Common drugs in GORD/PUD Flashcards
What are the main receptors associated with a parietal cell?
Proton pump
H2 receptor
M3 receptor
CCK2 receptor
Prostaglandin receptor
List four protective substances in the stomach
Mucus
Bicarbonate
Prostaglandins
Mucosal blood flow
List four aggressive substances in the stomach
Acid
Pepsins
NSAIDs
H. pylori
What is the role of antacids?
To neutralise acid produced in the stomach
What is the role of alginates?
Increase viscosity of stomach content
Some form a “raft” to reduce symptoms of reflux
Give examples of antacids
Sodium Bicarbonate
Magnesium and Aluminium salts
Gaviscon
Rennie
Simeticone
Give an example of an alginate
Sodium alginate
What is the side effect of aluminium?
Constipation
What is the side of effect of magnesium?
Diarrhoea
What do alginates and antacids interact with?
Some antibiotics , i.e. coprofloxacin, tetracycline
Enteric coated preperations
What is the mechanism of action of sulcralfate?
Protect damaged mucosa by stimulating local production of prostaglandins and bicarbonate
What are the infications of sucralfate?
Treatment of peptic ulceration
Prophylaxis of stress ulceration
What are the side effects of sucralfate?
Constipation
What does sucralfate interact with?
Enteral feeds - “bezoar” formation
Digoxin, antibiotics, phenytoin - reduced absorption
What is the mechanism of action of misoprostol?
Prostaglandin analoge, i.e. prostaglandin receptor agonist
used in combination with NSAID, e.g. arthrotec