Pathology exocrine pancreas Flashcards
Pancreatic Duct system
Duct of Wirsung: Main duct, at ampulla of Vater
Duct of Santorini: Accessory Duct at minor papilla
Pancreatic Divisum
- Path
- Prevalence
- Path: Pancreatic anlagen do not fuse creating two separate systems
- Prev: 3 to 10% iof population
Annular Pancreas
- Path
- Path: Ventral anlage remains fixed which create ring of pancreas around duodenum causing SBO
Heterotopic Pancreas
- Path
- Prev
- Portion of analge separated from bulk of pancreas or aberrant differentiation in other organs which results in pancreatic tissue detached from pancreas
- 2 -10 % pop
Pancreatic cancer Diag + Deaths
30,000 per year
Ductal Adenocarcinoma
- EPI
- Morph
- Epi: 85% all pancreatic cancer; AA older men who smoke
- Morph: Mucin-producing infiltrating glandular structures
Pancratic Cance rGenetics
- K-RAS Oncogene
- p53, p16, DPC4, BRCA2 TSGs
- DNA Mismatch repair genes MLH1; MSH2
Familial Pancreatic Cancer Types
- FAMMM Syndrome (p16)
- PJS (LKB1)
- Breast Cance rSyndrome (BRCA2)
- Hereditary Pancreatitis (trypsinogen)
- HNPCC (mimatch repair)
- Familial pancreatic cancer
Pancreatic Mucinous Cystic Neoplasms
- Morph
- Epi
- Mucinous cysts, ovarian stroma, NOT connected to main duct system
- Women ~ 50 YO
Pancreatic Intraductal Papillary Mucinous Neoplasms
- morph
- Epi
- Epi: Men/Women ~ 60 YO; <5% neoplasms
- Morph: “Mucin Oozing out of Ampulla of Vader;” Mucin cysts; NO ovarian stromal connected to native duct system
Serous cystadenomas
cystic, benign, von Hippel-Lindau syndrome
Acinar cell carcinomas
syndrome consisting of fat necrosis, eosinophilia, polyarthralgias, malignant
Pancreaticoblastoma
children, low-grade malignant
Pancreatitis causes
biliary tract disease/stones, alcohol, trauma, or hereditary pancreatitis.
