Pathology

Question 1

3 antibodies tested for anti-phospholipid syndrome

Answer 1

Lupus anticoagulant
Anti-cardiolipin
Anti-beta2-glycoprotein

Question 2

Cancer associated with Li-Fraumeni syndrome

Answer 2

Sarcomas, Leukaemia, breast, CNS and Adrenal cancer

Question 3

Cancer associated with von Hippel-Lindau Syndrome

Answer 3

renal cell carcinoma
Pheochromocytomas
Haemangioblastomas

Question 4

Side effects of cyclophosphamide

Answer 4

Haemorrhagic cystitis

Cyclophosphamide is used as a part of CHOP regime for lymphoma

Haemorrhagic cystitis can cause frank haematuria

Question 5

Side effects of paclitaxel

Answer 5

Anti-microtubule agent

Used for ovarian/breast cancer, Kaposi sarcoma,

Question 6

Side effects of Cisplatin

Answer 6

Causes inhibition of DNA, RNA and protein synthesis

Platinum based heavy metal complex.
Nephrotoxic, Neurotoxic, Ototoxic

Question 7

Side effects of Capecitabine

Answer 7

Neutropenic enterocolitis

Question 9

S phase specific chemo drug mimics it’s ok and is incorporated into RNA

Answer 9

5FU
Capecitibine is an oral prodrug

Question 10

Chemo drug that inhibits DNA and RNA synthesis by intercalating base pairs and inhabits DNA coiling, severe cardiotoxicity

Answer 10

Doxorubicin

Question 11

Chemo drug that inhibits topoisomerase II to present efficient DNA coiling

Answer 11

Etoposide

Question 12

Chemo drug crosslinks DNA, which distorts molecule and induces apoptosis

Answer 12

Cisplatin

Question 13

Chemo drug that uses phosphoramide mustard forms DNA crosslinks and causes the cell death

Answer 13

Cyclophosphamide

Question 14

Chemo drugs that disrupt microtubule formation

Answer 14

Docetaxal

Question 15

Bilateral epididymal papillary cystadenomas is pathognomonic for which condition?

Answer 15

von Hippel-Lindau disease
VHL gene, tumour suppressor gene