Pathology Flashcards
What are the Prognostic factors in bone tumor staging, in order?
metastases, discontinuous tumor, grade, and size.
What are the Prognostic factors in soft tissue tumor staging, in order?
metastases, grade, size, and depth.
The most common site of metastases from bone and soft tissue sarcomas?
Lungs
Broadly treatment options for Ewings and Osteosarcoma?
Chemotherapy is commonly used with limb salvage surgery
Usual Soft tissue tumor treatment ?
surgery and XRT
name 2 soft tissue tumors in which chemotherapy is used?
synovial sarcoma and rhabdomysarcoma
generally how does chemotherapy work?
induces programmed cell death
Generally how does XRT
work?
induces DNA damage of targeted cells.
name 2 complications of XRT treatment?
late stress fractures
fibrosis
post irridation osteosarcoma
Radiation may be pre- or postoperative. Postoperative external beam irradiation yields …………… local control rates, with a …………………of postoperative wound complications but a ……………….incidence of
postoperative fibrosis.
Radiation may be pre- or postoperative. Postoperative external beam irradiation yields equal local control rates, with a lower rate of postoperative wound complications but a higher incidence of
postoperative fibrosis.
name 3 tumours that only wide local excision used ?
chondrosarcoma
adamantinoma, parosteal osteosarcoma, and chordoma.
name 3 lesiosn that are treated with intralesional resection/ curettage?
GCT, ABC, NOF, LCH, osteoblastoma, and chondroblastoma.
name 3 lesions in <5 yrs old?
rhabdomyosarcoma, osteofibrous dysplasia, leukemia
name 3 lesions <30 yrs?
metaphyseal fibrous defect (nonossifying fibroma), enchondroma, unicameral bone cyst, osteosarcoma, Ewing sarcoma, osteoid osteoma, chondroblastoma, fibrous
dysplasia, giant cell tumor
name 3 lesions >50?
metastatic bone disease, fibrosarcoma, malignant fibrous histiocytoma, myeloma, lymphoma, chondrosarcoma, Paget disease
classic lesions in Ant Tibia?
adamantinoma, osteofibrous dysplasia
classic lesions in Posterior cortex of distal femur:
parosteal osteosarcoma, periosteal desmoid
classic lesions in epiphysis:
giant cell tumor, chondroblastoma, osteomyelitis (Brodie abscess), clear cell chondrosarcoma (femoral head)
classic lesions in metaphysis
metaphyseal fibrous defect (nonossifying fibroma), aneurysmal bone cyst, giant cell tumor, osteosarcoma
classic lesions in diaphysis:
Ewing sarcoma, fibrous dysplasia, eosinophilic granuloma (histiocytosis), multiple myeloma, osteoid osteoma/
osteoblastoma, infection.
the principles of biopsy?
- Use longitudinal incisions and excise biopsy tracts if the lesion is malignant.
- Approach lesions through muscles wherever possible. However, avoid functionally important structures and neurovascular structures.
- Maintain meticulous hemostasis and—only in rare cases—use a small drain at the corner of the wound to prevent hematoma formation.
- Frozen-section analysis should be performed intraoperatively to ensure that adequate diagnostic tissue is obtained.
- Samples should be sent for bacteriologic analysis.
What are four surgical margins of tumor excision:
intralesional, marginal (through reactive zone), wide (including a cuff of normal tissue), and radical (entire tumor and its compartment, including
surrounding muscles, ligaments, and connective tissues).
RB +p53
Osteosarcoma: tumor suppressor genes Rb (retinoblastoma) and
Ewing Sarcoma
t(11;22); gene product is EWS-FLI1
Synovial Sarcoma
t(X;18); gene products are SYT-SSX1 and SYT-SSX2
Myxoid liposarcoma
t(12;16); gene product is FUS-CHOP
Alveolar rhabdomyosarcoma:
t(2;13); gene product is PAX3-FKHR
Fibrous dysplasia:
GNAS1-activating mutation of the GSα surface protein
On MRI, most soft tissue malignancies are well defined (..…………………….) and heterogeneous. Any large ( cm) soft tissue
mass deep to fascia should be
On MRI, most soft tissue malignancies are well defined (pseudocapsule) and heterogeneous. Any large (>5 cm) soft tissue
mass deep to fascia should be considered a sarcoma.
Soft tissue sarcomas are…………………. intensity on T1-weighted sequences and …………intensity on T2-weighted images.
Soft tissue sarcomas are low intensity on T1-weighted sequences and high intensity on T2-weighted images.
Metastatic workup includes
CT scan of the chest
For liposarcoma, a CT scan of the ……………………………………….. is required because of
synchronous …………..
……………liposarcoma.
For liposarcoma, a CT scan of the abdomen and pelvis is required because of
synchronous retroperitoneal liposarcoma.
………………of a soft tissue sarcoma is the most common error. Residual tumor may exist, and ………………… should be
performed.
Unplanned removal of a soft tissue sarcoma is the most common error. Residual tumor may exist, and repeat excision should be
performed.
The most common soft tissue sarcoma of the hand
epithelioid sarcoma
The most common soft tissue sarcoma of the foot
synovial sarcoma
The primary site of metastases from soft tissue sarcomas is
Lung
Lymphatic metastasis occurs in what % of cases?
5%
tumors with a predilection for lymph node metastases are
ESARC (epithelioid sarcoma, synovial sarcoma, angiosarcoma, rhabdomyosarcoma,
clear cell sarcoma) and are the most common.
Extraabdominal desmoid tumors are ………….. Patients with Gardner syndrome (familial adenomatous polyposis) have a …………….-fold increased risk for such tumors. ………………….. can be used for treatment. ………….surgical resection
is recommended, but …………………. common.
Extraabdominal desmoid tumors are “rock-hard.” Patients with Gardner syndrome (familial adenomatous polyposis) have a 10,000-fold increased risk for such tumors. Estrogen receptor β inhibitors can be used for treatment. Wide-margin surgical resection
is recommended, but local recurrence is common.
Nodular fasciitis is a painful rapidly enlarging mass in a person ….to …… years of age. Perform a resection with a ………. margin.
Nodular fasciitis is a painful rapidly enlarging mass in a person 15 to 35 years of age. Perform a resection with a marginal margin.
Undifferentiated pleomorphic sarcoma, previously known as ………………………………., is the most common malignant sarcoma of soft tissue in adults. It appears on MRI as a ………………………….mass that has a …….signal on T1-weighted images and a ………..signal on T2-weighted images. Treatment is with
……..-margin local excision and adjuvant ……………………………..
Undifferentiated pleomorphic sarcoma, previously known as malignant fibrous histiocytoma, is the most common malignant sarcoma of soft tissue in adults. It appears on MRI as a deep-seated inhomogeneous mass that has a low signal on T1-weighted images and a high signal on T2-weighted images. Treatment is with
wide-margin local excision and adjuvant radiotherapy.
Lipomas appear on MRI as well-demarcated lesions with the ………….signal characteristics as those of ……………..on all sequences. On ……………sequences, the lipoma has a uniformly …………..signal. Treatment of asymptomatic lesions is observation, whereas that for
expanding or symptomatic lesions is ……………excision.
Lipomas appear on MRI as well-demarcated lesions with the same signal characteristics as those of mature fat on all sequences. On fat-suppression sequences, the lipoma has a uniformly low signal. Treatment of asymptomatic lesions is observation, whereas that for
expanding or symptomatic lesions is marginal excision.
Myxoid liposarcoma has a classic…………………chromosomal translocation
Myxoid liposarcoma has a classic 12;16 chromosomal translocation
how do you identify Liposarcoma on MRI?
areas of the lesion supress with t2 fat suppression but other areas are bright on T2 fat suppression.