Pathology Flashcards
1
Q
Acute Mastitis:
- Caused by?
- Treatment?
- Can lead to what?
- Check that it isn’t what?
A
- Staph Aureus with breast feeding
- Continue feeding/ Dicloxacillin
- Abssess/ mass
- Inflammatory CA
2
Q
Periductal Mastitis:
- Bacterial?
- Inflammation of what? Can cause?
- Usually in who? Due to?
- What happens to the duct?
- Eventually leads to? (2)
A
- No
- Subaereloar ducts; nipple retraction
- Smokers; Low vitamin A
- Blocks with inflammation behind
- Fibrosis/ nipple retraction
3
Q
Mammary Duct Ectasia:
- Ectasia means?
- What happens in duct?
- Commonly in who?
- Discharge?
- Finding on histology?
A
- Dilation
- Inflammation/ dilation under areola
- Multperous/ post meno women
- Green/brown nipple discharge
- Chronic inflammation with plasma cells
4
Q
Fat Necrosis:
- Usually due to?
- On mammography?
- Histology?
A
- Trauma
- Mass with calcification
- Giant cell/ clacification
5
Q
Developmental: 1.) Accessory nipple where? 2.) Nipple retraction: 3.) Juvenile Hypertrophy is what? Gynecomastia: - In who? Uni/bi lateral? Due to? Occurs with? (4)
A
- ) Along the milk line
- ) Can happen
- ) Huge Ta’s
- Men; both; estrogen; drugs/Kline/Test. Tumor/Liver Dz
6
Q
Breast:
- 6 parts? Pathology of each?
- Guys don’t have what? pregnancy increases what?
A
- ) Stroma: Fibroadenoma/phyllodes
- ) Lobules: Lobular CA
- ) Term. Ducts: Tubular CA
- ) Major Duct: Fibrocystic change; DCIS; Invasive ductal CA
- ) Lactiferous duct: Intraductal pailloma; Absess; mastitis
- ) Nipple: Absess/ Paget
- Lobules; Acini
7
Q
Fibrocystic Change:
- Often in who?
- Appearance?
- Increased risk of CA?
- Can find what on biopsy?
A
- Premenopausal women
- Lumpy breats; blue domed appearance
- None!
- Other changes
8
Q
Fibrocystic Change Other findings:
- ) Fibrosis, cysts, apocrine metaplasia:
- Any combo of the three risk of cancer? - ) Ductal hyperplasia:
- Risk of invasive carcinoma? - ) Sclerosing Adenosis: Too many what in lobule?
- What b/n glands? Risk of invasive carcinoma? Calcified? - ) Atypical Hyperplasia: Atypical where? (2)
- Risk of invasive carcinoma? Applies to what?
A
- ) None
- ) 2x risk
- ) Glands; fibrosis; 2x risk; Calcified
- ) Atypical cells in duct or lobule; 5x risk; both breasts
9
Q
Intraductal Papilloma:
- Papillary growth into?
- Fibrovascular projection lined by?
- Bloody nipple?
- Must distinguish from?
- Common in who?
- No myoepi =?
A
- Large duct
- Epi and myoepi
- Yes
- Papillary carcinoma
- Premeno women
- More likely carcinoma
10
Q
Fibroadenoma:
- Benign tumor of? Risk of CA?
- Well circumscribed? Mobile? Marble like?
- Estrogen sensitive?
- Common in who?
A
- Fibrous tissue/gland; NONE
- Yes; yes; yes
- Yes
- Pre meno women
11
Q
Phyllodes Tumor:
- Fibroadenoma like tumor with increased what?
- Common in who?
- Malignant? Where? (2) What is malignant?
A
- Fibrous component
- Post meno women
- Can be malignant; lungs and bone; stromal component
12
Q
DCIS:
- Malignant prolif of cells where?
- Calcification?
- 2 types? 1 with bad prognosis?
- Pagets? Presents as what?
A
- In ducts
- YES!
- Comedo/cribrigorm; comedo
- DCIS up the duct; ulceration/erythema
13
Q
Invasive Ductal Carcinoma:
- Common?
- Dimpling?
- Biopsy shows what? (2)
1. ) Tubular Carcinoma: Makes what? Stroma? Myoepi? Prognosis?
2. ) Mucinous: Prognosis? Common in who? Assoc with?
3. ) Inflammatory: Looks like what? Blocks what? Prog?
4. ) Medullary: High grade? Lymphocytes? Assoc. with?
A
- More common than lobular
- Yes
- Duct like structures/ desmo stroma
1. ) Tubules; desmoplastic; none; good
2. ) good; elderly; BRCA 1
3. ) Mastitis; lymphatics; bad
4. ) Yes; many; BRCA1!!!!!!! Triple negative
14
Q
LCIS:
- Malignant prolif of?
- Mass/ calc?
- Cohesive cells?
- Multifocal/bilateral?
- Treatment? Removal?
- Increased risk to?
A
- Lobules
- No
- No E Cadherin
- often
- Tamoxifen; no
- Both breasts; unlike DCIS
15
Q
Invasive Lobular Carcinoma:
- Grows how?
- Duct formation?
- Lungs/ pleura? CSF/ GI/ Ovaries/ Uterus?
A
- Single file
- None; no E cadherin
- Less likely; more likely
