Pathology Flashcards
1
Q
genetic mutation of type V Collagen def wich enzime
A
Ehlers-Danlos procollagen peptidase (Cleavage of procollagen C- and N- chains)
2
Q
Adolescent athlete
Knee pain worsen with Extension
A
Osgood-Schlatter Disease
Avulsion TIBIAL TUBERCULE (jumping)
Secondary ossification center
3
Q
Paget disease of the Bone- Osteitis deformans
M-CSF & RANK-L – NFkB Osteoclast / mixed / osteoblast
Sx.
Rx
Tx
A
Sx: bone thickening and hearing loss
Rx: Osteosarcoma
Tx: bisphosphonates
4
Q
Gradual onset of symptoms Pleuritic Fever Arthralgias Erythematous rash
ask for…
A
Anti-double strand DNA antibodies
High Specificity
5
Q
high Osm - low ICF low ECF cause?
A
Diabetes Insipidus
high serum osmolarity
low urine osmolarity
6
Q
ANTICARDIOLIPIN…
LUPUS ANTICOAGULANT…
produce?
A
Antiphospholipid Syndrome
Anticardiolipin__ FALSE + VDRL/RPR
Lupus Anticoagulant__ kPTT prolonged (but)
HYPERCOAGULABILITY STATE #Thrombosis #Preganancy Loss-Abortion