Pathology

Question 1

STD, commonly affects vulva, vesicles?

Answer 1

HSV

*molluscum contagiosum

Question 2

STD, intraepithelial dysplasia, invasive carcinoma?

Answer 2

HPV

Question 3

STD, cervicitis, endometritis, salpingo-oophoritis?

Answer 3

Chlamydia trachomatis

Question 4

Skene gland adenitis, cervicitis, endometritis, Salpingitis?

Answer 4

GC

Question 5

Endogenous, vuvlovaginitis?

Answer 5

Candida

Question 6

STD, cervicovaginitis?

Answer 6

Trichomonas

Question 7

Straight glands w/ pseudo-stratified epithelium
Negative for Mucin production
Stroma= spindle cells, scant cytoplasm, high mitotic rate?

Answer 7

Proliferative phase of endometrium

Question 8

Endometrial carcinoma that is estrogen responsive. What are the risk factors?

Answer 8

Type 1: Age, Obesity, unopposed estrogen, nulliparity, DM, HTN, PCOD

Question 9

What genetics is associated with Endometrioid and non-endometrioid endometrial carcinomas?

Answer 9

Endometrioid== PTEN 
Non-endo== p53

Question 10

Recurrence of endometrial carcinoma most commonly occurs where?

Answer 10

Vaginal Vault
Pelvis
Abdomen
Lungs

Question 11

Cardinal sign of endometrial carcinoma?

Answer 11

Abnormal uterine bleeding

Question 12

3 most common types of Ovarian carcinomas?

Answer 12

Serous= 75%
Endometrioid==10%
Mucinous== 10%

Question 13

What are the risk factors for Ovarian cancer?

Answer 13

Age (40-49 or >70)
Early menarche 
Late menopause
FHx (BRCA)
Endometriosis
Smoking

Question 14

MC sites of Distant metastasis of Ovarian cancer?

Answer 14

Peritoneum
other ovary
Lymph nodes
Liver/ lungs

Question 15

Women with bloating, abdominal enlargement, urinary urgency?

Answer 15

Ovarian Carcinoma

Question 16

female with pelvic mass, ascites, abdominal mass, decreased breath sounds/dullness to percussion over lungs?

Answer 16

Meigs Syndrome= Benign Ovarian tumor + pleural effusion

Question 17

What is a screening test for ovarian cancer?

Answer 17

Ultrasound + CA-125 (stage 3)

Question 18

Induces rapid degeneration of p53 by ubiquitin-dependent proteolysis?

Answer 18

HPV E6 protein

Question 19

Complexes with Hypophosphorylated active form RB protein promoting proteolysis, and removing Rb inhibition of S-phase entry via E2F?

Answer 19

HPV E7

Question 20

What is the characteristic of CIN I?

Answer 20

Koliocytotic atypia= large nuclei with halo

Question 21

What is the characteristic of CIN II?

Answer 21

Pleomorphic atypia

Question 22

What is CIN III?

Answer 22

Carcinoma in situ= the entire depth of tissue

Question 23

What is the late onset symptom of Cervical cancer?

Answer 23

BLEEDING

Question 24

Some of the signs for Cervical caner?

Answer 24

Bleeding
White patches with Acetic acid preps
Flat ulcers
abnormal vascular pattern

Question 25

Coffee bean nuclei

Call-exner bodies?

Answer 25

Granulosa-theca cell tumor

Question 26

Schiller duval bodies?

Answer 26

Yolk sac tumor= Alpha fetoprotein

Question 27

Yellow/green frothy vaginal discharge + Strawberry cervix?

Answer 27

Trichomonas= Whiff test, protozoa

Question 28

Lower abdominal pain
Adnexal tenderness
Discomfort upon cervical palpation?

Answer 28

PID== MCC GC

Question 29

What is the Schiller test (acetic acid) test used for?

Answer 29

CIN/ HPV infections== Turns abnormal mucosa white

Question 30

Koilocytic change
Desmoplastic change
Keratin pearls in Pap smear?

Answer 30

Cervical SCC

Question 31

Straight glands
No mucin
edematous stroma?

Answer 31

Follicular phase

Question 32

Basal vacuoles w. decreased mitotic activity?

Answer 32

Early secretory phase (luteal phase)

Question 33

Tortuous, corkscrew dilated glands with mucin production, spiral arteries and beginning of decidulaization?

Answer 33

Late secretory phase

Question 34

What does inactivation of PTEN cause?

Answer 34

Increase sensitivity of Endometrium to Estrogen = Hyperplasia and CANCER