Pathology Flashcards
Most common type of Basal Cell Carcinoma?
Nodular
Differentiating between Ossifying fibroma and fibrous dysplasia?
Fibrous Dysplasia will show strong immunoreactivity for osteocalcin and GNAS mutation on PCR.
Management of Ossifying Fibroma
Complete Enucleation.
Management of Fibrous Dysplasia
Non-surgical.
Bisphosphonates.
What percentage of patients over 40 have Osteoarthritis?
10% of men and 13% of women have symptomatic osteo arthritis of knee. 25% of patients have radiographic evidence of knee.
ORNJ Stages
0= non-exposed bone
1= exposed necrotic bone or fistulae that probes to bone; no infection
2= 1+ infection
3= 2 + pathologic fracture- or extends to inferior border or sinus floor or communicates with antrum.
Why is BRONJ now called MRONJ
Denosumab (Rani-L inhibitor)
Lesion associated with impacted canine?
Adennomatoid Odontogenic Tumor
Aspergillosis branching
ACUTE angles
Mucormycosis Branching
Right or Obtuse angles. Tx: Amphotericin B
Pemphigus vulgaris affects?
Desmoglein 3
-Fish net pattern
Pemhagoid Immunofluorescence pattern?
Linear.
Attacks basement membrane.
Central feature of Calcifying Odontogenic cyst
Ghost cells. Generally radiolucent but sometimes with calcifications within.
Central giant cells occur predominantly….
In Anterior mandible of young adults.
Most common type of osteosarcoma
Chondroblastic osteosarc.
Most common type of rhabdosarcoma?
Embryonic
Lesion on palate with palisaded spindle cells, painful and S100 positive
Schwanoma.
S100 found in melanomas, neurofibromas, and nerve sheath tumors.
Most common types of rhabdomyosarcoma of the H&N.
Embryonal, then alveolar, and pleomorphic
Most common type of osteosarcoma of the H&N
Chondroblastic then Osteoblastic, then Fibroblastic.
Radiation for SCC of floor of mouth
Optional in N0 unless positive margin or high risk features.
Always in N1+ ds. Consists of 60-70 Gy 6-7 weeks post op or 44-55Gy if low/intermediate risk. Or higher risk 72Gy +. Radiation Sarcoma is a risk over 40Gy.
Trigeminal neuralgia has paroxysmal or continuous pain
Paroxysmal
What non-malignant jaw lesions need a resection?
All ameloblastomas, CEOT, Myxoma, Odontoameloblastoma.
Tx of OKC
Enucleation with peripheral ostectomy and or cryotherapy.
Aneurysmal bone cyst
Develops secondarily from another bone lesion. Usually Central Giant Cell.
Giant cell lesion marker
CD68
Radical neck dissection removes
Zones 1-5 + spinal accessory nerve, IJ + SCM.
Modified radical neck dissection removes
Type 1 preserves spinal accessrry nerve
Type 2 preserves spinal accessory. nerve and IJ
Type 3 preserves SAN, IJV, SCM.
Selective neck dissection remmoves
Just specified levels of lymph tissue. For most oropharyngeal lesions a level 2-4 SND is done.
What salivary gland tumor is almost exclusively minor gland?
Polymorphous Low-grade Adenocarcinoma.
When is the best time to remove an AVM after embolization
1-3 days
Bone mets to the jaw come from
Breast then lung in women.
How to treat ulcerative stomatitis?
Hydroxychloroquine.
What does cavernous sinus thrombosis affect first?
CN 6- abducens nerve.
Borders of retropharyngeal space infection?
Buccopharyngeal fascia anteriorly and prevertebral fascia posteriorly
Treatment for chondrosarcoma?
Low grade= 1.5cm bony and soft tissue margins. High grade= 3cm bony and 2cm soft tissue margins with pre and post surgery chemotherapy.
Treatment of 0.5cm pleomorphic adenoma in parotid?
Superficial parotidectomy.
MEN I
3 Ps pituitary, parathyroid, pancreas.
MEN IIa
1M, 2Ps. Medullary thyroid, pheochromocytoma, parathyroid
MEN 2b
2Ms, 1P. Medullary Thyroid, Marfanoid habitus/Mucosal neuromas and pheochromocytoma.
What are the most common malignant tumors of minor and major salivary glads?
Mucoepidermoid Carcinoma in the parotid
Adenoid cystic carcinoma in the submandibular, sublingual, and salivary glands.
What is the most common benign tumor of minor and major salivary glands?
Pleomorphic adenoma.
