Pathology- FC

Question 1

Through which vessels do WBC extravasate during inflammation?

Answer 1

Postcapillary venules

• due to thin-walled nature, postcapillary venules become more permeable during states of inflammation, allowing white blood cells to extravasate into the surrounding tissue.
• other vessels (like arteriole or capillariy) have too thick vessel wall

Question 2

Elevated troponin following percutaneous coronary intervention is due to what?

Answer 2

reperfusion injury

• percutaneous coronary intervention: stenting, performed to increase blood flow

Question 3

Cowden syndrome

• mutated gene? which chromosome?
• phenotype

Answer 3

• PTEN, chromosome 10q

- acral keratoses (papules on the hands and feet)

Question 4

Rb gene for retinoblastoma: what chromosome?

Answer 4

chromosome 13

• so does Wilson disease (ATP7B) and BRCA2 (male breast cancer)

Question 5

Is cardiac rhabdomyoma metastatic? If so what pathway? lymphatic or blood

Answer 5

Cardiac rhabdomyoma does NOT have metastatic potential. It is primary cardiac tumor LIMITED TO cardiomyocytes

Question 6

How is LDH level in transudate compared to serum level?

Answer 6

low (same as protein)

* nothing is high in transudate.

Question 7

In what chromosome is p16 tumor suppressor gene located

Answer 7

chromosome 9