Pathology Flashcards

1
Q

What hormonal compressive symptom can tumours in / around the pituitary cause?

A

Hypofunction - a deficiency of hormones produced in the adenohypophysis

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2
Q

What can tumours cause if they cause an excess of hormonal secretion?

A

Hyperfunction of the pituitary

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3
Q

What is a PitNET ?

A

Pituitary Neuroendocrine Tumour

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4
Q

Name the tumour classified as a TPIT lineage and what it produces?

What does this cause?

A

Corticotroph PitNET - ACTH

Cortisol excess

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5
Q

What can a corticotroph PitNET ultimately cause?

A

Cushing’s disease

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6
Q

What are SF 1 tumours known for?

A

Mass effects - visual disturbances, headaches, hypopituitarism

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7
Q

Name the 2 types of adrenal cortical origin?

A

Adrenal cortical adenoma
Adrenal cortical carcinoma

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8
Q

Unilateral / solitary, well-circumscribed, non-invasive nodule that can be functional OR non-functional describes what type of adrenal tumour?

A

Adrenal cortical adenoma

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9
Q

Unilateral / solitary, less well defined, invasive nodule that can be functional OR non-functional describes what type of adrenal tumour?

A

Adrenal cortical carcinoma

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10
Q

Name the most common neoplasm of the adrenal medulla?

A

Pheochromocytoma

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11
Q

What is a paraganglioma?

What are they very similar to?

A

A tumour arising from extra-adrenal tissue

Pheochromocytomas

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12
Q

What is a ‘Zellballen’ pattern often suggestive of?

A

Pheochromocytoma

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13
Q

Are pheochromocytomas malignant or benign?

A

Due to the nature of the tumours - patients with pheochromocytomas are considered to have lifelong risk of metastases and are conceptually considered ‘malignant’

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14
Q

What do pheochromocytomas arise from?

A

The adrenal medulla

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