Hepatic Tests Flashcards
Test injury to hepatocytes
- Aminotranferases
- GGTs
Test Liver’s capacity to transport anions/metabolized drugs
Bilirubin, BSL, ICG Clearance
Tests that detect chronic inflammation, altered immune, or viral hepatitis
Igs, serologies, autoantibodiues
Test Liver’s biosynthetic capacity
Albumin, Pt/INRm ferritin, ceruloplasmin, a-1-antitrypsin
Test that suggests cholestasis
Alkaline phosphatase
LFT
Bilirubin, Albumin, PT, ALP, AST/ALT,
Which aminpotranferase is more specific for Liver pathology?
ALT
AST Major Locations
minor location
- Liver
- Cardiac Muscle
- Skeletal Muscle
- minor: erythrocytes
Which demographics Change ALT levels? How?
INC: Age, Male, BMI
DEC: Caffeine
Medicationbs that affect ALT/AST
Erythromycin + Furosamide: DEC AST
Isoniazid: FALSELY DEC AST Only
Alkaline phosphatase Reaction catalyzed/Function/Use
- Hydrolysis of organic esters
- Down-regulating secretory activities of intrahepatic biliary epithelium
- Detecting Cholestatic disease
Causes of Alkaline Phosphatase elevation
“PROBably in Party Van D”
Paget's Ricket's/Osteomalacia Osteitis Fibrosa Cystica Bony Tumors Parathyroid Disease Vitamin D Def
Test used for Liver function NOT affected by Bone or Pregnancy?
GGT
Causes of Elevated GGT
“Gary George Tillman, A Man People Mention Regardless of Culture or Demographics”
- Alcohol
- MEdication (Phenytoin, barbs)
- Pancreas\
- MI
- Renal
- COPD
- DM
5-Nucleotidase Use
- Confirm hepatobiliary pathology
- More specific than alkaline phosphatase
LDH Use
- Hepatobiliary diseasse
- Ischemia
Isocitrate DH Use
- Disseminated malignancy w/ NO liver disease
- - Can be elevated in Hepatobiliary Disorder
Test Chronic vs acute liver disease
Chronic: DEC Albumin
Acute: INC PT/INR
45-year-old female hospitalized with acute hepatic failure has a rapid decrease in serum AST and ALT levels accompanied by a rise in serum total bilirubin and prolongation of prothrombin time. What are her labs indicative of?
AST and ALT decreasing tell me that either the acute damage has ceased, or the liver is so badly damaged that mores aminotrasferases aren’t being released. Bilirubin and PT are increasing so the liver is not functioning;
