Pathology of the Mouth and Oesophagus Flashcards
Describe leukoplakia
- White patches >5mm in diameter - cannot be removed by rubbing or classified as any other diagnosable disease
- Undergoes malignant transformation
What sites can leukoplakia be found and how are they distributed?
- Anywhere in oral cavity e.g buccal mucosa, floor of mouth, ventral surface of tongue, palate
- Found individually or collectively with other plaques
Describe the appearance of leukoplakia.
- White patches or plaques with sharply defined borders
- Surface may be smooth or wrinkled
Describe oral candidiasis
Describe microscopic findings for leukoplakia.
- Surface stratified squamous epithelium
- Hyperkeratosis and acanthosis
- May show lesions with variable degree of dysplastic changes (including carcinoma in situ).
Describe erythroplakia.
- Greater risk of malignant transformation than leukoplakia
- Atypical epithelium
- Speckled leukoerythroplakia has characteristics of leukoplakia and erythroplakia
Describe appearance of erythroplakia.
- Red, velvety area within oral cavity
- Remains level with or slightly depressed in relation to surrounding mucosa
Why would a biopsy be done during leukoplakia and erythroplakia?
- Rule out dysplasia or carcinoma
What would subepithelial regions show in leukoplakia and erythroplakia?
- LEUKOPLAKIA - Inflammatory infiltrate of lymphocytes and macrophages - intensity proportional to degree of dysplasia
- ERYTHROPLAKIA - Vascular dilation and intense inflammatory reaction
Describe spread of oral cancer.
- Soft tissues of cheek, mandible or maxilla and perineural spaces
- Rare - regional lymph node metastasis
- Unreported - distant metastasis
Describe gross appearance and microscopy of oral cancer.
- GROSS - Large, fungating, soft papillary growth
- MICROSCOPY - Evidence of hyperkeratosis, acanthosis and papillomatosis on surface epithelium. Swollen rete pegs extending into deeper tissue
Describe oral cancer pathogenesis.
- Inactivation of p16 gene - leading to hyperplasia/hyperkeratosis
- Mutation of p53 gene - progression to dysplasia
- Overexpression of cyclin D1 gene - activates cell cycle progression
What are some risk factors for squamous cell carcinoma?
- Radiation exposure
- Welding, metal refining, diesel exhaust, wood stove, and asbestos exposure
- Chronic irritation of the mucosa - due to ill-fitting dentures, jagged teeth, or chronic infections
- Vitamin A deficiency and immunosuppression
- Poor nutrition.
Describe squamous cell carcinoma.
- Most common malignancy of the oral cavity
- Strong association with alcohol and smoking
- 30 % have regional lymph node metastases at presentation
- Overall 5-year survival ~ 50 % .
Describe microscopic appearance of squamous cell carcinoma.
- Infiltrative nests composed of squamous epithelium and intercellular bridges
- Keratin formation visible
What is general presentation of oesophageal diseases?
- Dysphagia
- Chest pain
- Regurgitation and heartburn
- Pain lasting minutes to hours radiating to back