Pathophysiology of SLE Flashcards
Definition of SLE?
A multisystem chronic autoimmune disease characterized by abnormal autoantibody production.
What are the mechanisms of tissue injury in SLE?
- Immune complexes
- Complement fixation
- Deposition of antibodies/complement
- Inflammation
- Tissue damage
What are the vascular diseases in SLE?
- Vasculitis
- Thrombosis
- Atherosclerosis
What are the 2 common presenting symptoms of SLE?
- Polyarthritis
- Dermatitis
What are constitutional symptoms seen at onset of disease or during flare-ups?
- Fatigue
- Fever
- Anorexia
- Weight loss
What are the Musculoskeletal features of SLE?
- Arthralgia
- Myalgia
- Arthritis
- Symmetrical polyarthritis
- Deformities, NOT erosion
What are the acute cutaneous features of SLE?
- Erythematous
- Photosensitive
- Malar Area
What are the subacute cutaneous features of SLE?
- Annular
- Psoriasis-like
What are the chronic cutaneous features of SLE?
Discoid
What is SLE Serositis (inflammation) Pleurisy?
Presents as pleuritic pain, pleural rub, or pleural effusions
What is SLE Serositis (inflammation) Pleurisy concern?
Presents as pleuritic pain, pleural rub, or pleural effusions
What is SLE Serositis (inflammation) Pericarditis concern?
Symptomatic in 20-30% of patients
What are concerns of SLE and Pulmonary/Heart?
- Pneumonitis
- Pulmonary HTN
- Mycoarditis
- Endocarditis
- Dysrhythmias
What are the classes of Lupus Nephritis?
I: Minimal Mesangial
II: Mesangial Proliferative
III: Focal
IV: Diffuse
V: Membranous
VI: Advanced
What are the SLE Hematologic concerns?
- Anemia
- Leukopenia
- Thrombocytopenia
What is the Diffuse CNS Neuropyschiatric concern?
- Depression
- Seizures
- Dementia
- Migraines
What is the Vascular CNS Neuropyschiatric concern?
- Strokes
- Vasculitis
- Ataxia
What is the Peripheral Neuropyschiatric concerns?
- Peripheral neuropathy
- Mononeuritis multiplex
What are the SLE GI problems?
- Abdominal Pain
- Hepatomegaly
- Occasional Pancreatitis
What are the SLE Ocular problems?
- Cytoid Bodies
- Conjunctivitis
- Drug Induced Ocular Toxicities
SLE Other problems
- Increased ESR
- Increased gamma globulins
- Decreased albumin
What is the Hallmark test for SLE?
Positive ANA test
ANA Titer >1:80
What happens to lymphocytes in SLE?
- Decrease total number of lymphocytes
- Increase B cell number or activity
- Decrease T-suppressor activity, increase T-helper