Pattern recognition Flashcards
What is pattern recognition?
The body detecting pathogens by looking for patterns and signs that show what pathogen they are
The recognition of pathogens
What patterns are recognised in pattern recognition?
Gram +ve and -ve
dsRNA: only present in viruses so if it is there it must from a virus
CpG motifs: bacterial DNA is unmethylated, so if it is present it must have come from bacteria
How does the body recognise patterns?
With pattern recognition receptors (PRRs)
What are PRRs?
Pattern recognition receptors
Where are PRRs found?
In the circulation: eg. C-reactive protein
Cell associated: on the cell membrane, or in the cytosol, eg. Toll-like receptors (TLRs) found on the csm
Membrane bound: eg. Mannose receptors on macrophages, these detect fungi
Intracellular: eg. Nod-like receptors (NLRs) & RLRs which detect dsRNA
Where is the PRR C-reactive protein found?
Found in the circulation
Where is the PRR Toll-like receptor found?
Cell associated, found on the cell membrane
Where are Mannose receptors found? And what do they detect?
Membrane bound
They detect fungi
Where are Nod-like receptors found? And what do they detect?
Intracellular
They detect dsRNA
