Hepatic Tests

Question 1

Test injury to hepatocytes

Answer 1

• Aminotranferases

- GGTs

Question 2

Test Liver’s capacity to transport anions/metabolized drugs

Answer 2

Bilirubin, BSL, ICG Clearance

Question 3

Tests that detect chronic inflammation, altered immune, or viral hepatitis

Answer 3

Igs, serologies, autoantibodiues

Question 4

Test Liver’s biosynthetic capacity

Answer 4

Albumin, Pt/INRm ferritin, ceruloplasmin, a-1-antitrypsin

Question 5

Test that suggests cholestasis

Answer 5

Alkaline phosphatase

Question 6

LFT

Answer 6

Bilirubin, Albumin, PT, ALP, AST/ALT,

Question 7

Which aminpotranferase is more specific for Liver pathology?

Answer 7

ALT

Question 8

AST Major Locations

minor location

Answer 8

• Liver
• Cardiac Muscle
• Skeletal Muscle
• minor: erythrocytes

Question 9

Which demographics Change ALT levels? How?

Answer 9

INC: Age, Male, BMI
DEC: Caffeine

Question 10

Medicationbs that affect ALT/AST

Answer 10

Erythromycin + Furosamide: DEC AST

Isoniazid: FALSELY DEC AST Only

Question 11

Alkaline phosphatase Reaction catalyzed/Function/Use

Answer 11

• Hydrolysis of organic esters
• Down-regulating secretory activities of intrahepatic biliary epithelium
• Detecting Cholestatic disease

Question 12

Causes of Alkaline Phosphatase elevation

Answer 12

“PROBably in Party Van D”

Paget's
Ricket's/Osteomalacia
Osteitis Fibrosa Cystica
Bony Tumors
Parathyroid Disease
Vitamin D Def

Question 13

Test used for Liver function NOT affected by Bone or Pregnancy?

Answer 13

GGT

Question 14

Causes of Elevated GGT

Answer 14

“Gary George Tillman, A Man People Mention Regardless of Culture or Demographics”

• Alcohol
• MEdication (Phenytoin, barbs)
• Pancreas\
• MI
• Renal
• COPD
• DM

Question 15

5-Nucleotidase Use

Answer 15

• Confirm hepatobiliary pathology

- More specific than alkaline phosphatase

Question 16

LDH Use

Answer 16

• Hepatobiliary diseasse

- Ischemia

Question 17

Isocitrate DH Use

Answer 17

• Disseminated malignancy w/ NO liver disease

- - Can be elevated in Hepatobiliary Disorder

Question 18

Test Chronic vs acute liver disease

Answer 18

Chronic: DEC Albumin
Acute: INC PT/INR

Question 19

45-year-old female hospitalized with acute hepatic failure has a rapid decrease in serum AST and ALT levels accompanied by a rise in serum total bilirubin and prolongation of prothrombin time. What are her labs indicative of?

Answer 19

AST and ALT decreasing tell me that either the acute damage has ceased, or the liver is so badly damaged that mores aminotrasferases aren’t being released. Bilirubin and PT are increasing so the liver is not functioning;