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GI/Rheumatology Module > Pathophysiology of SLE > Flashcards

Pathophysiology of SLE Flashcards

1
Q

Definition of SLE?

A

A multisystem chronic autoimmune disease characterized by abnormal autoantibody production.

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2
Q

What are the mechanisms of tissue injury in SLE?

A
  1. Immune complexes
  2. Complement fixation
  3. Deposition of antibodies/complement
  4. Inflammation
  5. Tissue damage
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3
Q

What are the vascular diseases in SLE?

A
  1. Vasculitis
  2. Thrombosis
  3. Atherosclerosis
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4
Q

What are the 2 common presenting symptoms of SLE?

A
  1. Polyarthritis
  2. Dermatitis
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5
Q

What are constitutional symptoms seen at onset of disease or during flare-ups?

A
  1. Fatigue
  2. Fever
  3. Anorexia
  4. Weight loss
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6
Q

What are the Musculoskeletal features of SLE?

A
  1. Arthralgia
  2. Myalgia
  3. Arthritis
  4. Symmetrical polyarthritis
  5. Deformities, NOT erosion
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7
Q

What are the acute cutaneous features of SLE?

A
  1. Erythematous
  2. Photosensitive
  3. Malar Area
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8
Q

What are the subacute cutaneous features of SLE?

A
  1. Annular
  2. Psoriasis-like
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9
Q

What are the chronic cutaneous features of SLE?

A

Discoid

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10
Q

What is SLE Serositis (inflammation) Pleurisy?

A

Presents as pleuritic pain, pleural rub, or pleural effusions

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11
Q

What is SLE Serositis (inflammation) Pleurisy concern?

A

Presents as pleuritic pain, pleural rub, or pleural effusions

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12
Q

What is SLE Serositis (inflammation) Pericarditis concern?

A

Symptomatic in 20-30% of patients

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13
Q

What are concerns of SLE and Pulmonary/Heart?

A
  1. Pneumonitis
  2. Pulmonary HTN
  3. Mycoarditis
  4. Endocarditis
  5. Dysrhythmias
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14
Q

What are the classes of Lupus Nephritis?

A

I: Minimal Mesangial
II: Mesangial Proliferative
III: Focal
IV: Diffuse
V: Membranous
VI: Advanced

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15
Q

What are the SLE Hematologic concerns?

A
  1. Anemia
  2. Leukopenia
  3. Thrombocytopenia
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16
Q

What is the Diffuse CNS Neuropyschiatric concern?

A
  1. Depression
  2. Seizures
  3. Dementia
  4. Migraines
17
Q

What is the Vascular CNS Neuropyschiatric concern?

A
  1. Strokes
  2. Vasculitis
  3. Ataxia
18
Q

What is the Peripheral Neuropyschiatric concerns?

A
  1. Peripheral neuropathy
  2. Mononeuritis multiplex
19
Q

What are the SLE GI problems?

A
  1. Abdominal Pain
  2. Hepatomegaly
  3. Occasional Pancreatitis
20
Q

What are the SLE Ocular problems?

A
  1. Cytoid Bodies
  2. Conjunctivitis
  3. Drug Induced Ocular Toxicities
21
Q

SLE Other problems

A
  1. Increased ESR
  2. Increased gamma globulins
  3. Decreased albumin
22
Q

What is the Hallmark test for SLE?

A

Positive ANA test
ANA Titer >1:80

23
Q

What happens to lymphocytes in SLE?

A
  1. Decrease total number of lymphocytes
  2. Increase B cell number or activity
  3. Decrease T-suppressor activity, increase T-helper

GI/Rheumatology Module (18 decks)

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