Pathogen/DOC

Question 1

VRE (E. faecalis)

Answer 1

• Pen G or ampicillin
• Linezolid (Zyvox)
• Daptomycin (Cubicin)
• Tigecycline
• Cystitis only: Nitrofurantoin, fosfomycin, doxyxyxline

Question 2

VRE (E. faecium)

Answer 2

• Linezolid (Zyvox)
• Daptomycin (Cubicin)
• Tigecycline
• Quinupristin/Dalfopristin (synercid)
• Cystitis only: Nitrofurantoin, fosfomycin, doxyxyxline

Question 3

Pseudomonas

Answer 3

• Piperacillin/Tazobactam (Zosyn)
• Cefepime
• Ceftazidime
• Ceftazidime/Avibactam (Avycaz)
• Ceftolozane/Tazobactam (Zerbaxa)
• carbapenems (except Ertapenem)
• Ciprofloxacin/Levofloxacin
• Aztreonam
• Aminoglycosides
• Colistimethate, Polymyxin B

Question 4

B. Fragilis

Answer 4

• Metronidazole
• Beta-lactam/beta-lactamase inhibitor
• Cefotetan, cefoxitin
• Carbapenems
• Tigecycline

Question 5

C. difficile

Answer 5

• Vancomycin (PO)
• Fidaxomicin
• Metronidazole

Question 6

Severe SSTIs requiring IV Treatment or hospitalization (cover MRSA, and streptococci)

Answer 6

• Vancomycin ( consider alternative if MIC >2)
• Linezolid, Tedizolid
• Daptomycin
• Ceftaroline
• Tela/Orita/Dalba- Vancin
• Quinupristin/Dalfopristin
• Tegacycline