DYSLIPIDEMIA Flashcards
LDL FORMULA
LDL = TC - HDL - TG/5
REMEMBER NOT TO USE THIS FORMULA WHEN TG IS > 400MG/DL
DRUGS THAT INCREASE LDL AND TG
- PIs
- STEROIDS
- DIURETICS
- IMMUNOSUPRESANTS
DRUGS THAT INCREASE LDL ONLY
- FIBRATES
- SGLT2 INH
DRUGS THAT INCREASE TG ONLY
- IV LIPID EMULSIONS
- PROPOFOL
- BB
- ATYPICAL ANTIPSYCHOTICS
CONDITIONS THAT INCREASE CHOLESTEROL
- OBESITY
- HYPOTHYROIDISM
- ALCOHOLISM
- DIABETES
- RENAL/LIVER DISEASE
EXAM SCENARIO EXAMPLE CALCULATE LDL TC= 202MG/DL HDL = 36MG/DL TG = 280MG/DL
LDL = 110
IF PATIENT IS BETWEEN AGE 40-75, LDL 70-189MG/DL AND :
A) 10 YEAR ASCVD RISK IS = OR > 20% =, WHAT STATATIN NEEDS
B) 10 YEAR ASCVD RISK IS 7.5 - 19.9% + RISK ENHANCING FACTORS, WHAT STATIN NEEDS?
A) HIGH INTENSITY STATIN
B) MODERATE INTENSITY STATIN
IF A PATIENT IS DIABETIC, AGE 40 -75 YEARS WITH LDL 70-189MG/DL AND:
A) MULTIPLE ASCVD RISK FACTORS, WHAT STATIN NEEDS?
B) REGARDLES OF 10 YEAR ASCVD RISK, WHAT STATIN NEEDS?
A) HIGH INTENSITY STATIN
B) MODERATE INTENSITY STATIN
IF PATIENT PRIMARY ELEVATION OF LDL = OR > 190MG/DL, WHAT STATIN PATIEN NEEDS?
HIGH INTENSITY STATIN
FOR SECONDARY PREVENTION , CLINICAL ASCVD ( THIS INCLUDES CHD, STROKE, TIA, PERIPHERAL ARTERIAL DISEASE)
HIGH INTENSITY STATIN
WHAT ARE HIGH INTENSITY STATINS?
ATOVASTASTIN 40 -80MG
ROSUVASTATIN 20-40MG
HOW MUCH A DAILY DOSE OF HIGH INTENSITY STATIN REDUCE LDL?
REDUCE + OR > 50%
WHICH STATINS ARE MODERATE INTENSITY STATINS?
- ATOVASTATIN 10-20 MG
- ROSUVASTATIN 5-10 MG
- SIMVASTATIN 20-40 MG
- PRAVASTATIN 40-80 MG
- LOVASTATIN 40MG
- FLUVASTATIN XL 80 MG
- FLUVASTATIN 40MG
- PITAVASTATIN 2-4MG
STATIN EQUIVALENT DOSES
REMEMBER Pharmacists Rock At Saving Lives and Preventing Fatty deposits
- PITAVASTATIN 2mg
- ROSUVASTATIN 5-mg
- ATOVASTATIN 10mg
- SIMVASTATIN 20mg
- LOVASTATIN 40mg
- PRAVASTATIN 40mg
- FLUVASTATIN 80ml
EXAM SCENARIO
CONVERT SIMVASTATIN 40MG TO ATORVASTATIN DOSE.
ATORVASTATIN 20MG
WHICH STATIN NEEDS TO BE TAKEN AT THE EVENING?
LOVASTATIN AND SIMVASTATIN
WICH STATIN USE LOWER STARTING DOSE WHEN CRCL IS < 30ML/MIN??
SAMANTHA LOVES ROSES AT 30 DOLLARS
SIMVASTATIN, LOVASTATIN AND ROSUVASTATIN
WHICH STATIN USE LOWER STARTING DOSE WHEN CRCL IS < 60ML/MIN?
PITAVASTATIN
WHAT IS THE MAX DOSE PER DAY OF SIMVASTATIN IF TAKING VERAPAMIL, DILTIAZEM, DRONEDARONE?
MAX 10MG/ DAY
WHAT IS THE MAX DOSE PER DAY OF SIMVASTATIN IF TAKING AMIODARONE, AMLODIPINE, RANOLAZINE?
MAX 20MG/ DAY
WHAT IS THE MAX DOSE PER DAY OF LOVASTATIN IF TAKING DILTIAZEM, VERAPAMIL, AMLODIPINE, AMIODARONE, DRONEDARONE?
MAX 20 - 40MG / DAY
WHAT DRUGS YOU SHOULD AVOID IF TAKING ATORVASTATIN?
AVOID CYCLOSPORINE, GEMFIBROZIL, RITONAVIR
WHAT DRUGS ARE OK TO TAKE WITH ATORVASTATIN AT A MAX DOSE OF 20 - 40 MG PER DAY?
CLARITHROMYCIN
COBICISTAT
PI’s
WHAT IS THE MAX DOSE PER DAY ROSUVASTATIN WHEN USE WITH CYCLOPSPORINE ?
MAX DOSE 5MG / DAY
WHATS THE MAX DOSE PER DAY OF ROSUVASTATIN WHEN USE WITH GEMFIBROZIL OR PIs?
MAX DOSE 10MG/DAY
WHAT STRONG CYP3A4 INHIBITORS SHOULD BE AVOID IF TAKING SIMVASTATIN OR LOVASTATIN?
- AZOLES
- MACROLIDES (CLARITHROMYCIN, ERYTHROMYCIN)
- CYCLOSPORINE
- GRAPE FRUIT
WHAT’S THE MX AX OF EZETIMIBE?
INHIBIT ABSORPTION CHOLESTEROL IN THE SMALL INTESNTINE
PCSK9 INH?
ALIROCUMAB ( PRALUENT)
EVOLOCURAMAB ( REPATHA)
WHAT’S MX AX PCSK9 INH?
THEY BIND TO PCSK9 SO THIS DOESN’T DEGRATES LDL RECEPTORS, THERE ARE MORE LDL RECEPTORS AVAILABLE TO CLEAR LDL LOWERING LDL AROUND 60%
WHICH ARE THE BILE ACID SEQUESTRANS AND WHICH ONE IS APPROVE FOR GLYCEMIC CONTROL?
- CHOLESTYRAMINE (PREVALITE)
- COLESEVELAM (WELCHOL)»_space;> APPROVED GLYCECMIC CONTROL
- COLESTIPOL (COLESTID)
FIBRATES?
- FENOFIBRATE
- GEMFIBROZIL
