pathogenesis of autoimmune disease Flashcards
where is the site of inflammation in rheumatoid arthritis?
synovium
which antibodies are associated with rheumatoid arthritis?
Rheumatoid factor (antibody)
Anti-cyclic citrullinated peptide (CCP) antibodies
what is ankylosing spondylitis?
Chronic spinal inflammation that can result in spinal fusion and deformity
arthritis but no rheumatoid factor/ antibodies
where is the site of inflammation in ankylosing spondylitis?
in the enthesis
the connective tissue between tendon or ligament and bone
what is systemic lupus erythematosus?
an abnormal production of white blood cells.
Chronic tissue inflammation in the presence of antibodies directed against self antigens
which antibodies are associated with lupus?
Antinuclear antibodies
Anti-double stranded DNA antibodies
what are the associated HLA molecules with rheumatoid arthritis, lupus and ankylosing spondylitis?
RA: HLA-DR4
SLE: HLA-DR3
AS: HLA-B27
what are antinuclear antibodies?
autoantibodies that bind to contents of the cell nucleus
what is the relationship between the level of complement in the blood and the leves of anti-ds-DNA antibodies in a sick lupus patient?
low complement levels when high serum levels of anti-ds-DNA antibodies
give some cytokines involved in rheumatology?
y-IFN IL1 IL2 IL6 TNFa (key cytokine involved in rheumatoid arthritis)
what cytokine is important in bone destruction in rheumatoid arthritis?
receptor activator of nuclear factor kappaB ligand
RANKL
what is the use of prostaglandins in rheumatology?
lipid mediators of inflammation that act on platelets, endothelium, uterine tissue and mast cells
