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Git > Patho - diseases of salivary glands > Flashcards

Patho - diseases of salivary glands Flashcards

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1
Q

Sialadenitis is ……….

A

Inflammation of salivary glands

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2
Q

Causes of Sialadenitis

A
  • ductal obstruction
  • infection
  • autoimmune disease
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3
Q

Common infectious disease in parotid glands

A

Mumps (epidemic parotitis)

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4
Q

Causative organism of mumps

A

paramyxo virus

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5
Q

Clinical Picture of mumps

A

Unilateral or bilateral enlargement of the parotid

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6
Q

Microscopic picture of mumps

A

Infiltration of lymphocytes and histocytes ( MQ)

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7
Q

Complications of mumps

A
  • in children: self-limited
  • In adult: orchitis, oopheritis, pancreatitis
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8
Q

Bacterial sialadenitis Is most common in

A

submandibular glands

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9
Q

Causative organism of Bacterial sialadenitis is

A

staphylococci and streptococci

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10
Q

Predisposing factors of Bacterial sialadenitis

A

Obstruction of the duct by stones

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11
Q

Sialolithiasis (Salivary calculi) Most common in ………

A

the submandibular duct

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12
Q

The stone In Sialolithiasis is formed of ……………..

A

formed of a nidus of :

  • desquamated ductal epithelium
  • Inspissated secretion
  • calcium phosphate
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13
Q

Clinical picture of Sialolithiasis

A

Pain, enlargement of the gland at meal time due to accumulation of

secretion

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14
Q

Sjogren syndrome is an

A

It is an autoimmune disease

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15
Q

Pathogenesis of Sjogren syndrome

A

destruction of lacrimal and salivary glands

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16
Q

Clinical picture of Sjogren syndrome

A
  • Dry eye keratoconjunctivitis
    sicca
  • Dry mouth xerostomia
17
Q

Etiology of Sjogren syndrome

A

2ry form associated with rheumatoid arthritis

18
Q

Serology in Sjogren syndrome shows

A

Anti Ro / SSA antibody

Anti La / SSB antibody

19
Q

Complications of Sjogren syndrom

A

B-cell lymphoma ( non - Hodgkin lymphoma)

20
Q

Microscopic picture of Sjogren syndrome

A
  • Atrophy of acini
  • Loss of architecture
  • Lymphoplasmacytic infiltrate ———-> lymphoid follicles
21
Q

Benign tumors of Salivary Glands

A
  1. Papillary cystadenoma lymphomatosum [Warthin›s tumor]
  2. Pleomorphic adenoma [mixed salivary tumor]
22
Q

Gross of Papillary cystadenoma lymphomatosum [Warthin›s tumor]

A

large cystic areas

23
Q

Microscopic picture of Papillary cystadenoma lymphomatosum [Warthin›s tumor]

A

covered by columnar oncocytes

24
Q

The most common tumor of salivary glands

A

Pleomorphic adenoma [mixed salivary tumor] ( benign)

25
Q

Pleomorphic adenoma [mixed salivary tumor] Affect which salivary gland ?

A

Parotid

26
Q

Predisposing factors of Pleomorphic adenoma [mixed salivary tumor]

A

Male > female

27
Q

Gross of Pleomorphic adenoma [mixed salivary tumor]

A

Encapsulated, firm, multinodular

28
Q

Why Pleomorphic adenoma [mixed salivary tumor] recurrent ?

A

Due to failure to recognize extension of tumor beyond

29
Q

Microscopic picture of Pleomorphic adenoma [mixed salivary tumor]

A
  • Epithelial tissue :

1) Solid sheets or strands of epithelial cells .

2) Spindle-shaped myoepithelial cells .

  • Mesenchymal tissue :

3) Myxomatous CT .

4) Cartilage or pseudo cartilage .

30
Q

Malignant tumors of Salivary Glands

A

1) Carcinoma in pleomorphic adenoma

2) Adenoid cystic carcinoma (Teratoma)

3) Mucoepidermal carcinoma

31
Q

In Carcinoma in pleomorphic adenoma Malignant change…………..with time

A

Increase

32
Q

Carcinoma in pleomorphic adenoma Takes the form of

A

adenocarcinoma or undifferentiated carcinoma

33
Q

Adenoid cystic carcinoma (Teratoma) found in

A

submandibular and minor salivary gland

34
Q

Microscopic picture of Adenoid cystic carcinoma (Teratoma)

A
  • Perineural invasion is common
  • Swiss - cheese apperance
35
Q

Commonest primary malignant tumour of salivary glands is

A

Mucoepidermal carcinoma

36
Q

Mucoepidermal carcinoma affect

A

parotid

37
Q

Microscopic picture of Mucoepidermal carcinoma

A

consists of mucous & cysts

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