle is covered by a tough, fibrous layer called the tunica
  • This is further subdivided into the tunica vaginalis (outer) and tunica albuginea (inner) layers
  • The testicle is divided into parts called lobules
  • Each lobule will contain tubes called seminiferous tubules where spermatozoa are produced
  • These seminiferous tubules open up into a series of uncoiled, interconnected channels called the rete testis
  • Ducts connect the rete testis to a tightly coiled tube called the epididymis (this is where sperm is stored)
  • This further joins to the long, large duct called the vas (ductus) deferens
  • Each testicle is held inside the scrotum by the spermatic cord
  • Each spermatic cord is made of tough CT and muscle
  • They will contain the vas deferens, blood vessels, lymph vessels, and nerves
18
Q

describe the lymph fluid draining from the testicles

A
  • Lymph fluid travels through vessels in the spermatic cord and drains from the testicles into several groups of lymph nodes at the back of the abdomen
  • These lymph nodes are called the retroperitoneal lymph nodes
19
Q

Describe the tunica albuginea

A

The tunica albuginea is the inner part of the fibrous capsule (tunica) which surrounds the testes
It will penetrate each of the testicles and forms the connective tissue which separates the lobules

20
Q

what do bloods tests show in testicular cancer

A
  • tumour markers are found in the blood of men with germ cell tumours,
  • Doctors may test these levels in order to check the progress of/presence of cancer
  • differentiate between seminoma and non-seminoma cancers
  • High levels of αFP, ßHCG, and LDH are all blood markers for germ cell cancers
21
Q

What are the non seminoma types of tumours

A

Embryonal carcinoma
Choriocarcinoma
Yolk sac carcinoma
Teratoma

22
Q

How do you use ultrasound for diagnosis

A

You lie on your back and a clear gel is placed on the scrotum, following which an ultrasound probe is used to image it
This helps to determine if the lumps are solid or fluid filled, and also if they are inside or outside of the testicle

23
Q

What is histogenesis

A

the differentiation of cells into specialised tissues and organs during growth

24
Q

describe how testicular cancer develops

A
  • Usually, the oncotic mutations accumulate before the rapid growth period of puberty
  • TGCT derives from abnormally arrested fetal gonocytes
  • Gonocytes are the earliest undifferentiated sex cell, and are initially not in the gonads
  • At birth, gonocytes will reside within the centre of seminiferous cords, and are in a state of mitotic arrest
  • Following birth, the gonocytes need to differentiate and undergo spermatogenesis to form spermatozoa
  • This occurs in the basement membrane of the seminiferous tubules during puberty
  • Spermatozoa are then stored in the epididymis
    TGCT is a histological heterogenous disease
  • This means that there are many possible causes
  • The high level of this heterogenicity is because gonocytes are highly pluripotent (capable of differentiating into various different types of cells
  • As the gonocytes have been arrested abnormally, at puberty these gonocytes do NOT form proper spermatogonia
  • These arrested gonocytes will accumulate genetic adaptations and mutations throughout childhood and before the onset of puberty
  • This becomes germ cell neoplasia in situ (GCNIS) in childhood and young adulthood
  • Finally, this emerges as invasive TGCT in the young adult
25
Q

describe staging of testicular cancer

A

Stage I: Contained in the testicle
Stage II: Lymph node spread, but no distant metastases yet
Stage III: Spread to lymph nodes in the thorax
Stage VI: Spread another organ e.g. the lungs

26
Q

describe lymph node drainage in testicular cancer

A
  • Lymph node drainage is always a fear with cancer
  • Drainage of the testes goes to the para-aortic lymph nodes
  • Lymphatic drainage of the scrotum goes to the superficial inguinal lymph nodes
  • These are retroperitoneal lymph nodes (i.e. abdominal lymph nodes)
  • Seminomas will metastasise through the lymphatics
  • They go into the retroperitoneal lymph nodes which are located anterior to T11 to L4 vertebral bodies
27
Q

How do you treat testicualr cancer

A
  • radical orchiectomies and retroperitoneal lymph node dissections are important
  • surveillance
  • seminomas are sensitive to radiation and chemotherapies
  • non seminimoas are not sensitive to radiation
28
Q

How do you self examine

A

Examine yourself once a month, preferably after a bath or shower
Know your normal, and any deviation is worth seeing your GP about

  • check one testicle at a time
  • hold testicle between thumb and fingers of both hands and roll it gently between the fingers
  • if you notice hard lumps, smooth or rounded bumps and changes in size, shape or consistency then see a GP
29
Q

what are checkpoints in the cell cycle

A

G1-S (1/2 mark) transition that the cell organelles have been replicated and that the cell has enough organelles to divide. (1/2 mark)
G2-M (1/2 mark) transition that the DNA has been replicated appropriately and accurately. (1/2 mark)
Exit M (1/2 mark) phase transition that the chromosomes have attached to the mitotic spindle. (1/2 mark)

30
Q

3 things for informed consent to happen

A
  • The patient must have capacity (Competence).
  • The patient must be offered adequate information (Adequate Disclosure).
  • The patient’s decision must be non-coerced/voluntary (Non-Coercion/Voluntariness)