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CVM > Path slide set 2 > Flashcards

Path slide set 2 Flashcards

1
Q

Treatment for kawasaki

A

Usually self limited but give IVIG and aspirin

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2
Q

A vascular proliferation in response to gram negative Bartonella bacilli that occurs on skin of immunocompromised patients

A

Bacillary angiomatosis

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3
Q

Histology of PAN

A
  • Transmural necrotizing inflammation containing neutrophils, eosinophils, lymphocytes, and macrophages
  • Fibrinoid necrosis (partial)
  • Sites of inflammation NOT circumferential
  • NO giant cells or granulomas
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4
Q

Bacillary angiomatosis is visualized how?

A

with PCR or with a Warthin-Starry stain

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5
Q

morphology for kaposi sarcoma

A

spindle cells

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6
Q

where is the gender preference for angiosarcoma?

A

males=females

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7
Q

Vasculitis in which 1/3 of patients have chronic hepatitis and HBsAg-HBsAb complexes are found in involved vessels

A

PAN

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8
Q

What is the origin of a glomus tumor

A

Smooth muscle cells

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9
Q

What are the most common vessels affected by microscopic polyangiitis

A

Renal glomeruli and lung capillaries

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10
Q

Malignant endothelial tumor in older individual that may occur anywhere but is common in skin, soft tissue, breast, and liver

A

angiosarcoma

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11
Q

Associated with Asthma and allergic Rhinitis

A

Chung-Strauss Syndrome

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12
Q

How can you differentiate primary from secondary Raynaud phenomenon?

A

Primary is symmetric and benign course

Secondary is asymmetric and worsens over time

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13
Q

What type of tumor is kaposi sarcoma?

A

an intermediate vascular tumor

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14
Q

Factor V leiden increases risk of what?

A

thrombophlebitis

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15
Q

A large lymphangioma of neck or axilla of children

A

Cavernous lymphangioma (cystic hygroma)

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16
Q

Most cases associated with MPO-ANCA

A

Microscopic polyangiitis

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17
Q

What is an effective treatment of Bacillary angiomatosis

A

Macrolide antibiotics

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18
Q

Whats the classic picture of Esophageal varices?

A

old alcoholic guy with cirrhosis

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19
Q

irregular, dilated vascular channels making a lesion with an indistinct border

A

Cavernous hemangioma

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20
Q

typical epidemiology for Primary Raynaud phenomenon

A

young women

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21
Q

What Kaposi is localized to skin, usually the distal lower extremities

A

Classic

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22
Q

Small vessel necrotizing vasculitis that may resemble PAN of M. Polyangiitis but also has eosinophils and granulomas

A

Chung-Strauss Syndrome

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23
Q

Histology of microscopic polyangiitis

A
  • segmental necrotizing inflammation with fibrinoid necrosis
  • many apoptotic neutrophils usually seen
  • “luekocytoclastic vasculitis
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24
Q

Thrombophlebitis almost always involves what?

A

deep veins in leg - can be completely asymptomatic

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25
Q

Age group classically involved in Polyarteritis nodosa (PAN)

A

Young adults

26
Q

has neoplastic endothelial cells that are plump and cuboidal resembling epithelium. Vascular channels may be difficult to recognize

A

Epithelioid hemangioendothelioma (an intermediate vascular tumor)

27
Q

Describe the presentation of Thromboangiitis obliterans (Berger disease)

A
  • May lead to vascular insufficiency of extremeties
  • Patients are almost always smokers and young adults
  • Inflammation may extend to involve adjacent veins and nerves leading to pain
  • Chronic ulcerations which may lead to gangrene
28
Q

What exogenous and endogenous agents may cause myocardial vessel vasospasm or “cardiac Raynaud” and may lead to ischemia or infarct?

A

Endo: epinephrine

Exog: cocaine

29
Q
  • localized forming red papules

- microscopically a proliferation of capillaries with plump endothelial cells

A

Bacillary angiomatosis

30
Q

Necrotizing vasculitis involving arterioles, capillaries and venues

A

Microscopic polyangiitis

31
Q

Besides the Aortic arch and it’s branches, what other vessels may be involved in Takayasu?

A

Pulmonary, Coronary, Renal

32
Q

what is the molecular marker for angiosarcoma?

A

CD31

33
Q

What is a cavernous lymphangioma (cystic hygroma) associated with?

A

Turner Syndrome

34
Q

Mucocutaneous lymph node syndrome

A

Kawasaki

35
Q

Vessels involved in Polyarteritis nodosa in decreasing frequency

A
  • Renal
  • heart
  • liver
  • GI
36
Q

3 types of hemangiomas

A
  • capillary
  • cavernous
  • pyogenic granuloma (lobular capillary hemangioma)
37
Q
  • Aphthous ulcers of oral cavity
  • Genital ulcers
  • uveitis
A

Behcet disease

38
Q

Thin-walled capillaries, well defined and tightly packed together

A

capillary hemangioma

39
Q

What therapy is usually effective in PAN?

A

Immunosuppressive

40
Q

Associated with HLA-B51

A

Behcet Disease

41
Q

A type of capillary hemangioma that is RAPIDLY growing often in oral mucosa where they may ulcerate and often due to trauma to site and healing process

A

pyogenic granuloma (lobular capillary hemangioma)

42
Q

Age group for Takayasu Arteritis

A

Younger than 50

43
Q

95% associated with PR3-ANCA

A

Granulomatosis with polyangiitis (Wegener)

44
Q

A systemic vasculitis that spares pulmonary vessels

A

Polyarteritis nodosa

45
Q

epidemiology for Granulomatosis with polyangiitis (Wegener granulomatosis)?

A

usually middle age males. ave age of 40

46
Q

Common benign tumor showing a localized increase in neoplastic blood vessels commonly on skin and mucous membranes of head and neck and in liver.

If congenital (juvenile or “strawberry) they often regress

A

hemangiomas

47
Q

epidemiology for classic kaposi

A

older men from middle eastern, mediterranean or eastern european descent

48
Q

Age group for giant cell (temporal) Arteritis

A

> 50

49
Q

4 types of kaposi sarcoma

A
  • AIDS-associate
  • Classic
  • Endemic African
  • Transplant associated
50
Q

What treatment is usually successsful with Wegeners?

A

immunosuppressive

51
Q

Benign tumors arising from glomus bodies and most often appear in distal fingers and PAINFUL

A

Glomus tumor

52
Q

Vasculitis typically in small children involving coronary arteries and presenting as erythema of conjunctiva, oral mucosa, palms and soles, rash and cervical lymph node involvement

A

Kawasaki

53
Q

sinonasal and pharyngeal inflammation with granulomas and vasculitis and multiply necrotizing granulomas of the lower respiratory tract which may coalesce and cavitate

A

Granulomatosis with polyangiitis (Wegener granulomatosis)

54
Q

Acute and chronic THROMBOSING vasculitis of small and medium vessels, especially Tibial and Radial

A

Thromboangiitis obliterans (berger disease)

55
Q

Raynaud phenomenon can be secondary to what arterial diseases?

A
  • SLE
  • SCLERODERMA
  • thromboangiitis obliterans
56
Q

Migratory thrombophlebitis is particularly seen with what cancer?

A

mucin-producing adenocarcinomas lung, ovary, and pancreas

-you will probably already know the person has cancer

57
Q

Vasculitis involving aortic arch and major branch vessels giving diminished pulses of upper extremity

A

Takayasu arteritis (pulseless disease)

58
Q

What are cavernous hemangiomas more likely to do than capillary ones?

A

involve deep tissue and more likely to bleed

59
Q

What appear very similar to capillary hemangiomas but without RBCs and are on head/neck and axillae

A

Simple lymphangioma

60
Q

Histology for Giant cell (temporal) arteritis

A
  • Medial Granulomatous inflammation often with multinucleated giant cells
  • Fragmentation of Elastic lamina
  • Sites may be patchy and focal
  • Healed sites show scarring of media and intimal thickening
61
Q

Which two Kaposi’s can spread to lymph nodes and viscera?

A

AIDS and Transplant

CVM (6 decks)

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