PATHOPHYS

Question 1

parkinson’s dz pathophys

Answer 1

decreased dopamine in substantia nigra; lewy bodies

Question 2

essential tremor pathophys

Answer 2

autosomal dominant
cerebellothalamocortical circuitry

Question 3

restless legs pathophys

Answer 3

iron deficiency
dopamine deficiency, thalamic issue, peripheral pathology?

Question 4

guillain-barre pathophys

Answer 4

Peripheral nerve demyelination
acquired autoimmune

Question 5

MS pathophys

Answer 5

CNS demyelination
idiopathic

Question 6

Bells Palsy pathophys

Answer 6

idiopathic
CN VII affected

Question 7

Myasthenia gravis pathophys

Answer 7

NMJ d/o
sensory & reflexes are ok!

Question 8

ALS pathophys

Answer 8

UMN + LMN necrosis = progressive motor degeneration
asymmetric progressive weakness starting in one limb

Question 9

Huntington’s pathophys

Answer 9

chromosome 4; CAG
autosomal dominant
degenerative changes in caudate, putamen, globus pallidus, temporal, frontal lobes
decreased GABA & acetylcholine levels

Question 10

Duchenne muscular dystrophy pathophys

Answer 10

x-lined d/o in dystrophin causing no protein and progressive proximal leg weakness

Question 11

Becker Muscular dystrophy

Answer 11

like DMD but milder and not treated w/ steroids