Pathophysiology

Question 1

What is Zollinger-Ellison syndrome?

Answer 1

Gastrin secreting pancreatic adenoma =? high gastric acid secretion which caused PUD

Question 2

What is helicobacter pylori?

Answer 2

Gram -ve bacteria that causes antral inflammation

• Antral D cells produce more somatostatin
• Antral G cells produce more gastrin => increased acid, which results in PUD

Question 3

What is pernicious anaemia?

Answer 3

Lack of red blood cells due lack of vitamin B12 absorption

This is caused because of a lack of parietal cells, leads to a lack of intrinsic factor, lack of vit-B12 absorption

(Also, no D cell stimulation => low somatostatin level => Hypergastrinaemia)