Pathways Flashcards

1
Q

What is the cGAS/STING pathway?

A
  • innate immune system signaling pathway
  • detects cytotoxic DNA (from tumorogenesis, viral infection or invasion from some intracellular bacteria)
  • cGAS binds DNA -> triggers GTP+ATP -> cyclic GMP-AMP (cGAMP) -> cGAMP then binds STING -> phosphorylation of IRF3 via TBK1
  • remember: IRF3 is transcription factor and phosphorylation means transcription of inflammatory genes
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q
A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly