Pathology Flashcards
1
Q
- What is a Gliomas?
- Come From? - How are Gliomas classified?
- What is Astrocytoma?
A
- Primary form of brain tumor.
- arise from glial cells
They can be further classified - by the cells from which they arise.
- Common derivative of gliomas
2
Q
- How do Astrocytoma appear on image?
- Why CT Brain done w/ contrast?
- What is an aneurysm?
- Common locations?
A
- Astrocytoma = areas of low attenuation, with displacement of the midline.
- to be able to delineate the tumor from the surrounding tissue.
- An aneurysm = localized dilation and weakening of an arterial wall.
- thoracic or abdominal aorta
3
Q
- What appears as areas of low attenuation, with displacement of the midline in CT Brain?
- What can be found in the medial layer and is associated with turbulent blood flow, from a bifurcation, or from an atheroma?
- What is localized dilation and weakening of an arterial wall.
A
- Astrocytoma
- Aneurysm
- Aneurysm
4
Q
- Aneurysm shape is based on?
- Aneurysm defect is found?
- Causes of Aneurysm:
A
- A. different shapes depending on how it develops
- in medial layer and is associated with turbulent blood flow, from a bifurcation, or from an atheroma
- Trauma, atherosclerosis, syphilis, congenital defects, and hypertension
5
Q
- Aortic aneurysms are typically imaged in what phase?
- Why? - Two types of strokes:
- Stoke Protocol is what type of CT?
A
- ARTERIAL PHASE
- Aneurysms occur in any artery - Ischemic & Hemmorrhagic
- CT brain without &/or CTA Head
6
Q
- Which strokes occur when a vessel in the brain ruptures and bleeds into the brain
- What is a condition that sometimes can be detected as palpable pulsating masses with bruits.
- Which stroke arise when a vessel in the brain develops a blood clot, and blood flow is reduced?
A
- Hemorrhagic
- Abdominal aneurysms
- Ishemic
7
Q
- How may Ischemic strokes be diagnosed?
- What is an Ischemic stroke?
- What can occur from Ischemic?
A
- use of CT Head without contrast and/or a CTA Head
- arise when a vessel in the brain develops a blood clot, and blood flow is reduced.
- If blood flow to brain is reduced for a long period of time, an area of infarction may develop.
8
Q
- When might an infarction develop?
- What is Hemorrhagic stroke?
- Symptoms of Hemorrhagic stroke?
A
- Blood flow to part of brain is reduced / stop
- ISCHEMIC STROKES - strokes occur when a vessel in the brain ruptures and bleeds into the brain
- usually rapid and are preceded by an intense headache
9
Q
- What type of stroke is usually rapid and are preceded by an intense headache
- What is a collection of blood that collects as a result of a ruptured vessel
- What is an excessive collection of CSF fluid within the ventricles of the brain?
A
- Hemorrhagic Stroke
- Hematomas
- Hydrocephalus
10
Q
- Hemorrhage Stroke CT Protocol?
- How does it appear on image?
- What is a Hematoma?
- Results In?
A
- Brain without contrast
- blood from ruptured vessel will appear denser than the surrounding brain tissue
- a collection of blood that collects as a result of a ruptured vessel
- pressure on brain tissue and an increase in intracranial pressure
- distention of ventricles of brain and atrophy of brain tissue
11
Q
- What is Hydrocephalus?
- Causes? - Hydrocephalus can lead to/result in:
- What is Spondylosis?
A
- An excessive collection of CSF fluid within the ventricles of the brain
- flow of CSF fluid through brain is obstructed, or if an increase amount of CSF produced - distension of the ventricles of the brain and atrophy of brain tissue
- Spondylosis– occurs when there is hypertrophy of the facets of a vertebra.
12
Q
- What is result if flow of CSF fluid through brain is obstructed, or if an increase amount of CSF produced?
- What is Spondylolysis
- What is Spondylolisthesis
A
- Hydrocephalus
- occurs when there is damage to the pars interarticularis of a vertebra.
- occurs when an upper vertebral body slips over a lower vertebral body.
13
Q
- How remember the different Spondys?
- Causes of Herniated Discs?
- What is a Herniated Disc?
A
- LOSIS = Hypertrophy Facet
LOLYSIS = Damage Pars
LOLITHESIS = Upper Slips Over Lower - Degenerative disease or trauma.
- Result of the nucleus pulposus pushing through a weakened annulus fibrosus, which results in the nucleus pulposus putting pressure on the spinal cord
14
Q
- What’s result of the nucleus pulposus pushing through a weakened annulus fibrosus & putting pressure on spinal cord?
- What is the nonaeration or collapse of a lung or part of a lung?
- What is a lung infection that is often caused by bacteria, viruses, or mycoplasmas?
A
- Herniated Disc
- Atelectasis
- Pneumonia
15
Q
- What CT may diagnose Herniated Disc?
- What is Atelectasis?
- Where does Atectasis begin?
A
- Myelogram
- is the nonaeration or collapse of a lung or part of a lung
- Alveoli
16
Q
- When can occur if Atelectasis is not treated?
- Symptoms of Atelectasis
- How does Atelectasis appear on image
A
- If lungs are not reinflated quickly, the lung tissue can become necrotic, infected, and cause permanent damage
- dyspnea, increased heart rate and respiratory rate, and chest pain.
- May present with pleural thickening, pleural effusion, or an airless lung
17
Q
- What condition appears as pleural thickening, pleural effusion, or an airless lung
- What appears as areas of patchy infiltrates or densities within the lungs?
- What refers to air in the pleural cavity?
A
- Asctecalitis
- Pneumonia
- Pneumothorax
18
Q
- What is Pneumonia caused by?
- Result in? - Pneumonia impacts:
- How does Pneumonia appear on image?
A
- lung infection caused by bacteria, viruses, or mycoplasmas
- results in inflammation of the lung. - impact a lobe, segment, bronchi, or interstitial tissue of the lung
- as areas of patchy infiltrates or densities within the lungs.
19
Q
- What is a Pneumothorax?
- Symptoms - This can develop to / result in?
- Pneumothorax Appearance on an image?
A
- refers to air in the pleural cavity.
- atelectasis, dyspnea, cough, and chest pain. - Hypoxia
- sympathetic response - no lung markings within the thorax, where the lung would be expected.
20
Q
- What condition appears as no lung markings within the thorax, where the lung would be expected
- What is the presence of excessive fluid in the pleural cavity?
- What is blunting of the costophrenic angles on imaging?
A
- Pneumothorax
- A pleural effusion
- Pleural Effusion
21
Q
- How does pleural effusion appear on image?
- What is pleural effusion?
- What determines severity? - What can pleural effusion lead to?
A
- blunting of the costophrenic angles on imaging.
- the presence of excessive fluid in the pleural cavity.
- type and rate of accumulation of fluid. - increases the pressure in the pleural cavity and causes separation of the pleural membranes, preventing cohesion during inspiration
- Atelectasis / Vena Cava impaired
22
Q
- What condition increases the pressure in the pleural cavity and causes separation of the pleural membranes, preventing cohesion during inspiration?
- What is Cystic Fibrosis
- Where does Cystic Fibrosis affect?
A
- Pleural Effusion
- inherited disorder in children, linked gene on the 7th chromosome, and causes abnormally thick secretions
- lungs and pancreas where sticky mucus obstructs passages
23
Q
- How does Cystic Fibrosis appear?
- CT Protocol for Cystic Fibrosis?
- What is chronic respiratory disorders that are characterized by progressive tissue degeneration and obstruction of the airways?
A
- bronchial thickening, bronchiectasis, cysts formation, and overinflation of the lungs and chest wall on imaging
- Air Trapping - CT High Resolution Chest
- Chronic Obstructive Pulmonary Disease
24
Q
- What condition may appear as bronchial thickening, bronchiectasis, cysts formation, and overinflation of the lungs and chest wall on imaging
- What is COPD?
- COPD appearance on image?
A
- Cystic Fibrosis
- Chronic Obstructive Pulmonary Disease
- chronic respiratory disorders that are characterized by progressive tissue degeneration and obstruction of the airways - thickening of the bronchial wall, air trapping, and narrowing of the trachea in CT.
25
Q
- What condition appears as thickening of the bronchial wall, air trapping, and narrowing of the trachea in CT?
- What is usually a secondary problem that develops with cystic fibrosis or COPD?
- most common type of malignant tumor?
- type of cell?
A
- COPD
- Bronchiectasis
- Bronchogenic carcinoma is
- squamous cell carcinoma
26
Q
- COPD leads to / results in?
- What is Bronchiectasis caused by?
- What is Bronchiectasis?
A
- irreversible and progressive damage to the lungs and may eventually cause respiratory failure.
- Secondary problem that develops with cystic fibrosis or COPD
- is an irreversible abnormal dilation of the medium sized bronchi and is the result of inflammation and infection in the airways
27
Q
- Bronchiectasis leads to?
- What CT Protocol used for Bronchiectasis?
- How does it appear on an image?
A
- lead to and obstruction of the airway or weakening of the muscles and elastic fibers in the bronchial walls
- CT High Resolution Chest
- dilated airways, thickening of bronchial walls, and obstruction of the airways.
28
Q
- What condition appears as dilated airways, thickening of bronchial walls, and obstruction of the airways?
- What is a blood clot or mass of material that obstructs the pulmonary artery or a branch of it.
- Most common location of cancer?
A
- Bronchiectasis
- A pulmonary embolus
- Lungs
29
Q
- What is a pulmonary embolism?
- Where do pulmonary embolism typically come from?
- Result in? - Protocol for Pulmonary Embolism?
A
- a blood clot or mass of material that obstructs the pulmonary artery or a branch of it.
- blood clots that originate from the deep leg veins
- block arteries - LOC
- Respiratory impairment.
- Crushing chest pain - CTA Chest / Arterial Phase
30
Q
- Positive PE appearance on image?
- What is Bronchogenic carcinoma
- Where is it developed?
A
- filling defects within the vessels of the lungs, and a filling defect may occur in the location of the emboli.
- most common type of malignant tumor, and squamous cell carcinoma
- develops from the epithelial lining of the bronchus near the hilum
31
Q
- What condition show filling defects within the vessels of the lungs?
- Which carcinoma are usually found in the periphery of the lungs?
- Why does CT help diagnosis lung cancer?
A
- Pulmonary Embolism
- . Adenocarcinoma and bronchoalveolar
- CT has the ability to demonstrate small lung nodules and can help to differentiate between benign and malignant tumors.
32
Q
- Difficult tumors to diagnosis in lungs?
- Why? - What is a Dissection?
- CT Protocol for Dissection?
- Why?
A
- Adenocarcinoma and bronchoalveolar cell carcinomas
- in the periphery of the lungs - When there is a tear in the intima and blood flows between the layers of the arterial wall.
-form of aneurysms - Arterial Phase
- Dissection occurs in arteries
33
Q
- What condition occur when there is a tear in the intima and blood flows between the layers of the arterial wall?
- What is Atherosclerosis?
- Where does Atherosclerosis effect/occur?
A
- Dissections
- presence of atheromas
- large arteries like the aorta, iliac arteries, coronary arteries, and the carotid arteries
34
Q
- Type of CT for Atherosclerosis?
- Why? - What is Arteriosclerosis?
- What condition occurs when the coronary artery is totally obstructed which leads to prolonged ischemia and cell death?
A
- CTA b/c occur in arteries & arterial phase is needed to image
- any type of change in an artery. It is often used for the changes occurring in small arteries and arterioles.
- Myocardial Infarction
35
Q
- What does Arteriosclerosis cause & lead to?
- What is Myocardial infarction?
- Three types of Myocardial Infarction
A
- Elasticity is lost and the walls become thick and hard, while the lumen gradually narrows and may become obstructed.
- lead to ischemia and necrosis. - occurs when the coronary artery is totally obstructed which leads to prolonged ischemia and cell death.
- thrombus = build & obstruct the artery
- vasospasm = partial obstruction into a complete obstruction
- part of a thrombus break away / become lodged in coronary artery.
36
Q
- Two types bowel obstruction?
- Differences? - What occurs in a bowel obstruction?
- How does bowel obstruction present on CT?
A
- mechanical, = occurs as result of a physical obstruction
- functional = occurs as a result of a neurological condition. - gas and fluid collect in the bowel
- results in increased pressure and distention. - as distended air filled loops of bowel with thickened walls.
37
Q
- What type of obstruction occurs as a result of a physical obstruction?
- What occcurs when a loop of the bowel pushes through an opening of the abdomen?
- What type of obstruction occurs as a result of a neurological condition?
A
- mechanical
- Hernia
- functional
38
Q
- What condition presents as distended air filled loops of bowel with thickened walls?
- What is a Hernia?
- Caused By? - What is an Inguinal Hernia?
- Location?
A
- Bowel Obstruction
- occurs when a loop of the bowel pushes through an opening of the abdomen.
- result of a weakness in the muscle wall of the abdomen. - In men, the bowel loop may herniate into the scrotum, which is known as an inguinal hernia.
39
Q
- What is herniation into the scrotum known as?
- What is the inflammation of the appendix referred to as?
- Caused By? - Where is appendix located?
A
- an inguinal hernia
- Appendicitis
- the result of an obstruction, inflamed and distended which impacts the blood supply - end of the large intestine (colon) on the right side of the lower abdomen
- RLQ
40
Q
- How may appendicitis appear on image?
- Protocol for Appendicitis?
- Another name for Urolithasis
A
- dilated appendix with a thickened wall that enhances with contrast.
- May have appendicolith present. - Abdomen With Contrast
- calculi / stone
41
Q
- What condition appears as dilated appendix with a thickened wall?
- How is this imaged? - When are Calculi formed?
- What do Calculi mostly consist of?
A
- Appendicitis
- With contrast enhancement - Calculi form when excessive amounts of insoluble salts in the filtrate or when insufficient fluid intake creates concentrated filtrate.
- Calcium
- Some Uric Acid
42
Q
- What can calculi located in kidney cause?
- Protocol for urolithiasis?
- How does urolithiasis appear on CT?
A
1 Infection or Hydronephrosis
- Abdomen/Pelvis WITHOUT contrast
- urolithiasis = dense objects within the urinary tract.
43
Q
- How do Cysts appear on image?
- The HU for a simple renal cyst should be ______.
- What causes Hydronephrosis?
A
- Simple renal cysts typically have well-defined margins and do not enhance with contrast.
- less than 10 HU.
- occurs as a secondary problem,
- from calculi, tumors, scar tissue, or prostatic enlargement.
44
Q
- Is contrast used to diagnose / enhance the following:
- Appendicitis
- Uthelisis
- Cyst
- Crohns - What can occur if urine builds up in ureter / kidneys?
- What area does Pyelonephritis effect?
A
- APPY = YES
- CALCI = NO
- CYST = NO
- Crohns = YES - Necrosis of Tissues
- Sepsis / Infection - extend from the ureter into the kidney and involve the renal pelvis
45
Q
- Typical cause of Polycystic Kidney?
- Typical age of diagnosis?
- What may result / may be needed? - Polycystic kidney presents as ____ with an HU of less than _______.
A
- Genetic / Autoimmune
- 40 y/o
- chronic renal failure becomes symptomatic and dialysis is required - many simple cysts on B/L kidneys
- 10
46
Q
- HU for polycystic kidney cyst?
- What is Crohn’s disease?
- Effects what area? - How does Crohns appear on CT?
A
- Less than 10
- chronic inflammation of the bowel wall, which can lead to the thickening of the wall.
- Small intestine, & sometimes colon - thickening of the bowel wall and the mucosa will enhance with the administration of IV contrast.
47
Q
- What condition is the chronic inflammation of the bowel wall, which can lead to the thickening of the wall
- What is the primary tumor arising from the tubule epithelium, or renal cortex?
- What is a Wilms Tumor?
A
- Crohns
- Renal cell carcinoma
- rare tumor occurring in children. It is associated with defects in the tumor suppressing genes
48
Q
- How does Renal Cell Carcinoma present on an image?
- Is contrast advised? - Wilm’s tumor is usually diagnosed by what age?
- Condition that appears as thickening of the bowel wall and the mucosa on CT?
A
- as lesions that enhance during the corticomedullary phase of contrast enhancement
- the age of 3 or 4
- Crohns
49
Q
- How does Wilm’s tumor present on image?
- What is Pancreatitis?
- How does Pancreatitis appear on CT?
A
- as an enhancing heterogeneous soft tissue mass.
- Inflammation of the pancreas that is a result of the digestion of tissues by pancreatic enzymes.
- present with parenchyma enlargement, changes in density, and fat stranding.
50
Q
- A heterogenous soft tissue mass on a child’s CT may be diagnosed as:
- What condition presents with parenchyma enlargement, changes in density, and fat stranding on CT?
- What is typically caused by smoking & tumors in head of pancreases?
A
- Wilms Tumor
- Pancreatitis
- Pancreatic Carcinoma
51
Q
- Two locations of Pancreatic Carcinoma:
- Differences? - Are Pancreatic tumors visible on CT?
- What is a benign neoplasm consisting of blood vessels that is typically circular in shape and solitary?
A
- head of the pancreas = obstruction, weight loss, Jaund
- tail of the pancreas = asymptomatic until the cancer is in advanced stages.
- head of the pancreas = obstruction, weight loss, Jaund
- head of the pancreas = visible when there is barium present in the small bowel
- Hemangioma
52
Q
- How do Tumors appear on CT?
- What is hemangioma
- In CT with IV contrast, a hemangioma will appear:
A
- poorly defined masses that are less enhanced than the surrounding areas. - They will appear as hypodense on arterial phase, and isodense on delayed phase imaging
- benign neoplasm consisting of blood vessels that is typically circular in shape and solitary
- have contrast enhancement at the edges of the neoplasm.
53
Q
- What is the condition that progressive destruction of the liver tissue, which leads to eventual liver failure.
- What condition appears as hypertrophy of the caudate lobe of the liver, the liver becoming more fatty, and heterogeneous parenchyma in both pre and post contrast imaging?
- What condition appears as poorly defined masses that are less enhanced than the surrounding areas?
A
- Cirrhosis
- Cirrhosis
- Tumors
54
Q
- How do Tumors appear in each phase?
- What is Cirrhosis?
- What does it lead to?
- How classified?
A
- hypodense on arterial phase,
- isodense on delayed phase
- less enhanced on dry scan - is the progressive destruction of the liver tissue, which leads to eventual liver failure.
- Liver Failure
- Cirrhosis classified based upon the changes that occur within the liver, or the cause of the disorder
55
Q
- What does fatty liver indicate?
- What is Ascites?
- How does Cirrhosis appear on CT?
- Is contrast indicated?
A
- Cirrhosis
- Ascites is the accumulation of fluid within the peritoneal cavity.
- hypertrophy of the lobe of the liver, the liver more fatty, and heterogeneous parenchyma
- both pre and post contrast imaging
56
Q
- Most common liver tumor?
- How does this tumor appear on image?
A
- Hepatocellular carcinoma
- enhancing during the late arterial phase of contrast enhancement, followed by the contrast quickly washing out
- nondistinct during portal venous phase
57
Q
- How does Hepatocellular carcinoma appear on CT?
- Is contrast indicated? - What causes this carcinoma / where located?
- What is the inflammation of a tendon?
A
- enhancing during the late arterial phase of contrast enhancement, followed by the contrast quickly washing out
- Non-Distinct during portal venous - Cirrhosis causes
- occurs in liver - Tendinitis
58
Q
- What is tendinitis?
- Causes? - What CT protocol is used to diagnose tendinitis?
- What is a metabolic bone disorder that results in a decrease in bone mass and density?
A
- Inflammation of tendon
- Trauma or repetitive use - Arthrogram
- Osteoporosis
59
Q
- What is Osteoporosis?
- What occurs in Osteoporosis?
- What is Osteomyelitis
A
- Metabolic bone disorder that results in a decrease in bone mass and density
- bone resorption exceeds bone formation, which leads to thin and fragile bones that are subject to spontaneous fractures.
- Osteomyelitis is a bone infection caused by bacteria.
60
Q
- What is condition when bone resorption exceeds bone formation?
- This results in? - What is a bone infection caused by bacteria?
- What condition appears as swelling and blurring of the adjacent tissue on an image?
A
- Osteoporosis
- leads to thin and fragile bones that are subject to spontaneous fractures. - Osteomyelitis
- Osteomyelitis
61
Q
- Osteomyelitis appearance on CT?
- Osteoarthritis appearance on CT?
- Ewing Sarcoma appearance on CT?
A
- swelling and blurring of the adjacent tissue on a CT image.
- narrowing or erosion of the joint space on CT.
- appears as an aggressive tumor, with multiple small, poorly defined lesions
62
Q
- What is the condition that arises when the articular cartilage is damaged or lost and there is a disintegration of cartilage
- What is Ewing Sarcoma?
- Who is effected by Ewing?
- Where does it effect?
A
- Osteoarthritis
- malignant form of cancer, tumors often grow in the medullary cavity of the long bone & pelvis
- 5 - 20 y/o
- Long Bones & Pelvis
63
Q
- What condition appears as aggressive tumor, with multiple small, poorly defined lesions?
- What condition is malignant form of cancer where tumors are very aggressive and grow in the metaphysis of long bones?
- What is a neoplastic disease that involves the plasma cells?
A
- Ewing
- Osteogenic sarcoma
- Multiple Myeloma
64
Q
- What is Osteogenic Sarcoma?
- Area effected? - CT Protocol typically used for Osteogenic Sarcoma
- What is group of neoplastic disorders involving the white blood cells
A
- malignant form of cancer where tumors are very aggressive and grow in the metaphysis of long bones
- guide in a biopsy and to assess for metastases.
- leukemias
65
Q
- Four types of leukemia:
- What is CT used for with Leukemia?
- What is Hodgkin Lymphoma?
- Area effected?
A
- acute lymphocytic leukemia, - chronic lymphocytic leukemia,
- acute myelogenous leukemia,
- chronic myelogenous leukemia.
- acute lymphocytic leukemia, - chronic lymphocytic leukemia,
- assess the extent of the disease and for staging.
- Decrease lymphosites
- Start one lymph node if neck and moved to other
66
Q
- Typical age of Hodgkin’s lymphoma?
- Typical area? - Typical marker for Hodgkin?
- How is Hodgkin assessed?
A
- 20-40
- Lymph Nodes / Starts Neck - Reed-Sternberg cells
- Ann Arbor Staging
- CT Used
67
Q
- Typical age of Hodgkin’s lymphoma?
- Typical area? - Typical marker for Hodgkin?
- How is Hodgkin assessed?
A
- 20-40
- Lymph Nodes / Starts Neck - Reed-Sternberg cells
- Ann Arbor Staging
- CT Used
68
Q
- Hodgkin vs Non-Hodgkin Lymphoma?
- What is Multiple myeloma?
A
- Hodgkin = Lymphnodes of specific area
- Non = multiple node involvement scattered throughout the body in no specific pattern - a neoplastic disease that involves the plasma cells
- tumors with bone destruction tend to develop
3.