Patho - diseases of salivary glands Flashcards
Sialadenitis is ……….
Inflammation of salivary glands
Causes of Sialadenitis
- ductal obstruction
- infection
- autoimmune disease
Common infectious disease in parotid glands
Mumps (epidemic parotitis)
Causative organism of mumps
paramyxo virus
Clinical Picture of mumps
Unilateral or bilateral enlargement of the parotid
Microscopic picture of mumps
Infiltration of lymphocytes and histocytes ( MQ)
Complications of mumps
- in children: self-limited
- In adult: orchitis, oopheritis, pancreatitis
Bacterial sialadenitis Is most common in
submandibular glands
Causative organism of Bacterial sialadenitis is
staphylococci and streptococci
Predisposing factors of Bacterial sialadenitis
Obstruction of the duct by stones
Sialolithiasis (Salivary calculi) Most common in ………
the submandibular duct
The stone In Sialolithiasis is formed of ……………..
formed of a nidus of :
- desquamated ductal epithelium
- Inspissated secretion
- calcium phosphate
Clinical picture of Sialolithiasis
Pain, enlargement of the gland at meal time due to accumulation of
secretion
Sjogren syndrome is an
It is an autoimmune disease
Pathogenesis of Sjogren syndrome
destruction of lacrimal and salivary glands
Clinical picture of Sjogren syndrome
- Dry eye keratoconjunctivitis
sicca - Dry mouth xerostomia
Etiology of Sjogren syndrome
2ry form associated with rheumatoid arthritis
Serology in Sjogren syndrome shows
Anti Ro / SSA antibody
Anti La / SSB antibody
Complications of Sjogren syndrom
B-cell lymphoma ( non - Hodgkin lymphoma)
Microscopic picture of Sjogren syndrome
- Atrophy of acini
- Loss of architecture
- Lymphoplasmacytic infiltrate ———-> lymphoid follicles
Benign tumors of Salivary Glands
- Papillary cystadenoma lymphomatosum [Warthin›s tumor]
- Pleomorphic adenoma [mixed salivary tumor]
Gross of Papillary cystadenoma lymphomatosum [Warthin›s tumor]
large cystic areas
Microscopic picture of Papillary cystadenoma lymphomatosum [Warthin›s tumor]
covered by columnar oncocytes
The most common tumor of salivary glands
Pleomorphic adenoma [mixed salivary tumor] ( benign)
Pleomorphic adenoma [mixed salivary tumor] Affect which salivary gland ?
Parotid
Predisposing factors of Pleomorphic adenoma [mixed salivary tumor]
Male > female
Gross of Pleomorphic adenoma [mixed salivary tumor]
Encapsulated, firm, multinodular
Why Pleomorphic adenoma [mixed salivary tumor] recurrent ?
Due to failure to recognize extension of tumor beyond
Microscopic picture of Pleomorphic adenoma [mixed salivary tumor]
- Epithelial tissue :
1) Solid sheets or strands of epithelial cells .
2) Spindle-shaped myoepithelial cells .
- Mesenchymal tissue :
3) Myxomatous CT .
4) Cartilage or pseudo cartilage .
Malignant tumors of Salivary Glands
1) Carcinoma in pleomorphic adenoma
2) Adenoid cystic carcinoma (Teratoma)
3) Mucoepidermal carcinoma
In Carcinoma in pleomorphic adenoma Malignant change…………..with time
Increase
Carcinoma in pleomorphic adenoma Takes the form of
adenocarcinoma or undifferentiated carcinoma
Adenoid cystic carcinoma (Teratoma) found in
submandibular and minor salivary gland
Microscopic picture of Adenoid cystic carcinoma (Teratoma)
- Perineural invasion is common
- Swiss - cheese apperance
Commonest primary malignant tumour of salivary glands is
Mucoepidermal carcinoma
Mucoepidermal carcinoma affect
parotid
Microscopic picture of Mucoepidermal carcinoma
consists of mucous & cysts
