Pathology Flashcards
Drugs used in multiple myeloma
Bortezomib
Lenalidomide
Dexamithazone
‘Boring Ladies Die’
Ruxolitinib is a _______ and is used for the treatment of _______
JAK inhibitor
Polycythemia vera
Rituximab is a _______ and is used for the treatment of ______
MAB to CD 20
B cell non hodgkin lymphoma
Dabrafenib is a _______ and is used in the treatment of _____
BRAF inhibitor
Hairy cell leukemia
Pathogenesis of aneurysm in hypertension
In HTN–> Arteriosclerosis can cause narrowing of lumen of blood vessels as well as vasa vasorum–> necrosis of smooth muscles–> muscle wall strength is decreased
Asbestos bodies are made of
Iron + Calcium + Asbestos
Examples of 2 types of hypersensitivity taking place in same disease
- Hypersensitivity pneumonitis– type III, IV
- RA– type II, IV
- SLE– type II, III
- Atopic dermatitis– type I
What is mycoides fungoides?
Cutaneous peripheral T cell lymphoma
Diagnosis of Mycosis fungoides
Skin biopsy (positive for CD 3)
Bradykinin causes?
Increased vascular permeability (vasodilation), pain
Hereditary hemochromatosis gene mutation seen is?
HFE gene mutation
Manifestations of hereditary hemochromatosis?
Type I DM
Hyperpigmentation of skin
Atrophic testes
Dilted cardiomyopathy
Another name for hereditary hemochromatosis?
Bronze diabetes
Which color vacutainer for–
1. Direct Coomb’s test
2. Indirect Coomb’s test
- EDTA/ Lavender
- Red
What is being measured in Direct Coomb’s test?
Ab bound to RBC
In cystic fibrosis–
_____ sodium in sweat
_____ chloride in bronchial secretions
Nacl _____ in exocrine secretions
Nacl ______ in sweat
________ bicarbonates in pancreatic secretions
Increased/ Decreased?
- Increased
- Decreased
- decreased
- Increased
- Decreased
Child presenting with anemia, jaundice. On PS– schistocytes +
Diagnosis?
What other finding will be present?
HUS-TTP
Renal failure +
Russell’s viper venom MOA
It is thrombogenic– directly activates factor 10
Worst and best prognosis among breast carcinoma types
Ductal ca (it is MC as well as worst prognosis)
Best– Tubular type
Why does medullary Ca of breast have good prognosis?
- Pushing (not infiltrative) margins
- Lymphocytic infiltration +
Patient with multiple petechiae, purpura, abd cramps x 2 mths
Now, oliguria, pedal edema, BP 140/90, PR 88/m, Urine– RBC, RBC cast. Renal biopsy– crescent shape glomerular infiltration
IF- negative
Diagnosis?
Skin +
GIT +
A/c nephritis– (oliguria, pedal edema, RBC and RBC cast) which is progressing to a/c renal failure
Crescent on biopsy
IF negative (paucimmune GN)
Dx: Rapidly progressing glomerulonephritis (eg. Granulomatosis with polyangitis)
IF finding of:
1. Henoch Schnolein Purpura
2. Good pasteur syndrome
3. Lupus nephritis
- Granular deposits of IgA
- Linear deposits
- Granular deposits
Markers for melanoma
HMB45 (specific), S100 (non specific), MELAN A
Napsin A is a marker for
Adenoca
Cytokeratin is a marker for
All carcinomas
