PBL 4 Flashcards
MILD bilateral gynaecomastia
benign enlargement of male breast tissue, on both sides
Undescending right testicle
a testicle which hasn’t moved into the scrotum
Variegated consistency
having streaks, marks, or patches of different colours
organomegaly
abnormal enlargement of organs
Homogenous intratesticular mass
a mass in the testicles which exhibits essentially the same physical properties at every point throughout the mass
Low echogenicity
unable to bounce an echo very well; i.e. a dense mass in an USS
retroperitoneal lymph node dissection
removal of the retroperitoneal lymph nodes
Non-seminomatous germ cell tumour
one of the main groups of germ cell tumours
what are the testicular cancer statistics
The most common cancer in men aged 25-49
Median age of diagnosis: 33
2,300 men diagnosed in 2015 in the UK
Testicular cancer is rare in non-caucasians
Incidence of testicular cancer has more than doubled from the mid-1970s
Survival rates are now >95%
incidence rates of testicular cancer in different ethnicity of men
White: 6.6 per 100,000 Hispanic: 4.8 per 100,000 Native American: 4.5 per 100,000 Asian/Pacific Islander: 1.9 per 100,000 African American: 1.4 per 100,000
risk factors of testicular cancer
Baby boys who are born with undescended testicles
- This accounts for ~3-5% of boys born
- They have a 4-10 times higher risk of developing testicular cancer
Baby boys born with an indirect inguinal hernia
- Inguinal hernias are when abdominal cavity contents enter the inguinal canal
- They are the most common type of hernia
- two main types: direct or indirect
Family history of testicular cancer
Using marijuana
- 70% higher risk of developing testicular cancer
- Linked to more aggressive forms of the cancer
Smoking
- Twice as likely to develop testicular cancer if you have a 12 year history of smoking
Height
- Men who are 190-194 cm (6’ 2” – 6’ 4”) tall are twice as likely to develop testicular cancer
- Men who are above 194 cm are thrice as likely to develop testicular cancer
- Men who are less than 170 cm (5’ 6”) have a 20% decreased chance of developing testicular cancer
Predispositionary genes and environmental factors
- These will have a joint effect on key signalling pathways in the body
- This causes impaired differentiation of primordial germ cells
Primordial germ cells which are common origins of spermatozoa and oocytes
- So the spermatozoa and oocytes cannot be formed
The genes which maintain the germ cell niche do not get deactivated
- This leads to the development of testicular germ cell tumours
- Since there is an ideal environment, the germ cells continue to grow indefinitely
what are the signs and symptoms of testicular cancer
Firm, often painless mass/lump on the testicle
- 25-50% of lumps cause some pain
- Growth or swelling of the testicle
- Abnormality in shape or consistency of one testicle when compared to the other
- Associated abdominal pain that occurs with the above symptoms
- 10% of cases are asymptomatic
what is the function of the testicles
- production of spermatozoa
- production of the sex hormone testosterone
what are spermatozoa
The male gamete
Gametes are haploid cells which carry one copy of each chromosome
These are reproductive cells produced through meiosis
It is the mature motile male sex cell
what do spermatozoa do
fertilises the ovum