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Naplex > DYSLIPIDEMIA > Flashcards

DYSLIPIDEMIA Flashcards

1
Q

LDL FORMULA

A

LDL = TC - HDL - TG/5

REMEMBER NOT TO USE THIS FORMULA WHEN TG IS > 400MG/DL

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2
Q

DRUGS THAT INCREASE LDL AND TG

A
  • PIs
  • STEROIDS
  • DIURETICS
  • IMMUNOSUPRESANTS
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3
Q

DRUGS THAT INCREASE LDL ONLY

A
  • FIBRATES

- SGLT2 INH

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4
Q

DRUGS THAT INCREASE TG ONLY

A
  • IV LIPID EMULSIONS
  • PROPOFOL
  • BB
  • ATYPICAL ANTIPSYCHOTICS
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5
Q

CONDITIONS THAT INCREASE CHOLESTEROL

A
  • OBESITY
  • HYPOTHYROIDISM
  • ALCOHOLISM
  • DIABETES
  • RENAL/LIVER DISEASE
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6
Q 
EXAM SCENARIO EXAMPLE
CALCULATE LDL
TC= 202MG/DL
HDL = 36MG/DL
TG = 280MG/DL
A

LDL = 110

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7
Q

IF PATIENT IS BETWEEN AGE 40-75, LDL 70-189MG/DL AND :
A) 10 YEAR ASCVD RISK IS = OR > 20% =, WHAT STATATIN NEEDS
B) 10 YEAR ASCVD RISK IS 7.5 - 19.9% + RISK ENHANCING FACTORS, WHAT STATIN NEEDS?

A

A) HIGH INTENSITY STATIN

B) MODERATE INTENSITY STATIN

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8
Q

IF A PATIENT IS DIABETIC, AGE 40 -75 YEARS WITH LDL 70-189MG/DL AND:
A) MULTIPLE ASCVD RISK FACTORS, WHAT STATIN NEEDS?
B) REGARDLES OF 10 YEAR ASCVD RISK, WHAT STATIN NEEDS?

A

A) HIGH INTENSITY STATIN

B) MODERATE INTENSITY STATIN

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9
Q

IF PATIENT PRIMARY ELEVATION OF LDL = OR > 190MG/DL, WHAT STATIN PATIEN NEEDS?

A

HIGH INTENSITY STATIN

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10
Q

FOR SECONDARY PREVENTION , CLINICAL ASCVD ( THIS INCLUDES CHD, STROKE, TIA, PERIPHERAL ARTERIAL DISEASE)

A

HIGH INTENSITY STATIN

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11
Q

WHAT ARE HIGH INTENSITY STATINS?

A

ATOVASTASTIN 40 -80MG

ROSUVASTATIN 20-40MG

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12
Q

HOW MUCH A DAILY DOSE OF HIGH INTENSITY STATIN REDUCE LDL?

A

REDUCE + OR > 50%

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13
Q

WHICH STATINS ARE MODERATE INTENSITY STATINS?

A
  • ATOVASTATIN 10-20 MG
  • ROSUVASTATIN 5-10 MG
  • SIMVASTATIN 20-40 MG
  • PRAVASTATIN 40-80 MG
  • LOVASTATIN 40MG
  • FLUVASTATIN XL 80 MG
  • FLUVASTATIN 40MG
  • PITAVASTATIN 2-4MG
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14
Q

STATIN EQUIVALENT DOSES

A

REMEMBER Pharmacists Rock At Saving Lives and Preventing Fatty deposits

  • PITAVASTATIN 2mg
  • ROSUVASTATIN 5-mg
  • ATOVASTATIN 10mg
  • SIMVASTATIN 20mg
  • LOVASTATIN 40mg
  • PRAVASTATIN 40mg
  • FLUVASTATIN 80ml
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15
Q

EXAM SCENARIO

CONVERT SIMVASTATIN 40MG TO ATORVASTATIN DOSE.

A

ATORVASTATIN 20MG

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16
Q

WHICH STATIN NEEDS TO BE TAKEN AT THE EVENING?

A

LOVASTATIN AND SIMVASTATIN

17
Q

WICH STATIN USE LOWER STARTING DOSE WHEN CRCL IS < 30ML/MIN??

A

SAMANTHA LOVES ROSES AT 30 DOLLARS

SIMVASTATIN, LOVASTATIN AND ROSUVASTATIN

18
Q

WHICH STATIN USE LOWER STARTING DOSE WHEN CRCL IS < 60ML/MIN?

A

PITAVASTATIN

19
Q

WHAT IS THE MAX DOSE PER DAY OF SIMVASTATIN IF TAKING VERAPAMIL, DILTIAZEM, DRONEDARONE?

A

MAX 10MG/ DAY

20
Q

WHAT IS THE MAX DOSE PER DAY OF SIMVASTATIN IF TAKING AMIODARONE, AMLODIPINE, RANOLAZINE?

A

MAX 20MG/ DAY

21
Q

WHAT IS THE MAX DOSE PER DAY OF LOVASTATIN IF TAKING DILTIAZEM, VERAPAMIL, AMLODIPINE, AMIODARONE, DRONEDARONE?

A

MAX 20 - 40MG / DAY

22
Q

WHAT DRUGS YOU SHOULD AVOID IF TAKING ATORVASTATIN?

A

AVOID CYCLOSPORINE, GEMFIBROZIL, RITONAVIR

23
Q

WHAT DRUGS ARE OK TO TAKE WITH ATORVASTATIN AT A MAX DOSE OF 20 - 40 MG PER DAY?

A

CLARITHROMYCIN
COBICISTAT
PI’s

24
Q

WHAT IS THE MAX DOSE PER DAY ROSUVASTATIN WHEN USE WITH CYCLOPSPORINE ?

A

MAX DOSE 5MG / DAY

25
Q

WHATS THE MAX DOSE PER DAY OF ROSUVASTATIN WHEN USE WITH GEMFIBROZIL OR PIs?

A

MAX DOSE 10MG/DAY

26
Q

WHAT STRONG CYP3A4 INHIBITORS SHOULD BE AVOID IF TAKING SIMVASTATIN OR LOVASTATIN?

A
  • AZOLES
  • MACROLIDES (CLARITHROMYCIN, ERYTHROMYCIN)
  • CYCLOSPORINE
  • GRAPE FRUIT
27
Q

WHAT’S THE MX AX OF EZETIMIBE?

A

INHIBIT ABSORPTION CHOLESTEROL IN THE SMALL INTESNTINE

28
Q

PCSK9 INH?

A

ALIROCUMAB ( PRALUENT)

EVOLOCURAMAB ( REPATHA)

29
Q

WHAT’S MX AX PCSK9 INH?

A

THEY BIND TO PCSK9 SO THIS DOESN’T DEGRATES LDL RECEPTORS, THERE ARE MORE LDL RECEPTORS AVAILABLE TO CLEAR LDL LOWERING LDL AROUND 60%

30
Q

WHICH ARE THE BILE ACID SEQUESTRANS AND WHICH ONE IS APPROVE FOR GLYCEMIC CONTROL?

A
  • CHOLESTYRAMINE (PREVALITE)
  • COLESEVELAM (WELCHOL)&raquo_space;> APPROVED GLYCECMIC CONTROL
  • COLESTIPOL (COLESTID)
31
Q

FIBRATES?

A
  • FENOFIBRATE

- GEMFIBROZIL

Naplex (6 decks)

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