Pathophysiology Flashcards
1
Q
Massive Pulmonary Embolism
A
Defn: Hypotension or SBP drop of 40 mmHg or requiring inotropic support in the context of PE.
PA x-sectional area decreases less than 30-50% of PA bed which then stimulates release of pulmonary vasoconstrictor (serotonin and thromboxane.)
- Thromboxane causes pulmonary hypertension.
- Increased RV afterload, RV failure
- Increased RV pressure/dilation pushes septum into LV causing LV diastolic dysfunction
- Lack of perfusion causes V/Q mismatch
2
Q
Acute Kidney Injury Cause on ECMO
A
Organ hypoperfusion and exacerbation of previous chronic kidney disease are most common.
Inflammatory effluent from lungs and other organs
Hemoglobinuria
Microemboli and mechanical shear stress of blood
Dysregulation of RAAS/ANP system
