Pathophysiology Flashcards
A man diagnosed with hypertension has thickening of his left ventricle wall. This adaptive change of his left ventricle is best described as:
- Atrophy
- Hypertrophy
- Hyperplasia
- Metaplasia
-Hypertrophy
A cardiac panel helps in the diagnosis of a myocardial infarction and the timing and relative levels of various substances that make up the cardiac panel indicate the severity and duration of an MI.
- True
- False
-True
Although adaptation can help strengthen the heart initially to help overcome afterload, eventually if hypertension continues there may be an excess demand on the heart muscle to contract that cannot be met by the available blood supply, causing the heart to fail.
- True
- False
-True
Chest pain in Myocardial Infarction is caused by the build-up of the following substance that is formed under anaerobic respiration:
- Oxygen
- Lactic acid
- Glucose
- Carbon dioxide
-Lactic acid
Reperfusion injury involves which of the following processes:
- Host inflammatory responses
- Oxygen free radicals attack cellular lipids and proteins
- Damage to cell membranes that may release more free radicals
- Any of the above processes may occur during reperfusion injury
-Any of the above processes may occur during reperfusion injury
In myocardial infarction, blood samples contain a variety of substances that have leaked from dead and dying cardiomyocytes, including:
- Troponin 1
- CK-MB
- Myoglobin
- All of the above
-All of the above
Chronic ulcerative processes have been attributed to reperfusion injury as a consequence of alternating occlusion of blood flow then return of blood flow that sets off both inflammatory and oxidative stress responses that can cause tissue damage.
- True
- False
-True
Reperfusion injury is caused by the formation of:
- Reactive oxygen species
- Oxygen
- Lactic acid
- Calcium
-Reactive oxygen species
The most important change related to atherosclerosis that contributes to hypertension would be a(n):
- Decreased radius of the blood vessel
- Decreased viscosity of the blood
- Increased length of the blood vessel
- Increased radius of the blood vessel
-Decreased radius of the blood vessel
The heart undergoes which type of adaptation in response to hypertension:
- Atrophy
- Hypertrophy
- Hyperplasia
- Metaplasia
-Hypertrophy
Infection with Clostridium perfringens and the release of exotoxins is most likely associated with which type of gangrene?
- Dry gangrene
- Wet gangrene
- Gas gangrene
- Fournier’s gangrene
-Gas gangrene
Which of the following treatment approaches for gangrene is best described as the surgical removal of dead and dying tissue?
- Debridement
- Hyperbaric Oxygen Therapy
- Antibiotic Therapy
- Anticoagulants
-Debridement
The basic pathological process that underpins gangrene is a lack of oxygen usually due to ischemia.
- True
- False
-True
During the reproductive cycle in the female, hormonal stimulation increases the thickness of the endometrial lining of the uterus by increasing the number of epithelial cells. This is an example of the following type of adaptation:
- Atrophy
- Hypertrophy
- Hyperplasia
- Metaplasia
-Hyperplasia
During a myocardial infarction, cardiac monocytes are deprived of oxygen and acidosis results in protein denaturation and the cellular outline is preserved. This type of necrosis is best described as:
- Coagulative
- Liquefactive
- Caseous
- Fat
-Coagulative
During a focal bacterial infection, destruction of bacteria and immune cells results in the formation of pus. This type of necrosis is best described as:
- Coagulative necrosis
- Liquefactive necrosis
- Caseous necrosis
- Fat necrosis
-Liquefactive necrosis
During cell injury:
- Use of anaerobic metabolism increases lactic acid production, which can lead to cellular damage
- Reactive oxygen species are formed and interact with cellular proteins and lipids, causing cellular damage
- Compromise to membrane integrity can allow ions such as calcium to enter the cells, causing cellular damage
- Any of the above can occur during cell injury
-Any of the above can occur during cell injury
Cells can die by necrosis or apoptosis. Which of the following characteristics is associated with apoptosis BUT NOT necrosis?
- Autodigestion
- Inflammatory response
- Pyknosis
- Fragmented DNA
-Fragmented DNA
**This was listed as the correct answer, but I thought autodigestion was right based on our midterm
Hemosiderin is a golden brown pigment formed from phospholipids and proteins that is observed when cellular membranes degenerate.
- True
- False
-False
Normally, the body has anti-oxidant systems to deal with reactive oxygen species. These anti-oxidant systems include superoxide dismutase, which is an enzyme that converts hydrogen peroxide into water.
- True
- False
-False
Although cellular injury is often reversible, the one characteristic that distinguishes reversible and irreversible cell injury is that irreversible injury is marked by the influx of calcium, which signals cell death.
- True
- False
-True
Caseous necrosis involves the release of lipases, which digests fats and forms a soap-like substance as the fats combine with minerals such as calcium and magnesium.
- True
- False
-False
Which of the following types of hereditary or familial colon cancer are associated with mutations in DNA repair genes?
- FAP
- HNPCC
-HNPCC
Screening tests that measure the presence of blood in the stool include:
- Colonoscopy
- FOBT
- CEA
- All of the above
-FOBT