Pathology and microbiology of respiratory disease 1, 2 and 3 Flashcards

1
Q

List some bacteria that are normally present in the URT

A
Step - alpha haemolytic and non-haem and beta
Pasteurella
Staphylococci
E.coli
Actinobacillus
Proteus
Bordatella
Pseudomonas
Neisseria
Lactobacillus
Clostridium
Bacillus
Mycoplasmas
Chlamydophila
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

T/F: all viruses that cause infections of the URT or LRT can predispose to bacterial infections

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Outline features of bacterial infections of the LRT

A

primary/secondary

pure/mixed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Are primary or secondary bacterial infections of the LRT more clinically important?

A

secondary infections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Outline bacteria that can cause respiratory disease in small animals

A
Bordatella
Pasteurella
(B-haem strep)
Actinomyces and Nocardia
Chlamydophila
(Mycoplasmas)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the 4 species of Bordatella?

A

B.bronchisceptica
B. pertussis (whooping cough)
B. parapertussis (humans, sheep)
B. avium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Describe B. bronchiseptica

A
Strict aerobe, 
Gram negative rod
No different serotypes
Slow growing
Normal URT inhabitant 
Exogenous or endogenous infection
--> tracheobronchitis (KC) and bronchopneumonia (following distemper)
2 vaccines - live avirulent IN
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Outline B. bronchiseptica in the cat

A

Resp. disease common (unclear bacteria involvement)
Serological evidence - early exposure in kittens
Cultured in 11% cats (not household)
Vaccine = NobivacBb

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Pathogenesis and pathology - B. bronchiseptica

A

Initial trauma –> viral infection
Adherence (tracheal cilia)
Proliferation (airway)
Toxins released –> irritation and coughing

PATHOLOGY: Epithelial necrosis, peribronchial inflammation and interstitial pneumonia, severe pneumonia due to secondary invaders (e.g. b-haem strep)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the B. bronchiseptica pathogenicity factors? 2

A

ADHERENCE TO RESP. CILIATED EPITHELIUM - FHA, fimbriae and OMP
TOXINS - leucocyte toxin, tracheal cytotoxin (inhibits DNA synthesis), dermonecrotic toxin (ADP-ribosylation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Properties - Pasteurella multocida

A
gram negative
rod
oxidase positive
no growth on MacConkey
strong catarrhal smell
Normal oral bacteria (dog and others)
Secondary infection - URT infections
Common after bite wounds
Capsular serotypes - A and D
Vaccines (inappropriate currently)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Pathology - Pasteurella multocida - cats/dogs

A

severe suppurative pneumonia and pleuritis (pyothorax/empyaema)
Cat bites and wounds
Often mixed infections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is another name for rabbit snuffles?

A

enzootic pasteurellosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Describe rabbit snuffles clinical signs

A

Pasteurella multocida/ennzootic pasteurellosis
chronic nasal discharge and sneezing, purulent material filling sinuses, multifocal pulmonary abscesses
sometimes fatal
colonisation - respT (URT), middle ear, genitalia, occasionally lungs (ciliotropic)
Enzootic amongst rabbit colonies
difficult to eradicate
easy transmitted to uninfected rabbits.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Control - rabbit snuffles

A

Bacterin vaccines - fail

Long-term AM therapy (enrofloxacin) - to control and eliminate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

T/F: rabbits don’t have neutrophils

A

True - they have heterophils instead.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Describe Actinomyces viscosus as a bacteria

A

Gram positive, filamentous, branching
aerobic growth
commensal - canine oral cavity
–> granulomatous thoracic infection (dogs)
localised granulomatous abscesses of skin (chronic and progressive)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Outline Nocardia asteroides

A

soil bacteria
gram ppositive rods
thin, short filaments
partially acid-fast (wax-like mycolic acid)
grow within and destroy macrophage
chronic, progressive, suppurative thoracic granulomas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Treatment - Nocardia asteroides

A

Resistant to penicillin and some other AMs

Prolonged use of TMPS, TCs, Ampicillin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Pathology - nocardiosis

A

Copious red-brown exudate in pleural cavity
May become chronic with adhesion formation
Exudate contains ‘sulphur granules’

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What are sulphur granules on the pleural surface typical of?

A

filamentous bacteria (very hard for ABs to reach these bacteria here).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Outline Chlamydophila felis as a bacteria

A

intracellular
gram-negative rods
no growth on laboratory media

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Clinical signs - Chlamydophila felis?

A

Conjunctivitis (cats, most commonly)

Progress to interstitial bronchopneumonia (rare, only really if immunosuppression present too)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Diagnosis - Chlamydophila felis?

A

PCR - increasingly commonly
ELISA - Ag
Kosters stain (modified ZN) or fluorescein-labelled Ab.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Prevention - Chlamydophila felis?

A

Fel-O-Vax 4 or 5

No disease in the dog.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

What causes canine nasal aspergillosis?

A

Aspergillus fumigatus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Diagnosis - canine nasal aspergellosis

A
Radiology
Endoscopy
Serology (ID presence of fungi)
Culture (ID species)
Microscopy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Pathology - nasal aspergellosis

A

nasal turbinates progressivley destroyed by chronic granulomatous (and eosinophilic) inflammation

yellow-green mycotic exudate in caudal nasal cavity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Pathology - nasal aspergellosis

A

numerous fungal hyphae (histopathological exam)

Special strains = Grocott (black hyphae) and PAS (stains LPS pink)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Which breeds are prone to nasal aspergellosis?

A
GSDs
Doliocephalics (long head)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Treatment - nasal aspergellosis

A

long course of antifungals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Bacteria causing respiratory disease in sheep and cattle -7

A
Mannheimia
Pasteurella
Histophilus
Mycobacterium
Mycoplasma
Actinomyces
Actinobacillus
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

What factors lead to complex respiratory infections?

A

crowding, viruses, bacteria, stress, poor ventilation etc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

What effects do viruses have on epithelial cells of the resp.T.?

A

cilia clumping
mucous pooling
eventual loss of cilia (increases secondary infection risk)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

Other names of bovine respiratory disease complex (BRDC)? 2

A

Enzootic pneumonia

‘Shipping Fever’

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

What viruses contribute to BRDC?

A

PI3
RSV
BHV/IBR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

What other pathogens are implicated in BRDC (other than PI3, RSV and BHV/IBR)? 3

A

Mycoplasma bovis

Followed by:
Pasteurella multocida
Mannheimia haemolytica

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

Outline IBR infection?

A

causes ‘red nose’
URT infections –> fibrinous laryngitis and tracheitis

Diagnosis - Pathology - intranuclear viral inclusions
Vaccines available (multiple pathogens)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

Bovine Respiratory Syncytial Virus (BRSV):
Family
Effect
Prevention

A
Family = Paramyxoviridae
Effect = URT infections, bronchitis and bronchiolitis. Cytopathic effect is syncytia formation due to fusion protein which is produced.
{revention = Vaccines available
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

PI3:
Family
Effect
Prevention

A
Family = Paramyxoviridae
Effect = URT infections
Prevention = vaccine (multivalent)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

T/F: in BRDC, if you prevent the viral infection, you will stop the bacterial infection.

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

What disease does Mannheimia haemolytica cause in cattle?

A

Epizootic (endemic) pneumonia in cattle
Shipping Fever
Bovine pneumonic pasteurellosis

SHEEP - pasteurelloosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

T/F: M. haemolytica is a normal commensal in the nasopharynx of ruminants.

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

Outline M.haemolytica bacterial properties

A

beta-haemolytic on sheep blood agar
growth (weak) on MacConkey
Oxidase positive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

What is the primary agent responsible for calf pneumonia (numbers and severity wise)?

A

Mannheimia haemolytica

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

How many biotypes of M.haemolytica are there?

A

2 - biotype A and T

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

What allows M.haemolytica serotype A1 to cause disease (i.e. Bovine pneumonic pasteurellosis)?

A

Predisposing injury

48
Q

Outline histopathological features of Mannheimia haemolytica/pneumonic pasteurellosis

A

Fibrinous fluid

Fibrin, influx of cells (neutrophils predominantly)

49
Q

Pathology - pneumonic pasteurellosis - cattle

A

80% cases involve M.haemolytica and P.multocida

  • Bronchopneumonia is fibrinous to necrotising (leukotoxin and LPS)
  • pleuritis frequent
  • implicated in meningitis, also polyarthritis (2-4 month old housed calves)
  • sporadic cases of peracute fatal mastitis in cows
50
Q

Pathology - M. haemolytica

A

Pasteurellosis (lambs <3 months old)
septicaemia, severe pleuritis and pericarditis

Sheep/goats - severe mastitis

51
Q

Vaccination - M. haemolytica

A

CATTLE - natural protection via Ab to leukotoxin and capsular polysaccharide. (Bacterins not effections, Leukotoxin not effective. Iron-restricted OMP in combination with leukotoxin may be better). Bovipast RSP (RSV, PI3 and M. haemolytica).

52
Q

What does Pasteurella trehalosii cause?

A

acute/peracute septicaemia, older lambs (5-12months)

53
Q

T/F: you normally vaccinate sheep against M.haemolytica and P.trehalosii

A

True

54
Q

Outline Histophilus somnii infection

A
Normal commensal (genitals, transiently in URT)
Causes peracute death (young calves): acute thromboembolic meningoencephalitis, pneumonia, myocarditis
55
Q

What are the 2 categories of mycobacteria

A

Pathogenic mycobacteria and atypical mycobacteria (environmental saprophytes)

56
Q

Features - mycobacterium

A

Strict aerobes, very slow growing
Resistant - drying and chemicals
Virulent spp fully resist intracellular killing

57
Q

Can bovine TB kill a cow?

A

Yes - chronic eventually fatal, pneumonia and wasting.

58
Q

What is an open case of TB?

A

continuous shedding into the environment from lesions excreting to the exterior (kidney, udder)

59
Q

Diagnosis - bTB

A

Comparative ID test (PPD)
New methods = gamma IFN stimulation test (take a blood sample, take lymphocytes and stimulate with PPD then see if yIFN is produced in response to PPD. Positive reaction indicates prior exposure)

60
Q

Pathology - bovine TB

A

granulomatous pneumonia and lymphadenitis. Nodules have characteristic caseating (‘cheesy’) cut surface.

61
Q

Why are dairy cattle most at risk of bTB?

A

intensive management

62
Q

Outline Mycoplasma infections

A

inhabit mucosal surfaces
acquire host Ag to evade IR
infection may depress performance (90%)
involved in BRDC

63
Q

Why aren’t Mycoplasmas susceptible to B-lactam ABs?

A

no cell wall

64
Q

What does Myocplasma bovis (i.e. not Mycobacterium bovis) cause?

A

Arthritis, mastitis (and pneumonia)
Resp.T. commensal
‘Cuffing’ pneumonia in calves

65
Q

Gross pathology - Mycoplasma bovis - ‘cuffing’ pneumonia in calves

A
  • Part of calf pneumonia complex
  • Progressive cranioventral consolidation (bronchiectasis)
  • On cut surface, exudate in the main airways of affected lobules with thickening of the surrounding CT.
66
Q

Microscopic features - Mycoplasma bovis - ‘cuffing’ pneumonia in calves

A
  • Lymphoid nodules and follicles around airways
  • Follicles may compress bronchial lumina
  • Mixed cellular exudate in airways
  • Partial alveolar collapse
  • Slight thickening of alveolar walls (lymphocytes)
  • NO TOXINS
67
Q

Define BALT

A

bronchiolar lymphoid tissue

68
Q

What causes contagious bovine pleuropneumonia (CBPP)?

A

Mycoplasma mycoides subspecies mycoides SC (notifiable)

69
Q

Significance of contagious bovine pleuropneumonia (CBPP)

A

Not so much in western world, otherwise mortality up to 50% in indigenous breeds, no specific age association, transmission (aerosol, close contact),
DIAGNOSIS - CFT

70
Q

Pathology - CBPP - 5

A
  • Fibrino-necrotic bronchopneumonia with fibrinous pleuritis
  • Dorsocaudal areas may be affected
  • Interstitial septa widened by fibrinous exudate and oedema
  • Necrotic areas may be encapsulated (sequestra)
  • lung involvement is usually UNILATERAL
71
Q

Which mycoplasmas can affect sheep and goats?

A

M. ovipneumoniae - pneumonia
M. capricolum - pneumonia
M. mycoides sbsp. capri - pneumonia

72
Q

List 3 respiratory viruses of sheep.

A

PI3 (occasionally causes lamb penumonia)
RSV
Adenoviruses (ovine and bovine)
Isolated from resp. disease sheep but roles not certain - may predispose M.haemolytica (part of enzootic pneumonia complex in sheep).

73
Q

Control - respiratory viruses of sheep

A

No vaccines licensed for PI3, RSV or adenoviruses in sheep.

74
Q

What fungi cause respiratory disease -cattle/sheep?

A

Aspergillus and Micropolysporum

75
Q

Which bacteria cause respiratory disease in horses? 4

A

Step. equi subsp. equi
Rhodococcus
Actinobacillus
Mycoplasmas

76
Q

Which viruses cause respiratory disease in horses? 3

A

Equine influenza virus

EHV - 1 and 4

77
Q

Describe Strep. equi as a bacteria

A
gram positive
obligate parasite of horses
Lancefield group C
1 M-protein type
strongly beta-haemolytic with mucoid colonies
HA capsule becomes matt
78
Q

How can Strep. equi be differentiated from other beta-haemolytic strep?

A

Biochemical tests - trehalose (neg), sorbitol (neg), salicin (pos)

79
Q

Does Strep. equi cause lymphadenitis?

A

Yes (a suppurative lymphadenitis) - enlarged, abscessed LNs in head and neck. Also GP empyaema (site of long-term carriage). These can rupture and cause formation of draining tracts to skin surface.

80
Q

Define empyaema

A

a collection of pus within a naturally existing anatomical cavity. DDx = abscess which is a collection of pus BUT in a newly-formed anatomical cavity

81
Q

How can Strangles be prevented in horses?

A

Strepguard vaccine - ineffective

Equilis StrepE - live modified strain, inject in MM, now removed from market

82
Q

T/F: Streptococcus pneumoniae is the main cause of respiratory disease in the training horse

A

False - Streptococcus pneumoniae is an occasional cause of respiratory disease in the training horse

83
Q

Features - Rhodococcus equi

A
Gram positive rod (despite name)
variably acid fast
Actinomycete group
Naturally in soil and GIT (horses)
Persists in manure for a long time
84
Q

Pathology - Rhodococcus equi - foals

A
  • Important cause of suppurative bronchopneumonia - foals 2-6 months old
  • Complex lipid cell wall - resists digestion
  • Foci of caseous necrosis (lungs)
  • Lesions often extensive before CS show
  • High mortality (40-80%)
  • Bronchial LNs may also contain caseating foci
  • Dissemination to other organs
  • Adult horses immune
85
Q

Why does Rhodococcus equi cause granulomatous lesions in the lung?

A

It is a facultative intracellular pathogen –> undeveloped CMI

86
Q

Which horses do Actinobacillus affect?

A

Adult thoroughbreds

87
Q
Outline EIV as a respiratory disease:
subtypes
infection
CS
Secondary infections
vaccines
A
  • Subtypes (H7N7 or H3N8)
  • URT infection, may spread to LRT and cause bronchitis and bronchiolitis
  • CS: cough, pyrexia, depression
  • Secondary infections: Strep, Staph, Klebsiella
  • Vaccines: required for UK competing horses, inactivated vaccines containing both subtypes but aren’t protective against all strains.
88
Q

Outline EHV as a respiratory disease:

Subtypes
Infection location
CS
Vaccines

A

EHV4 - main resp disease, rarely abortion
Also, EHV1 (resp disease, abortion, paresis), EHV5 (equine multinodular pulmonary fibrosis)
Infection - URT
CS: nasal discharge, cough, pyrexia
Vaccines: inactivated containing EHV1 and EHV4

89
Q

What causes equine GP mycosis

A

Aspergillus nidulans

90
Q

Why does equine GP mycosis cause severe nasal bleeding and dysphagia?

A

close associated to internal carotid artery

91
Q

Diagnosis - equine GP mycosis

A
***Endoscopy***
Radiology
Serology
Culture
Microscopy
92
Q

Treatment - equine GP mycosis - 3

A

Local antifungal delivery
Ligate carotid artery
Systemic azole antifungal

93
Q

List 4 bacteria causing respiratory disease in pigs

A

Bordatella/Pasteurella
Actinobacillus
Haemophilus
Mycoplasmas

94
Q

List 3 viruses causing respiratory disease in pigs

A

PRRSV
Swine infleunza
Porcine circovirus

95
Q

Aetiology - atrophic rhinitis - swine

A

Combination of early colonisation of NP with Bordatella bronchiseptica with a dermonecrotic toxin (damages osteoblasts –> turbinate atrophy) AND Pasteurella multocida (type A or D) producing the osteolytic toxin which stimulates osteoclasts –> turbinate bone resoption and atrophic rhinitis.

96
Q

Why is swine atrophic rhinitis uncommon?

A

Because it is effectively vaccinated against.

97
Q

What causes contagious pleuropneumonia in pigs?

A

Actinobacillus pleuropneumoniae

98
Q

Outline contagious swine pleuropneumonia

A

Acute or chronic fibrinohaemorrhagic pneumonia with pleurisy

  • intensive pig production
  • worldwide
  • high morbidity and mortality
  • initial cases severe - progresses to chronic with sporadic cases
  • subclinical carriers and recovered carriers (depends on degree of immunity)
99
Q

Pathology - contagious pleuropneumonia - pigs

A
  • Fibrinonecrotic bronchopneumonia with pleuritis (cranioventral but spreads rapidly)
  • Pleural adhesions form in chronic cases.
100
Q

Bacterial features of Actinobacillus pleuropneumoniae

A
NAD-dependent (growth on chocolate agar)
waxy, sticky colonies
delicate
gram negative
15 serotypes (UK serotypes are 8, 2 and 6)
101
Q

Pathogenicity factors - Actinobacillus pleuropneumoniae

A
Apx toxins (these are RTX proteins. Cytolytic and haemolytic--> massive cytokine release --> pulmonary inflammation, haemorrhage and oedema)
Capsule polysaccharide
Takes iron from porcine transferrin
102
Q

How can you protect against Actinobacillus pleuropneumoniae?

A
  • Porcillis APP - subunit, Europe

- Suvaxyn HPP - killed, UK, no longer marketed

103
Q

What disease does Actinobacillus suis cause?

A

Pleuropneumonia-like disease (mild) in high health-status animals

104
Q

What disease does Haemophilus parasuis cause?

A

Glasser’s disease - polyserositis

Fibrinos exudate in high health-status animals

105
Q

Define polyserositis

A

= inflammation of several serous membranes (e.g. pleura, pericardium and peritoneum) at the same time

106
Q

Pathology - Glasser’s disease/Haemophilys parasuis - pigs

A
  • suppurative bronchopneumonia
  • polyserositis
  • lesions may be present singly or in combination
  • mortality high in young animals
  • predisposing factors include stress
  • multi-systemic disease
107
Q

What causes enzootic pneumonia (EP) in the pig (esp. young growing pigs)?

A
Mycoplasma hyopneumoniae
80-90% pig herds
widespread
predisposition to other respiratory disease
aerosol transmission
108
Q

Pathology - enzootic pneumonia/EP/Mycoplasma hyopneumoniae in pigs

A
  • usually chronic, non-fatal disease unless secondary infection is present
  • seen commonly at slaughter
  • reduced growth rate and coughing
    GROSS = cranioventral consolidation and red/grey discolouration
    MICROSCOPY = similar to ‘cuffing pneumonia’ in calves = lymphoid nodules and follicles around airways, follicles may compress bronchial lumina, mixed cellular exudate in airways, partial alveolar collapse, slight thickening of alveolar walls with lymphocytes.
109
Q

Define lung consolidation

A

becomes more solid

110
Q

Diagnosis - M.hyopneumoniae

A

serological diagnosis by competition ELISA

111
Q

What other mycoplasmas can affect the pig?

A
  • M.hyosynoviae - arthritis

- M.hyorhinis - commonly found in RespT, cause of polyserositis and arthritis

112
Q

What causes PRRS?

A

the PRRS virus (Arteriviridae)

113
Q

Outline PRRS:
Effects
CS
Predisposes what

A

Effects- infects URT, systemic spread in macrophages
CS - frequently subclinical respiratory signs and interstitial pneumonia
Predisposes or enhances effects of infection with other viruses or bacteria (influenza, M. hyopneumoniae)
Part of PRDC

114
Q

Outline swine influenza

A

Subtypes (H1N1, H3N2 and H1N2)
CS - sudden outbreaks of resp. disease with barking cough and respiratory distress (naive herds)
Effects - bronchiolitis and pneumonia. If endemic in the herd, weaned pigs will develop CS as soon as MAb levels decline.
Primary pathogen but if endemic will contribute to PRDC.
No vaccines licensed in UK
Zoonotic risk

115
Q

Outline PCV2:
effects
vaccines

A
  • Effects: Immuno-suppressive. Predisposes pigs to other infections. Possible involvement in PRDC, PMWS and porcine dermatitis and nephropathy syndrome (PDNS). Overall this is referred to as PCAD = porcine circovirus associated disease.
  • 2 vaccines licensed in UK