Cancer

Question 1

Adalimumab/Infliximab/Etacercept’s target and conditions they are used for

Answer 1

TNF alpha inhibitor

Crohn’s, RA

Question 2

Bevacizumab’s target and conditions used for

Answer 2

Anti angiogenesis, Anti VEGF

CRC, Renal, Galioblastoma

Question 3

Trastuzumab’s target and condition used for

Answer 3

HER receptor
HER receptor +ve cancers e.g. Breast, Gastric

Question 4

Imatinib’s target and condition used for

Answer 4

Tyrosine kinase inhibitor
GIST
CML

Question 5

Basiliximab

Answer 5

IL2 binding site
Renal transplant

Question 6

Cetuximab’s target and condition used for

Answer 6

Epidermal growth factor inhibitor
EGF +ve CRC

Question 7

CTx regime for non-metastatic pancreatic Ca

Answer 7

Gemcitabine + Capecitabine

Question 8

CTx regime for metastatic pancreatic Ca

Answer 8

FOLIRINOX
FOLinic acid
Fluorouracil
IRINotecan
OXaliplatin

Question 9

Common adjuvant CTx regimen for breast Ca

Answer 9

Taxane (e.g. Docetaxel, Paclitaxel)
Anthracylcine (Doxotubicin)
Add Capecitabine if mets

Question 10

Common neoadjuvant CTx regimen for breast Ca

Answer 10

3 x FEC (Fluorouracil + Epirubicin + Cyclophosphamide)
+
3 x Taxane

If triple negative invasive breast ca: Platinum + Anthracyclin (e.g. Doxotubicin)

Question 11

mode of action of Fluorouracil

Answer 11

S phase specific antimetabolite drug
Mimics uracil and is incorporated into RNA

Question 12

mode action of Doxorubicin

Answer 12

Anthracycline
Inhibits DNA and RNA synthesis by intercalating base-pairs and inhibits DNA coiling

Question 13

Mode of action of Etoposide

Answer 13

Topoisomerase inhibitors
Inhibits topoisomerase II
Prevents efficient DNA coiling

Question 14

Mode of action of Cisplatin

Answer 14

Platinum
Crosslink DNA, resulting in distortion of molecule and induces apoptosis

Question 15

Mode of action of Cyclophosphamide

Answer 15

Phosphoramide mustard forms DNA cross links causing cell death

Question 16

Mode of action of Docetaxal

Answer 16

Disrupts microtubule formation