pathology Flashcards
what is oesophageal reflux?
reflex of gastric acid into oesophageas
hiatus hernia?
part of stomach moves into thorax
why does oesophageal ulcer form from reflux?
acid tears away tissue lining and this ulcer can form and bleed!
stricture of the oesophagus leads to?
obstruction due to scar tissue
barrets oesophagus?
precancerous changes to oesophagus lining where it becomes more intestinal like
explain change of epithelium in barret’s oesophagus?
squamous epithelium to glandular epithelia
metaplasia?
transformation from one cell type to another
barrel’s oesophagus increases chances of what?
oesophageal cancer ADENOCARCINOMA
DYSPLASIA ?
abnormal development of cells lead to various conditions e.g. - cancer
ulceration if left unchecked leads to?
perforation - loss of continuity of wall - hole
3 types of gastritis?
autoimmune, bacterial, chemical
bacterial gastritis caused by?
helicobacter pylori
h.pylori in stomach lead to what?
peptic ulcers, gastritis, stomach cancer
bacterial gastritis and autoimmune gastritis does what to acid secretion
bacterial = increases acid secreted autoimmune= decreases acid secreted
chemical gastritis due to ?
NSAIDS
ALCOHOL
bile reflux from small I
PEPTIC ULCERS?
open sores on inner lining of stomach, duodenum, lower oesophagus - anywhere gastric acid can come in contact
adenocarcinoma?
in mucus glandular cells
transcoelomic spread?
spread of cancer within peritoneal cavity
hepatomegaly? suggests?
enlarged liver - suggest metastases
ascites?
accumulation of fluid in peritoneal cavity
liver failure is what?
inability of liver to perform function
complication of acute and chronic liver injury = final stage of many liver diseases
alcohol affect on liver explain and describe
fatty change - accumulation
hepatitis inflammation
liver cell death
liver failure and cirrhosis
viral hepatitis types
A, B,C,E
cirrohosis?
late stage scarring fibrosis of liver
what is jaundice?
increased circulating bilirubin
cholestasis ?
decrease in bile flow so accumulation of bile
portal hypertension?
increased pressure inside portal vein in liver due to lack of flow(blockage)
primary sclerosis cholangitis associated with what condition?
IBD
complication of cirrhosis of liver? 3
altered liver function
hepatoceullar carcinoma
portal hypertension
portal hypertension leads to?
splenomegaly and oesophageal varies that can bleed
what is cholangiocarcinoma?
bile duct cancer
cholelithiasis?
gallstones
what are gallstones?
small stones made up of cholesterol that form in GB
CHOLECYSTITIS?
inflammation of gall bladder
causes of common bile duct obstruction?4
gallstones
bile duct tumour
stricture (fibrosis)
external compression
common Bile duct obstruction lead to what?
jaundice
IBD includes?
ulcerative colitis and chrons disease
what gene mutation in association with CD?
NOD2
what is pathology of IBD?
exaggerated immune response
what is ulcerative colitis?
colon inflamed and has ulcers in the tract which can bleed and produce pus
pseudopolyps?
projecting masses of scar tissue that develop from tissue during healing phase in repeated cycle of ulceration
pancolitis?
UC over entire large intestine
fistula?
abnormal connection between areas
ischaemic enteritis?
arterial blood flow to small I is restricted which leads to infarction
what is radiation colitis?
injury inflammation to colon due to radiation -
dysplasia is either?
high or low grade
what is dysplasia?
abnormal development of cells in tissue/organs
an adenoma? presents as?
benign tumour of glandular cells in epithelium - as polyps
high grade dysplasia is ?
precursor to cancer
most common type of colorectal cancer?
adenocarcinoma
colorectal adenocarcinoma types/names?
right-sided(ascending) = exophytic/polypoid left-sided(descending/tranverse) = annular
angle of his?
angle between stomach and oesophagus
pain when swallowing called?
odynophagia
dysphasia?
difficulty swallowing
achalasia?
condition where LOS doesn’t relax properly and muscles in oesophageal wall are weak - PARALYSED
pH metro into oesophagus meaning?
pH probe into oesophagus - measure acid levels in stomach - diary and record changes in pH over time
manometry into oesophagus does what?
describes pressure waves in oesophagus and give food to swallow and see pressure changes monitored
achalasia caused by?
nerves in oesophagus damaged - myenteric plexus damaged -
what happens with food in achalasia?
collects up in oesophagus bc LOS won’t open
fundoplication?
full/partial wrap of stomach around bottom of oesophagus
examples of 2 PPIs?
omeprazole and lansoprazole
what carcinoma is barrets more associated with?
adenocarcinoma
eosinophilic oesophagitis? caused by?
chronic allergen mediated inflammation of oesophagus caused by build up of WBC in lining of oesophagus.
dyspepsia?
bad digestion - group of symptoms
vomiting, nausea, upper abdomen pain, heartburn,
red flag symptoms for endoscopy ?
anorexia loss of weight anaemia recent onset >55 yrs melaena/haematemisis - gi bleeding swallowing difficulty ALARMS
what is helicobacter pylori?
gram negative bacteria, spiral shaped that form ulcers in stomach and inflammation
where does helicobacter pylori reside?
surface mucous layer DOES NOT PENETRATE LAYERS
outcomes of HP infection?
asymptomatic
gastritis
ulcer
cancer
outcomes of HP infection depend on?
site host factors (smoker, genes) characteristics of bacteria
what antibody present if HP infection?
IgG
tests to investigate for HP infection?
UREA breath test stool antigen test CLO urease test biopsy endoscopy
NSAIDS such as?
ibuprofen, aspirin, steroids,
ranitidine?
H2 receptor antagonist - reduce acid in stomach
haematemesis?
vomit blood
treatment to eradicate HP?
triple therapy
clarithromycin
amoxicillin
PPI
gastric outlet obstruction?
due to?
inflamed, scarred stomach ulcer obstructs passage of food
obstruction due to-
inflammation
scar tissue
2 types of gallstones
each caused by what?
cholesterol stones - increase in cholestrol
pigment stones - increase in bile
or mixed
blockage of pancreatic duct leads to?
pancreatitis
obstructive jaundice painful due to?
gallstones in common BD
lithotripsy?
fragment gallstones
biliary atresia?
congenital -
infants where bile ducts outside and inside are scarred and blocked
choledochal cysts?
congenital - bile duct swells and bile backs up into liver
what tumours cause jaundice?
bile duct cancers
gallbladder cancer
pancreas head cancer