Pathophysiology of Thromboembolism

Question 1

Binding promotes conformational change in platelet receptor glycoprotein IIb/IIIa (alpha IIIb beta epsilon)

step 1, 2, or 3 or platelet adhesion?

Answer 1

3

Question 2

Vessel injury exposes collagen and von Willebrand factor

Step 1, 2, or 3 of platelet adhesion?

Answer 2

1

Question 3

Platelet binds to exposed von Willebrand factor.

Step 1, 2, or 3 of platelet adhesion?

Answer 3

2

Question 4

Coagulation factor I common name?

Answer 4

fibrinogen

Question 5

coagulation factor II common name?

Answer 5

prothrombin

Question 6

coagulation factor IIa common name?

Answer 6

thrombin

Question 7

coagulation factor III common name?

Answer 7

tissue factor (TF)

Question 8

coagulation factor IV common name?

Answer 8

calcium

Question 9

coagulation factor III + VIIa common name?

Answer 9

extrinsic tenase

Question 10

coagulation factor Xa + Va common name?

Answer 10

prothrombinase complex

Question 11

coagulation factor VIIIa + IXa common name?

Answer 11

intrinsic tenase

Question 12

Cell based model:

Tissue factor (TF)/VIIa complex (extrinsic tenase) activates factors IX and X

Step 1, 2, 3, or 4 of initiation?

Answer 12

1

Question 13

Cell based model:

Factor Xa associates with factor Va to form prothrombinase complex

Step 1, 2, 3, or 4 of initiation?

Answer 13

2

Question 14

Cell based model:

Prothrombinase complex cleaves factor II (prothrombin) to factor IIa (thrombin)

Step 1, 2, 3, or 4 of initiation?

Answer 14

3

Question 15

Cell based model:

Initiation terminated by tissue factor pathway inhibitor (TFPI)

Step 1, 2, 3, or 4 of initiation?

Answer 15

4

Question 16

Cell based model:

Factor IIa (thrombin) activates platelet-bound factor XI and factors V and VIII

Part of initiation, amplification or propagation?

Answer 16

amplification

Question 17

Cell based model:

Factors V and VIII bind to platelet surfaces

Part of initiation, amplification, or propagation?

Answer 17

amplification

Question 18

Thrombin activates what coagulation factor?

Answer 18

XIII

allows fibrin strands to bond to one another

propagation

Question 19

Platelet bound factor XIa activates what coagulation factor?

Answer 19

IX

propagation

Question 20

VIIIa/IXa (intrinsic tease) promotes formation of what coagulation factor?

Answer 20

Xa

propagation

Question 21

In propagation, factor Xa associates with factor Va to form what?

Answer 21

prothrombinase complex

Question 22

Prothrombinase complex cleaves what coagulation factor?

Answer 22

II into IIa

propagation

Question 23

Thrombin converts fibrinogen to what?

Answer 23

fibrin

propagation

Question 24

In amplification, factor IIa (thrombin) activates what factors?

Answer 24

XI (platelet-bound factor)
V
VIII

Question 25

In amplification what factors bind to platelet surfaces?

Answer 25

V

VIII

Question 26

In initiation, tissue factor/VIIa complex (extrinsic tens) activates what factors?

Answer 26

IX

X

Question 27

In initiation, factor Xa associates with what factor to form the prothrombinase complex?

Answer 27

Va

Question 28

Initiation is terminated by what?

Answer 28

tissue factor pathway inhibitor (TFPI)

Question 29

Primary clot composition of arterial thrombi?

Answer 29

platelet

Question 30

Primary clot composition of venous thrombi?

Answer 30

fibrin

Question 31

Typical etiology of arterial thrombi?

Answer 31

atherosclerotic plaques

Question 32

Typical etiology of venous thrombi?

Answer 32

Virchow’s triad

blood stasis
hypercoagulable state
vascular injury

Question 33

Altered clotting factors is what in what part of Virchow’s triad?

Answer 33

hypercoagulable state