Pathology

Question 1

Rx for minimal change disease?

Answer 1

Steroids- Prednisolone

Question 2

Out of nephrotic and nephritic syndromes, which tends to be inflammatory (will be seen on immunofluorescence)?

Answer 2

Nephritic- Infective endocarditis, post-infectious, IgA, Goodpastures, Vasculitis

Question 3

Hepatitis B is associated with which glomerulonephritidies?

Answer 3

Membranous (can also be caused by gold, penicillamine- think RA or tumour)

Question 4

What type of nodules suggest a cause of diabetic focal segmental glomeruloscleritis, if seen under the microscope?

Answer 4

Kimmelsteil-Wilson nodules

Question 5

Membranous nephrotic syndrome will look like what under the microscope?

Answer 5

Membrane spikes

Question 6

What is the management of a patient with suspected IgA glomerulonephopathy (nephritic syndrome)?

Answer 6

No biopsy needed unless renal function is getting bad, just yearly BP, Creatinine etc

Question 7

What causes crescents on microscopy in glomerulonephridities and what is it’s significance?

Answer 7

Crescents indicate space filled in by inflammatory cells and later, if chronic fibrosis.
It is a poor prognostic sign and can be used to monitor if treatment is working,

Question 8

Focal segmental glomerular sclerosis is a pattern of injury seen under the microscope caused by which 2 conditions?

Answer 8

Diabetes

Amyloid