Pathophysiology of ischaemic heart disease Flashcards
What are ischaemic heart diseases?
Group of clinicopathological syndromes due to imbalance of oxygen supply and oxygen demand
Oxygen supply depends on what factors
Coronary blood flow
Oxygen extraction & saturation
Oxygen demand depends on what factors
Cardiac contractility/rate
Ventricular wall tension (systolic/diastolic)
Oxygen requirement varies according to what
the rate and force of myocardial contraction
What is coronary arteries also known as? Why?
epicardial arteries
they flow on the superficial aspect of the heart
What is the epicardium?
the mesothelial lining of the heart
What does the left descending artery supply?
Supplies apex and anterior interventricular septum
What does the circumflex artery supply
supplies posterior left ventricle
What does the right coronany artery supply
Right ventricle and posterior aspect of the heart
What is coronary artery dominance
Tells you where the posterior descending branch is originating from
What are the types of coronary artery dominance? % of people with it
Right coronary artery dominance 70%
Co-dominant 20%
Left 10%
Why is coronary artery dominance important
The pos
The posterior descending branch perfuses the left inferior ventricular wall and part of the right inferior ventricular wall, the latter including the AV node
What is the most common cause of reduced flow in the coronary artery?
Atherosclerosis
